Related papers: How Well Do LLMs Understand Drug Mechanisms? A Kno…

Large Language Models (LLMs) are increasingly adopted for applications in healthcare, reaching the performance of domain experts on tasks such as question answering and document summarisation. Despite their success on these tasks, it is…

Drug-drug interaction (DDI) prediction is critical for treatment safety. While large language models (LLMs) show promise in pharmaceutical tasks, their effectiveness in DDI prediction remains challenging. Inspired by the well-established…

Background: Identification of the interactions and regulatory relations between biomolecules play pivotal roles in understanding complex biological systems and the mechanisms underlying diverse biological functions. However, the collection…

Large language models (LLMs) have shown remarkable performance on a variety of NLP tasks, and are being rapidly adopted in a wide range of use cases. It is therefore of vital importance to holistically evaluate the factuality of their…

Large language models (LLMs) have achieved strong performance on medical exam-style tasks, motivating growing interest in their deployment in real-world clinical settings. However, clinical decision-making is inherently safety-critical,…

Understanding how Large Language Models (LLMs) perform logical reasoning internally remains a fundamental challenge. While prior mechanistic studies focus on identifying taskspecific circuits, they leave open the question of what…

Large language models (LLMs) excel on a variety of reasoning benchmarks, but previous studies suggest they sometimes struggle to generalize to unseen questions, potentially due to over-reliance on memorized training examples. However, the…

This study investigates the efficacy of Large Language Models (LLMs) in causal discovery. Using newly available open-source LLMs, OLMo and BLOOM, which provide access to their pre-training corpora, we investigate how LLMs address causal…

Large Language Models (LLMs) excel in diverse areas, yet struggle with complex scientific reasoning, especially in the field of chemistry. Different from the simple chemistry tasks (e.g., molecule classification) addressed in previous…

One of the major barriers to using large language models (LLMs) in medicine is the perception they use uninterpretable methods to make clinical decisions that are inherently different from the cognitive processes of clinicians. In this…

The recent advent of reasoning models like OpenAI's o1 was met with excited speculation by the AI community about the mechanisms underlying these capabilities in closed models, followed by a rush of replication efforts, particularly from…

Large Language Models (LLMs) trained via Reinforcement Learning (RL) have recently achieved impressive results on reasoning benchmarks. Yet, growing evidence shows that these models often generate longer but ineffective chains of thought…

Large language models (LLMs) have revolutionized many areas (e.g. natural language processing, software engineering, etc.) by achieving state-of-the-art performance on extensive downstream tasks. Aiming to achieve robust and general…

Reasoning-enabled large language models (LLMs) excel in logical tasks, yet their utility for evaluating natural language generation remains unexplored. This study systematically compares reasoning LLMs with non-reasoning counterparts across…

Recent advancements in reasoning-enhanced large language models (LLMs), such as DeepSeek-R1 and OpenAI-o3, have demonstrated significant progress. However, their application in professional medical contexts remains underexplored,…

The rapid development of large reasoning models (LRMs), such as OpenAI-o3 and DeepSeek-R1, has led to significant improvements in complex reasoning over non-reasoning large language models~(LLMs). However, their enhanced capabilities,…

Large language models (LLMs) have demonstrated great potential for domain-specific applications, such as the law domain. However, recent disputes over GPT-4's law evaluation raise questions concerning their performance in real-world legal…

Predicting enzymatic reactions is crucial for applications in biocatalysis, metabolic engineering, and drug discovery, yet it remains a complex and resource-intensive task. Large Language Models (LLMs) have recently demonstrated remarkable…

Ongoing breakthroughs in large language models (LLMs) are reshaping scholarly search and discovery interfaces. While these systems offer new possibilities for navigating scientific knowledge, they also raise concerns about fairness and…

General-purpose large language models (LLMs) that rely on in-context learning do not reliably deliver the scientific understanding and performance required for drug discovery tasks. Simply increasing model size or introducing reasoning…