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Related papers: MADD: Multi-Agent Drug Discovery Orchestra

200 papers

The advancement of artificial intelligence algorithms has expanded their application to several fields such as the biomedical domain. Artificial intelligence systems, including Large Language Models (LLMs), can be particularly advantageous…

As LLMs grow in capability, the task of supervising LLMs becomes more challenging. Supervision failures can occur if LLMs are sensitive to factors that supervisors are unaware of. We investigate Mechanistic Anomaly Detection (MAD) as a…

Machine Learning · Computer Science 2025-04-15 David O. Johnston , Arkajyoti Chakraborty , Nora Belrose

Drug discovery is a complex, multi-step pipeline that remains heavily dependent on manual, experience-driven operations; meanwhile, existing customized artificial intelligence tools are fragmented across web applications, desktop software,…

Biomolecules · Quantitative Biology 2026-03-03 Qihua Pan , Dong Xu , Qianwei Yang , Jenna Xinyi Yao , Sisi Yuan , Zexuan Zhu , Jianqiang Li , Junkai Ji

LLM agents have incredible potential for scientific discovery applications. However, the performance of LLM agents on real-world, small molecule drug design (SMDD) tasks across diverse chemistries and targets is unclear. Current evaluation…

Artificial Intelligence · Computer Science 2026-05-26 Kevin Han , Renfei Zhang , Kathy Wei , Hamed Mahdavi , Niloofar Mireshghallah , Amir Barati Farimani

Large-language models (LLMs) and agentic systems present exciting opportunities to accelerate drug discovery. In this study, we examine the modularity of LLM-based agentic systems for drug discovery, i.e., whether parts of the system such…

Machine Learning · Computer Science 2025-08-22 Laura van Weesep , Samuel Genheden , Ola Engkvist , Jens Sjölund

The growing dependence on mobile phones and their apps has made multi-user interactive features, like chat calls, live streaming, and video conferencing, indispensable for bridging the gaps in social connectivity caused by physical and…

Software Engineering · Computer Science 2025-09-17 Sidong Feng , Changhao Du , Huaxiao Liu , Qingnan Wang , Zhengwei Lv , Mengfei Wang , Chunyang Chen

Large Language Models (LLMs) have advanced autonomous agents' planning and decision-making, yet they struggle with complex tasks requiring diverse expertise and multi-step reasoning. Multi-Agent Debate (MAD) systems, introduced in NLP…

Software Engineering · Computer Science 2025-03-18 Jina Chun , Qihong Chen , Jiawei Li , Iftekhar Ahmed

Automatic search for Multi-Agent Systems has recently emerged as a key focus in agentic AI research. Several prior approaches have relied on LLM-based free-form search over the code space. In this work, we propose a more structured…

Architecture design is a critical step in software development. However, creating a high-quality architecture is often costly due to the significant need for human expertise and manual effort. Recently, agents built upon Large Language…

Software Engineering · Computer Science 2025-03-27 Yiran Zhang , Ruiyin Li , Peng Liang , Weisong Sun , Yang Liu

Large Language Model (LLM)-empowered multi-agent systems extend the cognitive boundaries of individual agents through disciplined collaboration and interaction, while constructing these systems often requires labor-intensive manual designs.…

Machine Learning · Computer Science 2025-06-10 Guibin Zhang , Luyang Niu , Junfeng Fang , Kun Wang , Lei Bai , Xiang Wang

Today's scientific challenges, from climate modeling to Inertial Confinement Fusion design to novel material design, require exploring huge design spaces. In order to enable high-impact scientific discovery, we need to scale up our ability…

To fully expedite AI-powered chemical research, high-quality chemical databases are the foundation. Automatic extraction of chemical information from the literature is essential for constructing reaction databases, but it is currently…

Artificial Intelligence · Computer Science 2026-03-09 Yufan Chen , Ching Ting Leung , Bowen Yu , Jianwei Sun , Yong Huang , Linyan Li , Hao Chen , Hanyu Gao

Large language models (LLMs) integrated with autonomous agents hold significant potential for advancing scientific discovery through automated reasoning and task execution. However, applying LLM agents to drug discovery is still constrained…

Artificial Intelligence · Computer Science 2025-07-29 Kun Li , Zhennan Wu , Shoupeng Wang , Jia Wu , Shirui Pan , Wenbin Hu

The integration of deep learning-based glaucoma detection with large language models (LLMs) presents an automated strategy to mitigate ophthalmologist shortages and improve clinical reporting efficiency. However, applying general LLMs to…

Multiagent Systems · Computer Science 2025-12-18 Philip R. Liu , Sparsh Bansal , Jimmy Dinh , Aditya Pawar , Ramani Satishkumar , Shail Desai , Neeraj Gupta , Xin Wang , Shu Hu

Self-driving labs are transforming drug discovery by enabling automated, AI-guided experimentation, but they face challenges in orchestrating complex workflows, integrating diverse instruments and AI models, and managing data efficiently.…

Software Engineering · Computer Science 2025-04-02 Yao Fehlis , Paul Mandel , Charles Crain , Betty Liu , David Fuller

Recent advancements in medical Large Language Models (LLMs) have showcased their powerful reasoning and diagnostic capabilities. Despite their success, current unified multimodal medical LLMs face limitations in knowledge update costs,…

Computation and Language · Computer Science 2025-06-25 Yucheng Zhou , Lingran Song , Jianbing Shen

Accurate detection of errors in large language models (LLM) responses is central to the success of scalable oversight, or providing effective supervision to superhuman intelligence. Yet, self-diagnosis is often unreliable on complex tasks…

Machine Learning · Computer Science 2025-10-27 Yongqiang Chen , Gang Niu , James Cheng , Bo Han , Masashi Sugiyama

Multi-agent debate (MAD) is an emerging approach to improving the reasoning capabilities of large language models (LLMs). Existing MAD methods rely on multiple rounds of interaction among agents to reach consensus, and the final output is…

Artificial Intelligence · Computer Science 2025-09-16 Yu Cui , Hang Fu , Haibin Zhang , Licheng Wang , Cong Zuo

Advances in large language models (LLMs) have recently opened new and promising avenues for small-molecule drug discovery. Yet existing LLM-based approaches for molecular generation often suffer from high rates of invalid and low-quality…

Machine Learning · Computer Science 2026-05-15 Andrew Y. Zhou , Sharvaree Vadgama , Sumanth Varambally , Peter Eckmann , Michael K. Gilson , Rose Yu

We propose MADS (Multi-Agent Dialogue Simulation), a scalable framework for generating persuasive multi-turn dialogues via agent self-play. MADS employs three coordinated agents: User Agents designed to simulate diverse persona-driven…

Computation and Language · Computer Science 2025-10-14 Mingjin Li , Yu Liu , Huayi Liu , Xiang Ye , Chao Jiang , Hongguang Zhang , Yu Ruan