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Explainability features are intended to provide insight into the internal mechanisms of an AI device, but there is a lack of evaluation techniques for assessing the quality of provided explanations. We propose a framework to assess and…

Artificial Intelligence · Computer Science 2025-06-18 Miguel A. Lago , Ghada Zamzmi , Brandon Eich , Jana G. Delfino

Artificial intelligence (AI) systems utilizing deep neural networks (DNNs) and machine learning (ML) algorithms are widely used for solving important problems in bioinformatics, biomedical informatics, and precision medicine. However,…

Quantitative Methods · Quantitative Biology 2023-02-24 Md. Rezaul Karim , Tanhim Islam , Oya Beyan , Christoph Lange , Michael Cochez , Dietrich Rebholz-Schuhmann , Stefan Decker

Industrial Cyber-Physical Systems (CPS) are sensitive infrastructure from both safety and economics perspectives, making their reliability critically important. Machine Learning (ML), specifically deep learning, is increasingly integrated…

Machine Learning · Computer Science 2026-04-09 Annemarie Jutte , Uraz Odyurt

Understanding AI systems' inner workings is critical for ensuring value alignment and safety. This review explores mechanistic interpretability: reverse engineering the computational mechanisms and representations learned by neural networks…

Artificial Intelligence · Computer Science 2024-08-27 Leonard Bereska , Efstratios Gavves

The application of Artificial Intelligence (AI) and Machine Learning (ML) to cybersecurity challenges has gained traction in industry and academia, partially as a result of widespread malware attacks on critical systems such as cloud…

Cryptography and Security · Computer Science 2022-07-14 Subash Neupane , Jesse Ables , William Anderson , Sudip Mittal , Shahram Rahimi , Ioana Banicescu , Maria Seale

The integration of artificial intelligence into business processes has significantly enhanced decision-making capabilities across various industries such as finance, healthcare, and retail. However, explaining the decisions made by these AI…

Artificial Intelligence · Computer Science 2024-10-29 Arne Grobrugge , Nidhi Mishra , Johannes Jakubik , Gerhard Satzger

European Law now requires AI to be explainable in the context of adverse decisions affecting European Union (EU) citizens. At the same time, it is expected that there will be increasing instances of AI failure as it operates on imperfect…

Artificial Intelligence · Computer Science 2019-08-28 J. L. Olds , M. S. Khan , M. Nayebpour , N. Koizumi

Machine learning systems deployed in medical devices require governance frameworks that ensure safety while enabling continuous improvement. Regulatory bodies including the FDA and European Union have introduced mechanisms such as the…

Machine Learning · Computer Science 2026-03-25 Fardin Afdideh , Mehdi Astaraki , Fernando Seoane , Farhad Abtahi

Artificial Intelligence (AI) systems are now an integral part of multiple industries. In clinical research, AI supports automated adverse event detection in clinical trials, patient eligibility screening for protocol enrollment, and data…

Artificial Intelligence · Computer Science 2025-12-10 Laxmiraju Kandikatla , Branislav Radeljic

Decision-making algorithms are being used in important decisions, such as who should be enrolled in health care programs and be hired. Even though these systems are currently deployed in high-stakes scenarios, many of them cannot explain…

Computers and Society · Computer Science 2022-05-12 Gabriel Lima , Nina Grgić-Hlača , Jin Keun Jeong , Meeyoung Cha

Fairness of machine learning models in healthcare has drawn increasing attention from clinicians, researchers, and even at the highest level of government. On the other hand, the importance of developing and deploying interpretable or…

Machine Learning · Computer Science 2024-09-04 Mary M. Lucas , Xiaoyang Wang , Chia-Hsuan Chang , Christopher C. Yang , Jacqueline E. Braughton , Quyen M. Ngo

Deep learning has enabled ECG diagnostic models with strong performance in tasks such as arrhythmia classification and abnormality detection. However, accuracy alone is insufficient for clinical deployment because it does not explain why a…

Machine Learning · Computer Science 2026-05-20 Jong-Hwan Jang , Yong-yeon Jo

Artificial intelligence-augmented technology represents a considerable opportunity for improving healthcare delivery. Significant progress has been made to demonstrate the value of complex models to enhance clinicians` efficiency in…

Human-Computer Interaction · Computer Science 2025-04-08 Mohammad Golam Kibria , Lauren Kucirka , Javed Mostafa

With the rise of complex cyber devices Cyber Forensics (CF) is facing many new challenges. For example, there are dozens of systems running on smartphones, each with more than millions of downloadable applications. Sifting through this…

Cryptography and Security · Computer Science 2026-02-02 Shahid Alam , Zeynep Altiparmak

Explainability is one of the key ethical concepts in the design of AI systems. However, attempts to operationalize this concept thus far have tended to focus on approaches such as new software for model interpretability or guidelines with…

Computers and Society · Computer Science 2020-10-06 Ben Zevenbergen , Allison Woodruff , Patrick Gage Kelley

Artificial Intelligence (AI) is rapidly expanding and integrating more into daily life to automate tasks, guide decision making, and enhance efficiency. However, complex AI models, which make decisions without providing clear explanations…

Software Engineering · Computer Science 2025-09-03 Lakshit Arora , Sanjay Surendranath Girija , Shashank Kapoor , Aman Raj , Dipen Pradhan , Ankit Shetgaonkar

Ensuring responsible use of artificial intelligence (AI) has become imperative as autonomous systems increasingly influence critical societal domains. However, the concept of trustworthy AI remains broad and multi-faceted. This thesis…

Artificial Intelligence · Computer Science 2025-10-28 Filip Cano

Fairness is one of the most commonly identified ethical principles in existing AI guidelines, and the development of fair AI-enabled systems is required by new and emerging AI regulation. But most approaches to addressing the fairness of…

The increasing availability of large collections of electronic health record (EHR) data and unprecedented technical advances in deep learning (DL) have sparked a surge of research interest in developing DL based clinical decision support…

Machine Learning · Computer Science 2021-12-07 Di Jin , Elena Sergeeva , Wei-Hung Weng , Geeticka Chauhan , Peter Szolovits

Explainable artificial intelligence and interpretable machine learning are research domains growing in importance. Yet, the underlying concepts remain somewhat elusive and lack generally agreed definitions. While recent inspiration from…

Artificial Intelligence · Computer Science 2022-09-12 Kacper Sokol , Peter Flach