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Large language models (LLMs) have emerged as powerful tools in chemistry, significantly impacting molecule design, property prediction, and synthesis optimization. This review highlights LLM capabilities in these domains and their potential…

Machine Learning · Computer Science 2024-11-18 Mayk Caldas Ramos , Christopher J. Collison , Andrew D. White

This paper reports on the implementation and evaluation of a Model Context Protocol (MCP) server for DraCor, enabling Large Language Models (LLM) to autonomously interact with the DraCor API. We conducted experiments focusing on tool…

Software Engineering · Computer Science 2025-08-20 Peer Trilcke , Ingo Börner , Henny Sluyter-Gäthje , Daniil Skorinkin , Frank Fischer , Carsten Milling

The rapid rise of Large Language Models (LLMs)-based intelligent agents underscores the need for robust, scalable evaluation frameworks. Existing methods rely on static benchmarks and labor-intensive data collection, limiting practical…

Artificial Intelligence · Computer Science 2025-08-05 Zhiwei Liu , Jielin Qiu , Shiyu Wang , Jianguo Zhang , Zuxin Liu , Roshan Ram , Haolin Chen , Weiran Yao , Shelby Heinecke , Silvio Savarese , Huan Wang , Caiming Xiong

Since the introduction of the Model Context Protocol (MCP), the number of available tools for Large Language Models (LLMs) has increased significantly. These task-specific tool sets offer an alternative to general-purpose tools such as web…

Computation and Language · Computer Science 2025-12-12 Reza Esfandiarpoor , Vishwas Suryanarayanan , Stephen H. Bach , Vishal Chowdhary , Anthony Aue

In computational biophysics, where molecular data is expanding rapidly and system complexity is increasing exponentially, large language models (LLMs) and agent-based systems are fundamentally reshaping the field. This perspective article…

Significant advancements have occurred in the application of Large Language Models (LLMs) for social simulations. Despite this, their abilities to perform teaming in task-oriented social events are underexplored. Such capabilities are…

Artificial Intelligence · Computer Science 2025-08-18 Yuan Li , Lichao Sun , Yixuan Zhang

The growing complexity of power systems has made accurate load forecasting more important than ever. An increasing number of advanced load forecasting methods have been developed. However, the static design of current methods offers no…

Machine Learning · Computer Science 2025-05-23 Yu Zuo , Dalin Qin , Yi Wang

Recent developments in large language models (LLMs) have unlocked new opportunities for healthcare, from information synthesis to clinical decision support. These new LLMs are not just capable of modeling language, but can also act as…

Human-Computer Interaction · Computer Science 2023-09-21 Nikita Mehandru , Brenda Y. Miao , Eduardo Rodriguez Almaraz , Madhumita Sushil , Atul J. Butte , Ahmed Alaa

Managing scan protocols in Computed Tomography (CT), which includes adjusting acquisition parameters or configuring reconstructions, as well as selecting postprocessing tools in a patient-specific manner, is time-consuming and requires…

Artificial Intelligence · Computer Science 2025-09-25 Xingjian Kang , Linda Vorberg , Andreas Maier , Alexander Katzmann , Oliver Taubmann

This paper presents the development and evaluation of a Large Language Model (LLM), also known as foundation models, based multi-agent system framework for complex event processing (CEP) with a focus on video query processing use cases. The…

Multiagent Systems · Computer Science 2025-01-06 Talha Zeeshan , Abhishek Kumar , Susanna Pirttikangas , Sasu Tarkoma

In recent years, data science agents powered by Large Language Models (LLMs), known as "data agents," have shown significant potential to transform the traditional data analysis paradigm. This survey provides an overview of the evolution,…

Artificial Intelligence · Computer Science 2025-12-01 Maojun Sun , Ruijian Han , Binyan Jiang , Houduo Qi , Defeng Sun , Yancheng Yuan , Jian Huang

Agentic AI systems built around large language models (LLMs) are moving away from closed, single-model frameworks and toward open ecosystems that connect a variety of agents, external tools, and resources. The Model Context Protocol (MCP)…

Cryptography and Security · Computer Science 2026-02-03 Xinyi Hou , Shenao Wang , Yifan Zhang , Ziluo Xue , Yanjie Zhao , Cai Fu , Haoyu Wang

Explicit modeling of capabilities and skills -- whether based on ontologies, Asset Administration Shells, or other technologies -- requires considerable manual effort and often results in representations that are not easily accessible to…

Software Engineering · Computer Science 2025-12-10 Luis Miguel Vieira da Silva , Aljosha Köcher , Felix Gehlhoff

Large Language Model (LLM) Agents are an emerging computing paradigm that blends generative machine learning with tools such as code interpreters, web browsing, email, and more generally, external resources. These agent-based systems…

Cryptography and Security · Computer Science 2024-10-23 Xiaohan Fu , Shuheng Li , Zihan Wang , Yihao Liu , Rajesh K. Gupta , Taylor Berg-Kirkpatrick , Earlence Fernandes

The control of complex laboratory instrumentation often requires significant programming expertise, creating a barrier for researchers lacking computational skills. This work explores the potential of large language models (LLMs), such as…

Artificial Intelligence · Computer Science 2026-04-07 Yong Xie , Kexin He , Andres Castellanos-Gomez

The recent advance in Large Language Models (LLMs) has shaped a new paradigm of AI agents, i.e., LLM-based agents. Compared to standalone LLMs, LLM-based agents substantially extend the versatility and expertise of LLMs by enhancing LLMs…

Software Engineering · Computer Science 2025-12-04 Junwei Liu , Kaixin Wang , Yixuan Chen , Xin Peng , Zhenpeng Chen , Lingming Zhang , Yiling Lou

The emergence of Large Language Model (LLM) agents enables us to build agent-based intelligent systems that move beyond the role of a "tool" to become genuine collaborators with humans, thereby realizing a novel human-agent collaboration…

Human-Computer Interaction · Computer Science 2026-02-06 Bingsheng Yao , Chaoran Chen , April Yi Wang , Sherry Tongshuang Wu , Toby Jia-jun Li , Dakuo Wang

Large Language Models (LLMs) have revolutionized Natural Language Processing but exhibit limitations, particularly in autonomously addressing novel challenges such as reasoning and problem-solving. Traditional techniques like…

Multiagent Systems · Computer Science 2024-01-03 Sumedh Rasal

Large Language Model (LLM) agents significantly extend the capabilities of standalone LLMs, empowering them to interact with external tools (e.g., APIs, functions) and complete various tasks in a self-directed fashion. The challenge of tool…

Artificial Intelligence · Computer Science 2024-02-19 Weizhou Shen , Chenliang Li , Hongzhan Chen , Ming Yan , Xiaojun Quan , Hehong Chen , Ji Zhang , Fei Huang

Tool use has turned large language models (LLMs) into powerful agents that can perform complex multi-step tasks by dynamically utilising external software components. However, these tools must be implemented in advance by human developers,…

Computation and Language · Computer Science 2025-06-02 Georg Wölflein , Dyke Ferber , Daniel Truhn , Ognjen Arandjelović , Jakob Nikolas Kather