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Evaluating lesion progression and treatment response via longitudinal lesion tracking plays a critical role in clinical practice. Automated approaches for this task are motivated by prohibitive labor costs and time consumption when lesion…

Computer Vision and Pattern Recognition · Computer Science 2022-12-13 Wen Tang , Han Kang , Haoyue Zhang , Pengxin Yu , Corey W. Arnold , Rongguo Zhang

In view of the recent paradigm shift in deep AI based image processing methods, medical image processing has advanced considerably. In this study, we propose a novel deep neural network (DNN), entitled InceptNet, in the scope of medical…

Image and Video Processing · Electrical Eng. & Systems 2023-09-06 Amirhossein Sajedi , Mohammad Javad Fadaeieslam

This study proposes a Transformer-based longitudinal modeling method to address challenges in clinical risk classification with heterogeneous Electronic Health Record (EHR) data, including irregular temporal patterns, large modality…

Machine Learning · Computer Science 2025-11-07 Anzhuo Xie , Wei-Chen Chang

Randomized controlled trials (RCTs) are the accepted standard for treatment effect estimation but they can be infeasible due to ethical reasons and prohibitive costs. Single-arm trials, where all patients belong to the treatment group, can…

The call for patient-focused drug development is loud and clear, as expressed in the 21st Century Cures Act and in recent guidelines and initiatives of regulatory agencies. Among the factors contributing to modernized drug development and…

Interactive segmentation is a promising strategy for building robust, generalisable algorithms for volumetric medical image segmentation. However, inconsistent and clinically unrealistic evaluation hinders fair comparison and misrepresents…

Computer Vision and Pattern Recognition · Computer Science 2025-10-13 Parhom Esmaeili , Virginia Fernandez , Pedro Borges , Eli Gibson , Sebastien Ourselin , M. Jorge Cardoso

We consider a general difference-in-differences model in which the treatment variable of interest may be non-binary and its value may change in each period. It is generally difficult to estimate treatment parameters defined with the…

Econometrics · Economics 2023-05-30 Takahide Yanagi

Medical automatic diagnosis aims to imitate human doctors in real-world diagnostic processes and to achieve accurate diagnoses by interacting with the patients. The task is formulated as a sequential decision-making problem with a series of…

Machine Learning · Computer Science 2022-06-07 Hongyi Yuan , Sheng Yu

Causal Inference has wide applications in various areas such as E-commerce and precision medicine, and its performance heavily relies on the accurate estimation of the Individual Treatment Effect (ITE). Conventionally, ITE is predicted by…

Machine Learning · Computer Science 2023-10-23 Kailiang Zhong , Fengtong Xiao , Yan Ren , Yaorong Liang , Wenqing Yao , Xiaofeng Yang , Ling Cen

Motivation: The importance of clinical data in understanding the pathophysiology of complex disorders has prompted the launch of multiple initiatives designed to generate patient-level data from various modalities. While these studies can…

Personalized medicine seeks to identify the causal effect of treatment for a particular patient as opposed to a clinical population at large. Most investigators estimate such personalized treatment effects by regressing the outcome of a…

Machine Learning · Statistics 2021-09-02 Eric V. Strobl , Shyam Visweswaran

Recent methodological developments have introduced new black-box approaches to better estimate heterogeneous treatment effects; however, these methods fall short of providing interpretable characterizations of the underlying individuals who…

Methodology · Statistics 2025-08-19 Melody Huang , Tiffany M. Tang , Ana M. Kenney

Deep neural networks have demonstrated promising performance on image recognition tasks. However, they may heavily rely on confounding factors, using irrelevant artifacts or bias within the dataset as the cue to improve performance. When a…

Computer Vision and Pattern Recognition · Computer Science 2023-03-03 Siyuan Yan , Zhen Yu , Xuelin Zhang , Dwarikanath Mahapatra , Shekhar S. Chandra , Monika Janda , Peter Soyer , Zongyuan Ge

Disease-symptom datasets are significant and in demand for medical research, disease diagnosis, clinical decision-making, and AI-driven health management applications. These datasets help identify symptom patterns associated with specific…

Computation and Language · Computer Science 2025-09-09 Abdullah Al Shafi , Rowzatul Zannat , Abdul Muntakim , Mahmudul Hasan

Users of social platforms often perceive these sites as supportive spaces to post about their mental health issues. Those conversations contain important traces about individuals' health risks. Recently, researchers have exploited this…

Computation and Language · Computer Science 2024-08-21 Eliseo Bao , Anxo Pérez , Javier Parapar

This study introduces a data-driven, machine learning-based method to detect suitable control variables and instruments for assessing the causal effect of a treatment on an outcome in observational data. Our approach tests the joint…

Econometrics · Economics 2026-05-20 Nicolas Apfel , Julia Hatamyar , Martin Huber , Jannis Kueck

The explosive growth of textual data over time presents a significant challenge in uncovering evolving themes and trends. Existing dynamic topic modeling techniques, while powerful, often exist in fragmented pipelines that lack robust…

Computation and Language · Computer Science 2025-07-15 Suman Adhya , Debarshi Kumar Sanyal

Skin cancer is one of the most common types of cancer around the world. For this reason, over the past years, different approaches have been proposed to assist detect it. Nonetheless, most of them are based only on dermoscopy images and do…

Image and Video Processing · Electrical Eng. & Systems 2019-11-20 Andre G. C. Pacheco , Renato A. Krohling

Pain is a multifaceted phenomenon that affects a substantial portion of the population. Reliable and consistent evaluation supports individuals experiencing pain and enables the development of effective and advanced management strategies.…

Artificial Intelligence · Computer Science 2025-09-17 Stefanos Gkikas , Ioannis Kyprakis , Manolis Tsiknakis

Clinical trials assessing neurological treatment are challenging due to the diversity of brain function, and the difficulty in quantifying it. Traditional treatment studies in epilepsy use seizure frequency as the primary outcome measure,…

Applications · Statistics 2025-12-02 Ian Miller , Ann Hyslop , Colin Decker