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Early diagnosis and discovery of therapeutic drug targets are crucial objectives for effective management of Alzheimer's Disease (AD). Current approaches for AD diagnosis and treatment planning are based on radiological imaging and largely…

Machine Learning · Computer Science 2026-05-01 Maryam Khalid , Fadeel Sher Khan , John Broussard , Arko Barman

Alzheimer's disease (AD) is a complex neurodegenerative disorder that affects millions of people worldwide. Due to the heterogeneous nature of AD, its diagnosis and treatment pose critical challenges. Consequently, there is a growing…

Machine Learning · Computer Science 2024-10-08 Tianyi Wei , Shu Yang , Davoud Ataee Tarzanagh , Jingxuan Bao , Jia Xu , Patryk Orzechowski , Joost B. Wagenaar , Qi Long , Li Shen

Cognitive decline is a sign of Alzheimer's disease (AD), and there is evidence that tracking a person's eye movement, using eye tracking devices, can be used for the automatic identification of early signs of cognitive decline. However,…

Computation and Language · Computer Science 2019-10-02 Bahman Mirheidari , Yilin Pan , Traci Walker , Markus Reuber , Annalena Venneri , Daniel Blackburn , Heidi Christensen

Alzheimer's disease (AD) is an irreversible devastative neurodegenerative disorder associated with progressive impairment of memory and cognitive functions. Its early diagnosis is crucial for the development of possible future treatment…

Computer Vision and Pattern Recognition · Computer Science 2020-04-07 Ahsan Bin Tufail , Qiu-Na Zhang , Yong-Kui Ma

The average life expectancy is increasing globally due to advancements in medical technology, preventive health care, and a growing emphasis on gerontological health. Therefore, developing technologies that detect and track aging-associated…

Computational Engineering, Finance, and Science · Computer Science 2022-09-14 Saurav K. Aryal , Howard Prioleau , Legand Burge

Machine learning approaches for Alzheimer's disease (AD) diagnosis face a fundamental challenges. Clinical assessments are expensive and invasive, leaving ground truth labels available for only a fraction of neuroimaging datasets. We…

Machine Learning · Computer Science 2026-03-23 Alireza Moayedikia , Sara Fin

Introduction- This paper mainly describes a way to detect with high accuracy patients with early-stage Alzheimer's disease (ES-AD) versus healthy control (HC) subjects, from datasets built with handwriting and drawing task records. Method-…

Machine Learning · Computer Science 2021-03-19 Alain Petrowski

Early diagnosis of Alzheimer's disease (AD) is essential in preventing the disease's progression. Therefore, detecting AD from neuroimaging data such as structural magnetic resonance imaging (sMRI) has been a topic of intense investigation…

Computer Vision and Pattern Recognition · Computer Science 2023-02-01 Maha M. Alwuthaynani , Zahraa S. Abdallah , Raul Santos-Rodriguez

Alzheimer's disease (AD) is a prevalent and debilitating neurodegenerative disorder impacting a large aging population. Detecting AD in all its presymptomatic and symptomatic stages is crucial for early intervention and treatment. An active…

Computer Vision and Pattern Recognition · Computer Science 2023-10-31 Yasmine Mustafa , Tie Luo

We present our submission to the ICASSP-SPGC-2023 ADReSS-M Challenge Task, which aims to investigate which acoustic features can be generalized and transferred across languages for Alzheimer's Disease (AD) prediction. The challenge consists…

Computation and Language · Computer Science 2025-01-14 Xuchu Chen , Yu Pu , Jinpeng Li , Wei-Qiang Zhang

Quantum machine learning is a new research field combining quantum information science and machine learning. Quantum computing technologies appear to be particularly well-suited for addressing problems in the health sector efficiently. They…

Emerging Technologies · Computer Science 2024-12-24 Giacomo Cappiello , Filippo Caruso

Alzheimer s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, where early detection is essential for timely intervention and improved patient outcomes. Traditional diagnostic methods are…

Alzheimer's disease (AD) constitutes a complex neurocognitive disease and is the main cause of dementia. Although many studies have been proposed targeting at diagnosing dementia through spontaneous speech, there are still limitations.…

Computation and Language · Computer Science 2023-08-24 Loukas Ilias , Dimitris Askounis

Alzheimer's disease (AD) is a neurodegenerative disorder affecting millions worldwide, necessitating early and accurate diagnosis for optimal patient management. In recent years, advancements in deep learning have shown remarkable potential…

Image and Video Processing · Electrical Eng. & Systems 2025-01-28 Taymaz Akan , Sait Alp , Md. Shenuarin Bhuiyan , Elizabeth A. Disbrow , Steven A. Conrad , John A. Vanchiere , Christopher G. Kevil , Mohammad A. N. Bhuiyan

Alzheimer's Disease (AD) is a non-curable progressive neurodegenerative disorder that affects the human brain, leading to a decline in memory, cognitive abilities, and eventually, the ability to carry out daily tasks. Manual diagnosis of…

Image and Video Processing · Electrical Eng. & Systems 2024-09-13 Santanu Roy , Archit Gupta , Shubhi Tiwari , Palak Sahu

Objective: this study has a twofold goal. First, it aims to improve the understanding of the impact of Dementia of type Alzheimer's Disease (AD) on different aspects of the lexicon. Second, it aims to demonstrate that such aspects of the…

Computation and Language · Computer Science 2023-07-18 M. Zakaria Kurdi

Alzheimer's disease (AD), characterized by progressive cognitive decline and memory loss, presents a formidable global health challenge, underscoring the critical importance of early and precise diagnosis for timely interventions and…

Image and Video Processing · Electrical Eng. & Systems 2024-10-01 Arindam Majee , Avisek Gupta , Sourav Raha , Swagatam Das

Using kinematic properties of handwriting to support the diagnosis of neurodegenerative disease is a real challenge: non-invasive detection techniques combined with machine learning approaches promise big steps forward in this research…

Computation and Language · Computer Science 2024-01-08 Nicole Dalia Cilia , Claudio De Stefano , Francesco Fontanella , Sabato Marco Siniscalchi

Alzheimer's disease (AD) progression follows a complex continuum from normal cognition (NC) through mild cognitive impairment (MCI) to dementia, yet most deep learning approaches oversimplify this into discrete classification tasks. This…

Image and Video Processing · Electrical Eng. & Systems 2025-08-05 Yufeng Jiang , Hexiao Ding , Hongzhao Chen , Jing Lan , Xinzhi Teng , Gerald W. Y. Cheng , Zongxi Li , Haoran Xie , Jung Sun Yoo , Jing Cai

Alzheimer's disease (AD) is a major neurodegenerative condition that affects millions around the world. As one of the main biomarkers in the AD diagnosis procedure, brain amyloid positivity is typically identified by positron emission…

Image and Video Processing · Electrical Eng. & Systems 2026-03-10 Yanxi Chen , Mohammad Farazi , Zhangsihao Yang , Yonghui Fan , Nicholas Ashton , Eric M Reiman , Yi Su , Yalin Wang