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The standard paradigm for confirmatory clinical trials is to compare experimental treatments with a control, for example the standard of care or a placebo. However, it is not always the case that a suitable control exists. Efficient…

Methodology · Statistics 2024-10-29 Thomas Burnett , Thomas Jaki

Test-negative designs with added controls have recently been proposed to study COVID-19. An individual is test-positive or test-negative accordingly if they took a test for a disease but tested positive or tested negative. Adding a control…

Methodology · Statistics 2020-05-15 Bikram Karmakar , Dylan Small

Envelope model also known as multivariate regression model was proposed to solve the multiple response regression problems. It measures the linear association between predictors and multiple responses by using the minimal reducing subspace…

Methodology · Statistics 2018-05-07 Bochao Jia

Determining the precise rank is an important problem in many large-scale applications with matrix data exploiting low-rank plus noise models. In this paper, we suggest a universal approach to rank inference via residual subsampling (RIRS)…

Statistics Theory · Mathematics 2024-11-12 Xiao Han , Qing Yang , Yingying Fan

In this paper, we study the linear transformation model in the most general setup. This model includes many important and popular models in statistics and econometrics as special cases. Although it has been studied for many years, the…

Methodology · Statistics 2021-03-26 Tao Yu , Pengfei Li , Baojiang Chen , Ao Yuan , Jing Qin

Conventional multiple hypothesis tests use step-up, step-down, or closed testing methods to control the overall error rates. We will discuss marrying these methods with adaptive multistage sampling rules and stopping rules to perform…

Methodology · Statistics 2011-07-12 Jay Bartroff , Tze Leung Lai

Low-rank approximation of a matrix by means of random sampling has been consistently efficient in its empirical studies by many scientists who applied it with various sparse and structured multipliers, but adequate formal support for this…

Numerical Analysis · Mathematics 2016-06-07 Victor Y. Pan , Liang Zhao

We extend the scope of risk measures for which backtesting models are available by proposing a multinomial backtesting method for general distortion risk measures. The method relies on a stratification and randomization of risk levels. We…

Risk Management · Quantitative Finance 2024-08-02 Sören Bettels , Sojung Kim , Stefan Weber

We present a novel approach for constrained Bayesian inference. Unlike current methods, our approach does not require convexity of the constraint set. We reduce the constrained variational inference to a parametric optimization over the…

Machine Learning · Computer Science 2013-09-27 Oluwasanmi Koyejo , Joydeep Ghosh

In a standard regression problem, we have a set of explanatory variables whose effect on some response vector is modeled. For wide binary data, such as genetic marker data, we often have two limitations. First, we have more parameters than…

Methodology · Statistics 2021-09-20 Katharina Parry , Leo N. Geppert , Alexander Munteanu , Katja Ickstadt

In this paper we study multivariate ranks and quantiles, defined using the theory of optimal transport, and build on the work of Chernozhukov et al.(2017) and Hallin et al.(2021). We study the characterization, computation and properties of…

Statistics Theory · Mathematics 2021-05-06 Promit Ghosal , Bodhisattva Sen

This work proposes new inference methods for a regression coefficient of interest in a (heterogeneous) quantile regression model. We consider a high-dimensional model where the number of regressors potentially exceeds the sample size but a…

Statistics Theory · Mathematics 2017-10-05 Alexandre Belloni , Victor Chernozhukov , Kengo Kato

Regression is one of the most commonly used statistical techniques. However, testing regression systems is a great challenge because of the absence of test oracle in general. In this paper, we show that Metamorphic Testing is an effective…

Methodology · Statistics 2021-08-24 Quang-Hung Luu , Man F. Lau , Sebastian P. H. Ng , Tsong Yueh Chen

In many high-dimensional prediction or classification tasks, complementary data on the features are available, e.g. prior biological knowledge on (epi)genetic markers. Here we consider tasks with numerical prior information that provide an…

Methodology · Statistics 2022-12-19 Armin Rauschenberger , Zied Landoulsi , Mark A. van de Wiel , Enrico Glaab

Consider the multiple testing problem of testing null hypotheses $H_1,...,H_s$. A classical approach to dealing with the multiplicity problem is to restrict attention to procedures that control the familywise error rate ($\mathit{FWER}$),…

Statistics Theory · Mathematics 2007-06-13 Joseph P. Romano , Azeem M. Shaikh

External controls from historical trials or observational data can augment randomized controlled trials when large-scale randomization is impractical or unethical, such as in drug evaluation for rare diseases. However, non-randomized…

Methodology · Statistics 2025-05-08 Ke Zhu , Shu Yang , Xiaofei Wang

Response-adaptive randomization allows the probabilities of allocating patients to treatments in a clinical trial to change based on the previously observed response data, in order to achieve different experimental goals. One concern over…

Methodology · Statistics 2022-04-13 Ekkehard Glimm , David Robertson

This paper investigates the identification of quantiles and quantile regression parameters when observations are set valued. We define the identification set of quantiles of random sets in a way that extends the definition of quantiles for…

Methodology · Statistics 2020-04-10 Arie Beresteanu , Yuya Sasaki

Invariant causal prediction provides a useful framework for identifying causal predictors of a response using heterogeneous data from multiple environments. One valuable property of the original invariant causal prediction method is that it…

Methodology · Statistics 2026-05-21 Jinzhou Li , Jelle J Goeman

The capacity to address counterfactual "what if" inquiries is crucial for understanding and making use of causal influences. Traditional counterfactual inference, under Pearls' counterfactual framework, typically depends on having access to…

Machine Learning · Computer Science 2024-02-29 Shaoan Xie , Biwei Huang , Bin Gu , Tongliang Liu , Kun Zhang