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Deep neural networks have shown promising results for various clinical prediction tasks such as diagnosis, mortality prediction, predicting duration of stay in hospital, etc. However, training deep networks -- such as those based on…

Machine Learning · Computer Science 2018-07-06 Priyanka Gupta , Pankaj Malhotra , Lovekesh Vig , Gautam Shroff

Electronic health records (EHRs) contain structured and unstructured data of significant clinical and research value. Various machine learning approaches have been developed to employ information in EHRs for risk prediction. The majority of…

The effectiveness of artificial intelligence (AI) in healthcare is significantly hindered by unstructured clinical documentation, which results in noisy, inconsistent, and logically fragmented training data. To address this challenge, we…

Machine Learning · Computer Science 2025-10-21 Dun Liu , Qin Pang , Guangai Liu , Hongyu Mou , Jipeng Fan , Yiming Miao , Pin-Han Ho , Limei Peng

Clinical robustness is critical to the safe deployment of medical Large Language Models (LLMs), but key questions remain about how LLMs and humans may differ in response to the real-world variability typified by clinical settings. To…

Artificial Intelligence · Computer Science 2025-06-23 Abinitha Gourabathina , Yuexing Hao , Walter Gerych , Marzyeh Ghassemi

This article introduces the concept of the algorithmic unconscious to designate the set of structural determinations that operate within large language models (LLMs) without being accessible either to the model's own reflexivity or to that…

Computers and Society · Computer Science 2026-02-24 Philippe Boisnard

This position paper examines how large language models (LLMs) can support thematic analysis of unstructured clinical transcripts, a widely used but resource-intensive method for uncovering patterns in patient and provider narratives. We…

Computation and Language · Computer Science 2025-09-30 Seungjun Yi , Joakim Nguyen , Terence Lim , Andrew Well , Joseph Skrovan , Mehak Beri , YongGeon Lee , Kavita Radhakrishnan , Liu Leqi , Mia Markey , Ying Ding

This paper contributes with a pragmatic evaluation framework for explainable Machine Learning (ML) models for clinical decision support. The study revealed a more nuanced role for ML explanation models, when these are pragmatically embedded…

Artificial Intelligence · Computer Science 2022-12-22 Oskar Wysocki , Jessica Katharine Davies , Markel Vigo , Anne Caroline Armstrong , Dónal Landers , Rebecca Lee , André Freitas

Electronic Health Records (EHRs) have been heavily used to predict various downstream clinical tasks such as readmission or mortality. One of the modalities in EHRs, clinical notes, has not been fully explored for these tasks due to its…

Computation and Language · Computer Science 2019-06-05 Bonggun Shin , Julien Hogan , Andrew B. Adams , Raymond J. Lynch , Rachel E. Patzer , Jinho D. Choi

Healthcare providers usually record detailed notes of the clinical care delivered to each patient for clinical, research, and billing purposes. Due to the unstructured nature of these narratives, providers employ dedicated staff to assign…

Computation and Language · Computer Science 2022-08-03 Chufan Gao , Mononito Goswami , Jieshi Chen , Artur Dubrawski

Large Language Models (LLMs) are increasingly demonstrating the potential to reach human-level performance in generating clinical summaries from patient-clinician conversations. However, these summaries often focus on patients' biology…

The application of large language models (LLMs) in clinical decision support faces significant challenges of "tunnel vision" and diagnostic hallucinations present in their processing unstructured electronic health records (EHRs). To address…

Artificial Intelligence · Computer Science 2026-04-28 Zhiqi Lv , Duofan Tu , Jun Li , Mingyue Zhao , Heqin Zhu , Wenliang Li , Shaohua Kevin Zhou

Modern generative pre-trained language models excel at open-ended text generation, yet continue to underperform on structure-related tasks such as NER, relation extraction, and semantic role labeling, especially when compared to…

Computation and Language · Computer Science 2025-12-23 Minho Lee , Junghyun Min , Yerang Kim , Woochul Lee , Yeonsoo Lee

Clinical dialogue represents a complex duality requiring both the empathetic fluency of natural conversation and the rigorous precision of evidence-based medicine. While Large Language Models possess unprecedented linguistic capabilities,…

Other Quantitative Biology · Quantitative Biology 2025-12-02 Xiaoquan Zhi , Hongke Zhao , Likang Wu , Chuang Zhao , Hengshu Zhu

Data mining and machine learning hold great potential to enable health systems to systematically use data and analytics to identify inefficiencies and best practices that improve care and reduce costs. Waveform data offers particularly…

Machine Learning · Computer Science 2025-03-17 Michael Albada

Large language models (LLMs) and agentic systems have shown promise for clinical decision support, but existing works largely assume that evidence has already been curated and handed to the model. Real-world clinical workflows instead…

Computation and Language · Computer Science 2026-05-20 Juncheng Wu , Letian Zhang , Yuhan Wang , Haoqin Tu , Hardy Chen , Zijun Wang , Cihang Xie , Yuyin Zhou

This paper presents a novel approach named \textbf{C}ontextually \textbf{R}elevant \textbf{I}mputation leveraging pre-trained \textbf{L}anguage \textbf{M}odels (\textbf{CRILM}) for handling missing data in tabular datasets. Instead of…

Computation and Language · Computer Science 2025-03-28 Ahatsham Hayat , Mohammad Rashedul Hasan

Accurate and explainable health event predictions are becoming crucial for healthcare providers to develop care plans for patients. The availability of electronic health records (EHR) has enabled machine learning advances in providing these…

Machine Learning · Computer Science 2021-05-18 Chang Lu , Chandan K. Reddy , Prithwish Chakraborty , Samantha Kleinberg , Yue Ning

Accurate short-term mortality prediction in heart failure (HF) remains challenging, particularly when relying on structured electronic health record (EHR) data alone. We evaluate transformer-based models on a French HF cohort, comparing…

Computation and Language · Computer Science 2026-04-03 Oumaima El Khettari , Virgile Barthet , Guillaume Hocquet , Joconde Weller , Emmanuel Morin , Pierre Zweigenbaum

Large Language Models (LLMs) are increasingly being explored for clinical question answering and decision support, yet safe deployment critically requires reliable handling of patient measurements in heterogeneous clinical notes. Existing…

Computation and Language · Computer Science 2026-04-16 Minh-Vuong Nguyen , Fatemeh Shiri , Zhuang Li , Karin Verspoor

The effective utilization of structured data, integral to corporate data strategies, has been challenged by the rise of large language models (LLMs) capable of processing unstructured information. This shift prompts the question: can LLMs…

Computation and Language · Computer Science 2024-10-22 Zhouhong Gu , Haoning Ye , Xingzhou Chen , Zeyang Zhou , Hongwei Feng , Yanghua Xiao
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