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Healthcare systems around the world are grappling with issues like inefficient diagnostics, rising costs, and limited access to specialists. These problems often lead to delays in treatment and poor health outcomes. Most current AI and deep…

Artificial Intelligence · Computer Science 2025-12-22 Maliha Tabassum , M Shamim Kaiser

Healthcare and medicine are multimodal disciplines that deal with multimodal data for reasoning and diagnosing multiple diseases. Although some multimodal reasoning models have emerged for reasoning complex tasks in scientific domains,…

Artificial Intelligence · Computer Science 2025-09-16 Susanta Mitra

The clinical adoption of artificial intelligence (AI) in medical diagnostics is critically hampered by its black-box nature, which prevents clinicians from verifying the rationale behind automated decisions. To overcome this fundamental…

While multimodal large language models offer a promising solution to the "black box" nature of health AI by generating interpretable reasoning traces, verifying the validity of these traces remains a critical challenge. Existing evaluation…

With the rapid growth of large language models (LLMs) and vision-language models (VLMs) in medicine, simply integrating clinical text and medical imaging does not guarantee reliable reasoning. Existing multimodal models often produce…

Artificial Intelligence · Computer Science 2025-12-29 Zelin Zang , Wenyi Gu , Siqi Ma , Dan Yang , Yue Shen , Zhu Zhang , Guohui Fan , Wing-Kuen Ling , Fuji Yang

Recent advances in deep learning have completely transformed the domain of computational pathology (CPath). More specifically, it has altered the diagnostic workflow of pathologists by integrating foundation models (FMs) and vision-language…

Machine Learning · Computer Science 2024-09-19 Dibaloke Chanda , Milan Aryal , Nasim Yahya Soltani , Masoud Ganji

Large language models (LLMs) have demonstrated notable potential in medical applications, yet they face substantial challenges in handling complex real-world clinical diagnoses using conventional prompting methods. Current prompt…

Artificial Intelligence · Computer Science 2026-03-02 Wenliang Li , Rui Yan , Xu Zhang , Li Chen , Hongji Zhu , Jing Zhao , Junjun Li , Mengru Li , Wei Cao , Zihang Jiang , Wei Wei , Kun Zhang , Shaohua Kevin Zhou

Adaptive multimodal reasoning has emerged as a promising frontier in Vision-Language Models (VLMs), aiming to dynamically modulate between tool-augmented visual reasoning and text reasoning to enhance both effectiveness and efficiency.…

Computer Vision and Pattern Recognition · Computer Science 2026-04-09 Xintong Zhang , Xiaowen Zhang , Jingrong Wu , Zhi Gao , Shilin Yan , Zhenxin Diao , Kunpeng Gao , Xuanyan Chen , Yuwei Wu , Yunde Jia , Qing Li

Despite the impressive capabilities of Large Language Models (LLMs), existing Conversational Health Agents (CHAs) remain static and brittle, incapable of adaptive multi-turn reasoning, symptom clarification, or transparent decision-making.…

Computation and Language · Computer Science 2025-07-11 Xinyi Liu , Dachun Sun , Yi R. Fung , Dilek Hakkani-Tür , Tarek Abdelzaher

This paper presents an innovative large language model (LLM) agent framework for enhancing diagnostic accuracy in simulated clinical environments using the AgentClinic benchmark. The proposed automatic correction enables doctor agents to…

Artificial Intelligence · Computer Science 2024-10-15 Abhishek Dutta , Yen-Che Hsiao

The emergence of tool-calling-based agent systems introduces a more evidence-driven paradigm for pathology image analysis in contrast to the coarse-grained text-image diagnostic approaches. With the recent large-scale experimental adoption…

Artificial Intelligence · Computer Science 2026-02-24 Haoyang Su , Shaoting Zhang , Xiaosong Wang

In diagnostic reports, experts encode complex imaging data into clinically actionable information. They describe subtle pathological findings that are meaningful in their anatomical context. Reports follow relatively consistent structures,…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Felicia Bader , Philipp Seeböck , Anastasia Bartashova , Ulrike Attenberger , Georg Langs

Recent advances in Omni models have enabled unified multimodal perception and generation. However, most existing systems still exhibit rigid reasoning behaviors, either overthinking simple problems or failing to reason when necessary. To…

Artificial Intelligence · Computer Science 2025-12-05 Dongchao Yang , Songxiang Liu , Disong Wang , Yuanyuan Wang , Guanglu Wan , Helen Meng

Deep learning methods, in particular convolutional neural networks, have emerged as a powerful tool in medical image computing tasks. While these complex models provide excellent performance, their black-box nature may hinder real-world…

Image and Video Processing · Electrical Eng. & Systems 2022-10-18 Yuzhe Lu , Adam Perer

Medical Anomaly Detection (MedAD) presents a significant opportunity to enhance diagnostic accuracy using Large Multimodal Models (LMMs) to interpret and answer questions based on medical images. However, the reliance on Supervised…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Haitao Zhang , Yingying Wang , Jiaxiang Wang , Haote Xu , Hongyang Zhang , Yirong Chen , Yue Huang , Xinghao Ding

Computational pathology foundation models (CPathFMs) have emerged as a powerful approach for analyzing histopathological data, leveraging self-supervised learning to extract robust feature representations from unlabeled whole-slide images.…

Computer Vision and Pattern Recognition · Computer Science 2025-02-27 Dong Li , Guihong Wan , Xintao Wu , Xinyu Wu , Ajit J. Nirmal , Christine G. Lian , Peter K. Sorger , Yevgeniy R. Semenov , Chen Zhao

Computational pathology demands both visual pattern recognition and dynamic integration of structured domain knowledge, including taxonomy, grading criteria, and clinical evidence. In practice, diagnostic reasoning requires linking…

Artificial Intelligence · Computer Science 2026-05-26 Jinyue Li , Yuci Liang , Qiankun Li , Xinheng Lyu , Jiayu Qian , Huabao Chen , Kun Wang , Zhigang Zeng , Anil Anthony Bharath , Yang Liu

Developing 3D vision-language models with robust clinical reasoning remains a challenge due to the inherent complexity of volumetric medical imaging, the tendency of models to overfit superficial report patterns, and the lack of…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Haoran Lai , Zihang Jiang , Kun Zhang , Qingsong Yao , Rongsheng Wang , Zhiyang He , Xiaodong Tao , Wei Wei , Shaohua Kevin Zhou

The rapid proliferation of large language models (LLMs) in healthcare creates an urgent need for scalable and psychometrically sound evaluation methods. Conventional static benchmarks are costly to administer repeatedly, vulnerable to data…

Computation and Language · Computer Science 2026-03-26 Tianpeng Zheng , Zhehan Jiang , Jiayi Liu , Shicong Feng

Artificial intelligence-driven adaptive learning systems are reshaping education through data-driven adaptation of learning experiences. Yet many of these systems lack transparency, offering limited insight into how decisions are made. Most…

Artificial Intelligence · Computer Science 2025-08-04 Maryam Mosleh , Marie Devlin , Ellis Solaiman