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Artificial Intelligence Virtual Cells (AIVCs) aim to learn executable, decision-relevant models of cell state from multimodal, multiscale measurements. Recent studies have introduced single-cell and spatial foundation models, improved…

Artificial Intelligence · Computer Science 2025-12-03 Chengpeng Hu , Calvin Yu-Chian Chen

Large Language Models (LLMs) vary in their abilities on a range of tasks. Initiatives such as the Open LLM Leaderboard aim to quantify these differences with several large benchmarks (sets of test items to which an LLM can respond either…

Computation and Language · Computer Science 2025-02-21 Alex Kipnis , Konstantinos Voudouris , Luca M. Schulze Buschoff , Eric Schulz

We present REARANK, a large language model (LLM)-based listwise reasoning reranking agent. REARANK explicitly reasons before reranking, significantly improving both performance and interpretability. Leveraging reinforcement learning and…

Information Retrieval · Computer Science 2025-05-27 Le Zhang , Bo Wang , Xipeng Qiu , Siva Reddy , Aishwarya Agrawal

LLM-powered coding agents are reshaping the development paradigm. However, existing evaluation systems, neither traditional tests for humans nor benchmarks for LLMs, fail to capture this shift, excluding problems that require both human…

This work compares large language models (LLMs) and neuro-symbolic approaches in solving Raven's progressive matrices (RPM), a visual abstract reasoning test that involves the understanding of mathematical rules such as progression or…

Artificial Intelligence · Computer Science 2024-12-10 Michael Hersche , Giacomo Camposampiero , Roger Wattenhofer , Abu Sebastian , Abbas Rahimi

A method for studying the qualitative dynamical properties of abstract computing machines based on the approximation of their program-size complexity using a general lossless compression algorithm is presented. It is shown that the…

Computational Complexity · Computer Science 2011-01-24 Hector Zenil

Cellular image segmentation is essential for quantitative biology yet remains difficult due to heterogeneous modalities, morphological variability, and limited annotations. We present GenCellAgent, a training-free multi-agent framework that…

Quantitative Methods · Quantitative Biology 2026-05-12 Xi Yu , Yang Yang , Qun Liu , Yonghua Du , Sean McSweeney , Yuewei Lin

Large language models excel at interpreting complex natural language instructions, enabling them to perform a wide range of tasks. In the life sciences, single-cell RNA sequencing (scRNA-seq) data serves as the "language of cellular…

Computation and Language · Computer Science 2025-01-16 Yin Fang , Xinle Deng , Kangwei Liu , Ningyu Zhang , Jingyang Qian , Penghui Yang , Xiaohui Fan , Huajun Chen

A cell can be seen as an adaptive autonomous agent or as a society of adaptive autonomous agents, where each can exhibit a particular behaviour depending on its cognitive capabilities. We present an intracellular signalling model obtained…

Multiagent Systems · Computer Science 2007-05-23 Pedro Pablo Gonzalez Perez , Maura Cardenas Garcia , Carlos Gershenson , Jaime Lagunez-Otero

Recent advancements in reasoning-enhanced large language models (LLMs), such as DeepSeek-R1 and OpenAI-o3, have demonstrated significant progress. However, their application in professional medical contexts remains underexplored,…

Computation and Language · Computer Science 2025-03-11 Pengcheng Qiu , Chaoyi Wu , Shuyu Liu , Weike Zhao , Zhuoxia Chen , Hongfei Gu , Chuanjin Peng , Ya Zhang , Yanfeng Wang , Weidi Xie

We present $\textbf{Research Math Agents (RMA)}$, an agentic framework for automated reasoning on research-level mathematical problems. Unlike prior studies centered on competition mathematics or formal theorem proving, RMA targets…

Artificial Intelligence · Computer Science 2026-05-25 Zelin Zhao , Bo Yuan , Jaemoo Choi , Yongxin Chen

Agentic Reinforcement Learning (RL) enables Large Language Models (LLMs) to perform autonomous decision-making and long-term planning. Unlike standard LLM post-training, agentic RL workloads are highly heterogeneous, combining…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-12-30 Wei Gao , Yuheng Zhao , Tianyuan Wu , Shaopan Xiong , Weixun Wang , Dakai An , Lunxi Cao , Dilxat Muhtar , Zichen Liu , Haizhou Zhao , Ju Huang , Siran Yang , Yongbin Li , Wenbo Su , Jiamang Wang , Lin Qu , Bo Zheng , Wei Wang

Classical Cellular Automata (CCAs) are a powerful computational framework widely used to model complex systems driven by local interactions. Their simplicity lies in the use of a finite set of states and a uniform local rule, yet this…

Cellular Automata and Lattice Gases · Physics 2025-03-20 Enrico Formenti , Faizal Hafiz , Amelia Kunze , Davide La Torre

Large-scale biological discovery requires integrating massive, heterogeneous datasets like those from the JUMP Cell Painting consortium, but technical batch effects and a lack of generalizable models remain critical roadblocks. To address…

Computer Vision and Pattern Recognition · Computer Science 2025-09-10 Cedric Caruzzo , Jong Chul Ye

This paper introduces a simple formalism for dealing with deterministic, non- deterministic and stochastic cellular automata in an unified and composable manner. This formalism allows for local probabilistic correlations, a feature which is…

Discrete Mathematics · Computer Science 2013-05-20 Pablo Arrighi , Nicolas Schabanel , Guillaume Theyssier

The Abstraction and Reasoning Corpus (ARC) evaluates general reasoning capabilities that are difficult for both machine learning models and combinatorial search methods. We propose a neuro-symbolic approach that combines a transformer for…

Artificial Intelligence · Computer Science 2025-01-09 Paweł Batorski , Jannik Brinkmann , Paul Swoboda

Current Multimodal Large Language Models (MLLMs) excel in general visual reasoning but remain underexplored in Abstract Visual Reasoning (AVR), which demands higher-order reasoning to identify abstract rules beyond simple perception.…

Computer Vision and Pattern Recognition · Computer Science 2025-06-02 Yanbei Jiang , Yihao Ding , Chao Lei , Jiayang Ao , Jey Han Lau , Krista A. Ehinger

Root Cause Analysis (RCA) in mobile networks remains a challenging task due to the need for interpretability, domain expertise, and causal reasoning. In this work, we propose a lightweight framework that leverages Large Language Models…

Artificial Intelligence · Computer Science 2025-07-30 Mohamed Sana , Nicola Piovesan , Antonio De Domenico , Yibin Kang , Haozhe Zhang , Merouane Debbah , Fadhel Ayed

The ability of large language models (LLMs) to mimic human-like intelligence has led to a surge in LLM-based autonomous agents. Though recent LLMs seem capable of planning and reasoning given user instructions, their effectiveness in…

Large language models (LLMs) have recently gained significant attention as a promising approach to accelerate scientific discovery. However, their application in open-ended scientific domains such as biology remains limited, primarily due…

Machine Learning · Computer Science 2026-05-21 Yunhui Jang , Lu Zhu , Jake Fawkes , Alisandra Kaye Denton , Dominique Beaini , Emmanuel Noutahi