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Cell type identification from single-cell transcriptomic data is a common goal of single-cell RNA sequencing (scRNAseq) data analysis. Neural networks have been employed to identify cell types from scRNAseq data with high performance.…

Genomics · Quantitative Biology 2020-05-11 Xishuang Dong , Shanta Chowdhury , Uboho Victor , Xiangfang Li , Lijun Qian

Accurate cell type annotation is a crucial step in analyzing single-cell RNA sequencing (scRNA-seq) data, which provides valuable insights into cellular heterogeneity. However, due to the high dimensionality and prevalence of zero elements…

Machine Learning · Computer Science 2025-08-14 Huifa Li , Jie Fu , Xinlin Zhuang , Haolin Yang , Xinpeng Ling , Tong Cheng , Haochen xue , Imran Razzak , Zhili Chen

Single-cell RNA-seq (scRNA-seq) technology is a powerful tool for unraveling the complexity of biological systems. One of essential and fundamental tasks in scRNA-seq data analysis is Cell Type Annotation (CTA). In spite of tremendous…

Genomics · Quantitative Biology 2024-11-04 Chaochen Wu , Meiyun Zuo , Lei Xie

Contemporary domain adaptive semantic segmentation aims to address data annotation challenges by assuming that target domains are completely unannotated. However, annotating a few target samples is usually very manageable and worthwhile…

Computer Vision and Pattern Recognition · Computer Science 2021-06-08 Jiaxing Huang , Dayan Guan , Aoran Xiao , Shijian Lu

Domain adaptation (DA) paves the way for label annotation and dataset bias issues by the knowledge transfer from a label-rich source domain to a related but unlabeled target domain. A mainstream of DA methods is to align the feature…

Computer Vision and Pattern Recognition · Computer Science 2021-08-13 Shuang Li , Mixue Xie , Fangrui Lv , Chi Harold Liu , Jian Liang , Chen Qin , Wei Li

Convolutional neural networks (CNNs) have led to significant improvements in the semantic segmentation of images. When source and target datasets come from different modalities, CNN performance suffers due to domain shift. In such cases…

Computer Vision and Pattern Recognition · Computer Science 2022-10-10 Serban Stan , Mohammad Rostami

Convolutional Neural Networks (CNNs) have achieved state-of-the-art performance for medical image segmentation, yet need plenty of manual annotations for training. Semi-Supervised Learning (SSL) methods are promising to reduce the…

Computer Vision and Pattern Recognition · Computer Science 2022-08-19 Ran Gu , Jingyang Zhang , Guotai Wang , Wenhui Lei , Tao Song , Xiaofan Zhang , Kang Li , Shaoting Zhang

Existing deep learning-based change detection methods try to elaborately design complicated neural networks with powerful feature representations, but ignore the universal domain shift induced by time-varying land cover changes, including…

Computer Vision and Pattern Recognition · Computer Science 2022-08-09 Jia Liu , Wenjie Xuan , Yuhang Gan , Juhua Liu , Bo Du

Weakly supervised segmentation methods have gained significant attention due to their ability to reduce the reliance on costly pixel-level annotations during model training. However, the current weakly supervised nuclei segmentation…

Image and Video Processing · Electrical Eng. & Systems 2025-02-04 Ye Zhang , Yifeng Wang , Zijie Fang , Hao Bian , Linghan Cai , Ziyue Wang , Yongbing Zhang

Deep learning approaches for semantic segmentation rely primarily on supervised learning approaches and require substantial efforts in producing pixel-level annotations. Further, such approaches may perform poorly when applied to unseen…

Computer Vision and Pattern Recognition · Computer Science 2021-10-22 Ying Chen , Xu Ouyang , Kaiyue Zhu , Gady Agam

Single-cell RNA-seq (scRNA-seq) enables atlas-scale profiling of complex tissues, revealing rare lineages and transient states. Yet, assigning biologically valid cell identities remains a bottleneck because markers are tissue- and…

Semi-supervised domain adaptation (SSDA) aims to bridge source and target domain distributions, with a small number of target labels available, achieving better classification performance than unsupervised domain adaptation (UDA). However,…

Computer Vision and Pattern Recognition · Computer Science 2024-01-23 Jichang Li , Guanbin Li , Yizhou Yu

Accurate phenotype prediction from RNA sequencing (RNA-seq) data is essential for diagnosis, biomarker discovery, and personalized medicine. Deep learning models have demonstrated strong potential to outperform classical machine learning…

Machine Learning · Computer Science 2026-03-10 Kevin Dradjat , Massinissa Hamidi , Blaise Hanczar

Semantic segmentation requires a lot of training data, which necessitates costly annotation. There have been many studies on unsupervised domain adaptation (UDA) from one domain to another, e.g., from computer graphics to real images.…

Computer Vision and Pattern Recognition · Computer Science 2022-10-07 Zhijie Wang , Xing Liu , Masanori Suganuma , Takayuki Okatani

The segmentation of coronary arteries by convolutional neural network is promising yet requires a large amount of labor-intensive manual annotations. Transferring knowledge from retinal vessels in widely-available public labeled fundus…

Image and Video Processing · Electrical Eng. & Systems 2021-05-07 Jingyang Zhang , Ran Gu , Guotai Wang , Hongzhi Xie , Lixu Gu

Accurate segmentation of organelle instances, e.g., mitochondria, is essential for electron microscopy analysis. Despite the outstanding performance of fully supervised methods, they highly rely on sufficient per-pixel annotated data and…

Computer Vision and Pattern Recognition · Computer Science 2022-11-01 Dafei Qiu , Jiajin Yi , Jialin Peng

Single-cell RNA sequencing (scRNA-seq) technology enables systematic delineation of cellular states and interactions, providing crucial insights into cellular heterogeneity. Building on this potential, numerous computational methods have…

Genomics · Quantitative Biology 2025-11-11 Ping Xu , Zaitian Wang , Zhirui Wang , Pengjiang Li , Ran Zhang , Gaoyang Li , Hanyu Xie , Jiajia Wang , Yuanchun Zhou , Pengfei Wang

Cellular nuclei recognition serves as a fundamental and essential step in the workflow of digital pathology. However, with disparate source organs and staining procedures among histology image clusters, the scanned tiles inherently conform…

Quantitative Methods · Quantitative Biology 2024-07-22 Jianan Fan , Dongnan Liu , Canran Li , Hang Chang , Heng Huang , Filip Braet , Mei Chen , Weidong Cai

Single-cell RNA sequencing (scRNA-seq) has revolutionized our ability to analyze gene expression at the resolution of individual cells, providing unprecedented insights into cellular heterogeneity and complex biological systems. This paper…

Other Quantitative Biology · Quantitative Biology 2024-06-11 Megha Patel , Nimish Magre , Himanshi Motwani , Nik Bear Brown

Background: Single-cell RNA sequencing (scRNA-seq) yields valuable insights about gene expression and gives critical information about complex tissue cellular composition. In the analysis of single-cell RNA sequencing, the annotations of…

Genomics · Quantitative Biology 2023-03-29 Xiaowen Cao , Li Xing , Elham Majd , Hua He , Junhua Gu , Xuekui Zhang
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