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Over the past decades, the increasing dimensionality of data has increased the need for effective data decomposition methods. Existing approaches, however, often rely on linear models or lack sufficient interpretability or flexibility. To…

Methodology · Statistics 2026-03-24 Jiaji Su , Zhigang Yao

Molecular dynamics simulations produce huge datasets of temporal sequences of molecules. It is of interest to summarize the shape evolution of the molecules in a succinct, low-dimensional representation. However, Euclidean techniques such…

Methodology · Statistics 2019-03-25 Ian L. Dryden , Kwang-Rae Kim , Charles A. Laughton , Huiling Le

In many applications, the data lie on a type of cone, where there is a distinction between an overall scale variable and the remaining scale-free structure. For example, the joint size and shape of objects are points on a cone, where size…

Methodology · Statistics 2026-04-23 Yanyan Zhan , Ian L. Dryden , Yuexuan Wu

In an era where big and high-dimensional data is readily available, data scientists are inevitably faced with the challenge of reducing this data for expensive downstream computation or analysis. To this end, we present here a new method…

Methodology · Statistics 2018-06-05 Simon Mak , V. Roshan Joseph

Feature selection is a critical task in machine learning and statistics. However, existing feature selection methods either (i) rely on parametric methods such as linear or generalized linear models, (ii) lack theoretical false discovery…

Machine Learning · Statistics 2025-07-18 Omar Melikechi , David B. Dunson , Jeffrey W. Miller

RNA structure determination is essential for understanding its biological functions. However, the reconstruction process often faces challenges, such as atomic clashes, which can lead to inaccurate models. To address these challenges, we…

Biomolecules · Quantitative Biology 2026-03-04 Menghao Wu , Zhigang Yao

High-dimensional, low sample-size (HDLSS) data problems have been a topic of immense importance for the last couple of decades. There is a vast literature that proposed a wide variety of approaches to deal with this situation, among which…

Methodology · Statistics 2021-07-09 Kaixu Yang , Tapabrata Maiti

Principal component analysis continues to be a powerful tool in dimension reduction of high dimensional data. We assume a variance-diverging model and use the high-dimension, low-sample-size asymptotics to show that even though the…

Statistics Theory · Mathematics 2020-09-28 Sungkyu Jung

Feature or variable selection is a problem inherent to large data sets. While many methods have been proposed to deal with this problem, some can scale poorly with the number of predictors in a data set. Screening methods scale linearly…

Methodology · Statistics 2023-01-09 Naveed Merchant , Jeffrey D. Hart

Physics-informed neural networks (PINNs) have been demonstrated to be efficient in solving partial differential equations (PDEs) from a variety of experimental perspectives. Some recent studies have also proposed PINN algorithms for PDEs on…

Numerical Analysis · Mathematics 2024-08-06 Guanhang Lei , Zhen Lei , Lei Shi , Chenyu Zeng , Ding-Xuan Zhou

Probabilistic Manifold Decomposition (PMD)\cite{doi:10.1137/25M1738863}, developed in our earlier work, provides a nonlinear model reduction by embedding high-dimensional dynamics onto low-dimensional probabilistic manifolds. The PMD has…

Numerical Analysis · Mathematics 2026-01-13 Jiaming Guo , Dunhui Xiao

Biological data including gene expression data are generally high-dimensional and require efficient, generalizable, and scalable machine-learning methods to discover their complex nonlinear patterns. The recent advances in machine learning…

Machine Learning · Computer Science 2020-12-21 Dinesh Singh , Héctor Climente-González , Mathis Petrovich , Eiryo Kawakami , Makoto Yamada

Deep neural networks (DNNs) have been widely applied to solve real-world regression problems. However, selecting optimal network structures remains a significant challenge. This study addresses this issue by linking neuron selection in DNNs…

Computation · Statistics 2025-09-30 Noah Yi-Ting Hung , Li-Hsiang Lin , Vince D. Calhoun

Nested sampling (NS) computes parameter posterior distributions and makes Bayesian model comparison computationally feasible. Its strengths are the unsupervised navigation of complex, potentially multi-modal posteriors until a well-defined…

Computation · Statistics 2023-07-11 Johannes Buchner

This paper presents a novel non-linear model reduction method: Probabilistic Manifold Decomposition (PMD), which provides a powerful framework for constructing non-intrusive reduced-order models (ROMs) by embedding a high-dimensional system…

Numerical Analysis · Mathematics 2026-01-09 Jiaming Guo , Dunhui Xiao

Foundation models and their checkpoints have significantly advanced deep learning, boosting performance across various applications. However, fine-tuned models often struggle outside their specific domains and exhibit considerable…

The applications of traditional statistical feature selection methods to high-dimension, low sample-size data often struggle and encounter challenging problems, such as overfitting, curse of dimensionality, computational infeasibility, and…

Machine Learning · Statistics 2023-12-19 Kexuan Li , Fangfang Wang , Lingli Yang , Ruiqi Liu

In statistical dimensionality reduction, it is common to rely on the assumption that high dimensional data tend to concentrate near a lower dimensional manifold. There is a rich literature on approximating the unknown manifold, and on…

Machine Learning · Statistics 2022-02-22 Didong Li , Minerva Mukhopadhyay , David B. Dunson

Principal component analysis (PCA) is very popular to perform dimension reduction. The selection of the number of significant components is essential but often based on some practical heuristics depending on the application. Only few works…

Machine Learning · Statistics 2017-09-19 Clément Elvira , Pierre Chainais , Nicolas Dobigeon

We present a novel view of nonlinear manifold learning using derivative-free optimization techniques. Specifically, we propose an extension of the classical multi-dimensional scaling (MDS) method, where instead of performing gradient…

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