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Multiple Instance Learning (MIL), a powerful strategy for weakly supervised learning, is able to perform various prediction tasks on gigapixel Whole Slide Images (WSIs). However, the tens of thousands of patches in WSIs usually incur a vast…

Computer Vision and Pattern Recognition · Computer Science 2023-03-14 Zhuchen Shao , Liuxi Dai , Yifeng Wang , Haoqian Wang , Yongbing Zhang

We study a multiclass multiple instance learning (MIL) problem where the labels only suggest whether any instance of a class exists or does not exist in a training sample or example. No further information, e.g., the number of instances of…

Machine Learning · Statistics 2019-03-15 Xi-Lin Li

Objective: Ulcerative colitis (UC), characterized by chronic inflammation with alternating remission-relapse cycles, requires precise histological healing (HH) evaluation to improve clinical outcomes. To overcome the limitations of…

Quantitative Methods · Quantitative Biology 2025-05-16 Zhengxuan Qiu , Bo Peng , Xiaoying Tang , Jiankun Wang , Qin Guo

Deep learning models have gained increasing adoption in medical image analysis. However, these models often produce overconfident predictions, which can compromise clinical accuracy and reliability. Bridging the gap between high-performance…

Image and Video Processing · Electrical Eng. & Systems 2026-03-24 Jutika Borah , Hidam Kumarjit Singh

Multiple Instance Learning (MIL) is a weak supervision learning paradigm that allows modeling of machine learning problems in which labels are available only for groups of examples called bags. A positive bag may contain one or more…

Machine Learning · Computer Science 2019-10-29 Amina Asif , Fayyaz ul Amir Afsar Minhas

Modern foundation models provide highly expressive visual representations, yet adapting them to high-resolution medical imaging remains challenging due to limited annotations and weak supervision. Mammography, in particular, is…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Nikola Jovišić , Milica Škipina , Nicola Dall'Asen , Dubravko Ćulibrk

Multiple instance learning (MIL) has enabled substantial progress in computational histopathology, where a large amount of patches from gigapixel whole slide images are aggregated into slide-level predictions. Heatmaps are widely used to…

Multiple instance learning (MIL) is a variation of traditional supervised learning problems where data (referred to as bags) are composed of sub-elements (referred to as instances) and only bag labels are available. MIL has a variety of…

Machine Learning · Computer Science 2018-05-02 Han Bao , Tomoya Sakai , Issei Sato , Masashi Sugiyama

In computational pathology, weak supervision has become the standard for deep learning due to the gigapixel scale of WSIs and the scarcity of pixel-level annotations, with Multiple Instance Learning (MIL) established as the principal…

Computer Vision and Pattern Recognition · Computer Science 2025-12-17 Andreas Lolos , Theofilos Christodoulou , Aris L. Moustakas , Stergios Christodoulidis , Maria Vakalopoulou

Various multi-instance learning (MIL) based approaches have been developed and successfully applied to whole-slide pathological images (WSI). Existing MIL methods emphasize the importance of feature aggregators, but largely neglect the…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Yicheng Song , Tiancheng Lin , Die Peng , Su Yang , Yi Xu

Multi-instance learning (MIL) deals with objects represented as bags of instances and can predict instance labels from bag-level supervision. However, significant performance gaps exist between instance-level MIL algorithms and supervised…

Machine Learning · Computer Science 2022-10-06 Weijia Zhang , Xuanhui Zhang , Han-Wen Deng , Min-Ling Zhang

To ensure safe clinical integration, deep learning models must provide more than just high accuracy; they require dependable uncertainty quantification. While current Medical Vision Transformers perform well, they frequently struggle with…

Image and Video Processing · Electrical Eng. & Systems 2026-04-13 Mohammed Maaz Sibhai , Abedalrhman Alkhateeb , Saad B. Ahmed

Deep learning classification models for medical image analysis often perform well on data from scanners that were used during training. However, when these models are applied to data from different vendors, their performance tends to drop…

Image and Video Processing · Electrical Eng. & Systems 2023-02-08 Coen de Vente , Bram van Ginneken , Carel B. Hoyng , Caroline C. W. Klaver , Clara I. Sánchez

Multiple Instance Learning (MIL) is widely used in medical imaging classification to reduce the labeling effort. While only bag labels are available for training, one typically seeks predictions at both bag and instance levels…

Computer Vision and Pattern Recognition · Computer Science 2024-11-19 Francisco M. Castro-Macías , Pablo Morales-Álvarez , Yunan Wu , Rafael Molina , Aggelos K. Katsaggelos

We present a fairness-aware framework for multi-class lung disease diagnosis from chest CT volumes, developed for the Fair Disease Diagnosis Challenge at the PHAROS-AIF-MIH Workshop (CVPR 2026). The challenge requires classifying CT scans…

Computer Vision and Pattern Recognition · Computer Science 2026-03-16 Aditya Parikh , Aasa Feragen

Treatment approaches for colorectal cancer (CRC) are highly dependent on the molecular subtype, as immunotherapy has shown efficacy in cases with microsatellite instability (MSI) but is ineffective for the microsatellite stable (MSS)…

Computer Vision and Pattern Recognition · Computer Science 2024-11-13 Hadar Hezi , Matan Gelber , Alexander Balabanov , Yosef E. Maruvka , Moti Freiman

An important task at the onset of a laparoscopic cholecystectomy (LC) operation is the inspection of gallbladder (GB) to evaluate the thickness of its wall, presence of inflammation and extent of fat. Difficulty in visualization of the GB…

Computer Vision and Pattern Recognition · Computer Science 2021-07-29 C. Loukas , A. Gazis , D. Schizas

Multimodal large language models (MLLMs) have enormous potential to perform few-shot in-context learning in the context of medical image analysis. However, safe deployment of these models into real-world clinical practice requires an…

Image and Video Processing · Electrical Eng. & Systems 2025-07-22 Xing Shen , Justin Szeto , Mingyang Li , Hengguan Huang , Tal Arbel

Multimodal federated learning enables privacy-preserving collaborative model training across healthcare institutions. However, a fundamental challenge arises from modality heterogeneity: many clinical sites possess only a subset of…

Image and Video Processing · Electrical Eng. & Systems 2026-04-15 Nafis Fuad Shahid , Maroof Ahmed , Md Akib Haider , Saidur Rahman Sagor , Aashnan Rahman , Md Azam Hossain

Single-cell datasets often lack individual cell labels, making it challenging to identify cells associated with disease. To address this, we introduce Mixture Modeling for Multiple Instance Learning (MMIL), an expectation maximization…

Quantitative Methods · Quantitative Biology 2024-06-13 Erin Craig , Timothy Keyes , Jolanda Sarno , Maxim Zaslavsky , Garry Nolan , Kara Davis , Trevor Hastie , Robert Tibshirani