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Machine learning interatomic potentials (MLIPs) trained on large, chemically diverse datasets are revolutionizing computational chemistry, enabling molecular dynamics simulations of battery electrolytes with near-DFT accuracy over 10,000…

Despite the increasing prevalence of large language models (LLMs), we still have a limited understanding of how their representational spaces are structured. This limits our ability to interpret how and what they learn or relate them to…

Efficiently creating a concise but comprehensive data set for training machine-learned interatomic potentials (MLIPs) is an under-explored problem. Active learning, which uses biased or unbiased molecular dynamics (MD) to generate candidate…

The core of molecular dynamics simulation fundamentally lies in the interatomic potential. Traditional empirical potentials lack accuracy, while first-principles methods are computationally prohibitive. Machine learning interatomic…

Machine Learning · Computer Science 2026-03-25 Shuyu Bi , Zhede Zhao , Qiangchao Sun , Tao Hu , Xionggang Lu , Hongwei Cheng

We present a physically motivated strategy for the construction of training sets for transferable machine learning interatomic potentials. It is based on a systematic exploration of all possible space groups in random crystal structures,…

Materials Science · Physics 2023-03-29 Marvin Poul , Liam Huber , Erik Bitzek , Jörg Neugebauer

This paper addresses the challenges of storage and communication costs for large-scale datasets in resource-constrained edge devices by proposing a novel dataset quantization approach to reduce intra-sample redundancy. Unlike traditional…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Chenyue Yu , Jianyu Yu

Machine learning interatomic potentials (MLIPs) are promising surrogates for quantum mechanics evaluations in ab-initio molecular dynamics simulations due to their ability to reproduce the energy and force landscape within chemical accuracy…

Materials Science · Physics 2023-08-31 Emil Annevelink , Venkatasubramanian Viswanathan

Previous work showed empirically that large neural networks can be significantly reduced in size while preserving their accuracy. Model compression became a central research topic, as it is crucial for deployment of neural networks on…

Machine Learning · Computer Science 2020-01-06 Ben Mussay , Margarita Osadchy , Vladimir Braverman , Samson Zhou , Dan Feldman

Machine-learned interatomic potentials (MILPs) are rapidly gaining interest for molecular modeling, as they provide a balance between quantum-mechanical level descriptions of atomic interactions and reasonable computational efficiency.…

Computational Physics · Physics 2024-08-30 Gustavo R. Pérez-Lemus , Yinan Xu , Yezhi Jin , Pablo F. Zubieta Rico , Juan J. de Pablo

In the field of Machine Learning Interatomic Potentials (MLIPs), understanding the intricate relationship between data biases, specifically conformational and structural diversity, and model generalization is critical in improving the…

Chemical Physics · Physics 2023-11-03 Nikhil Shenoy , Prudencio Tossou , Emmanuel Noutahi , Hadrien Mary , Dominique Beaini , Jiarui Ding

Machine learning interatomic potentials (MLIPs) have achieved remarkable accuracy on standard benchmarks, yet their ability to reproduce molecular kinetics -- critical for reaction rate calculations -- remains largely unexplored. We…

We present an information-theoretic framework for understanding overfitting and underfitting in machine learning and prove the formal undecidability of determining whether an arbitrary classification algorithm will overfit a dataset.…

Machine Learning · Computer Science 2020-11-10 Daniel Bashir , George D. Montanez , Sonia Sehra , Pedro Sandoval Segura , Julius Lauw

In general, large datasets enable deep learning models to perform with good accuracy and generalizability. However, massive high-fidelity simulation datasets (from molecular chemistry, astrophysics, computational fluid dynamics (CFD), etc.…

Machine Learning · Computer Science 2022-07-27 Wai Tong Chung , Ki Sung Jung , Jacqueline H. Chen , Matthias Ihme

Machine learning potentials (MLPs) for atomistic simulations have an enormous prospective impact on materials modeling, offering orders of magnitude speedup over density functional theory (DFT) calculations without appreciably sacrificing…

Materials Science · Physics 2022-01-20 Dylan Bayerl , Christopher M. Andolina , Shyam Dwaraknath , Wissam A. Saidi

For many use cases, combining information from different datasets can be of interest to improve a machine learning model's performance, especially when the number of samples from at least one of the datasets is small. However, a potential…

Machine Learning · Statistics 2023-05-17 Thu Nguyen , Rabindra Khadka , Nhan Phan , Anis Yazidi , Pål Halvorsen , Michael A. Riegler

State-of-the-art trainable machine translation evaluation metrics like xCOMET achieve high correlation with human judgment but rely on large encoders (up to 10.7B parameters), making them computationally expensive and inaccessible to…

Computation and Language · Computer Science 2024-11-11 Daniil Larionov , Mikhail Seleznyov , Vasiliy Viskov , Alexander Panchenko , Steffen Eger

Though offering unprecedented pathways to molecular dynamics (MD) simulations of technologically-relevant materials and conditions, machine-learning interatomic potentials (MLIPs) are typically trained for ``simple'' materials and…

Materials Science · Physics 2025-07-09 Nikola Koutná , Shuyao Lin , Lars Hultman , Davide G. Sangiovanni , Paul H. Mayrhofer

A linear regression-based machine learned interatomic potential (MLIP) was developed for the silicon-carbon system. The MLIP was predominantly trained on structures discovered through a genetic algorithm, encompassing the entire…

Mesoscale and Nanoscale Physics · Physics 2024-03-26 Michael MacIsaac , Salil Bavdekar , Douglas Spearot , Ghatu Subhash

In-context learning has established itself as an important learning paradigm for Large Language Models (LLMs). In this paper, we demonstrate that LLMs can learn encoding keys in-context and perform analysis directly on encoded…

Computation and Language · Computer Science 2026-04-16 Andresa Rodrigues de Campos , David Lee , Imry Kissos , Piyush Paritosh

Machine learning interatomic potentials (MLIPs) enable more efficient molecular dynamics (MD) simulations with ab initio accuracy, which have been used in various domains of physical science. However, distribution shift between training and…

Computational Physics · Physics 2024-05-15 Taoyong Cui , Chenyu Tang , Dongzhan Zhou , Yuqiang Li , Xingao Gong , Wanli Ouyang , Mao Su , Shufei Zhang