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Predicting the effects of chemical and genetic perturbations on quantitative cell states is a central challenge in computational biology, molecular medicine and drug discovery. Recent work has leveraged large-scale single-cell data and…

Machine Learning · Computer Science 2026-03-16 Michael Scholkemper , Sach Mukherjee

Model explainability is essential for the creation of trustworthy Machine Learning models in healthcare. An ideal explanation resembles the decision-making process of a domain expert and is expressed using concepts or terminology that is…

Machine Learning · Computer Science 2021-07-14 Sumedha Singla , Stephen Wallace , Sofia Triantafillou , Kayhan Batmanghelich

Climate models are essential to understand and project climate change, yet long-standing biases and uncertainties in their projections remain. This is largely associated with the representation of subgrid-scale processes, particularly…

We introduce a causal modeling framework that captures the input-output behavior of predictive models (e.g., machine learning models). The framework enables us to identify features that directly cause the predictions, which has broad…

Machine Learning · Computer Science 2025-05-20 Yizuo Chen , Amit Bhatia

This paper focuses on causal representation learning (CRL) under a general nonparametric latent causal model and a general transformation model that maps the latent data to the observational data. It establishes identifiability and…

Machine Learning · Computer Science 2024-02-15 Burak Varıcı , Emre Acartürk , Karthikeyan Shanmugam , Ali Tajer

Multimodal affective computing aims to predict humans' sentiment, emotion, intention, and opinion using language, acoustic, and visual modalities. However, current models often learn spurious correlations that harm generalization under…

Machine Learning · Computer Science 2026-04-21 Sijie Mai , Shiqin Han

To make effective decisions, it is important to have a thorough understanding of the causal relationships among actions, environments, and outcomes. This review aims to surface three crucial aspects of decision-making through a causal lens:…

Machine Learning · Statistics 2026-04-22 Lin Ge , Hengrui Cai , Runzhe Wan , Yang Xu , Rui Song

Discovering the underlying dynamics of complex systems from data is an important practical topic. Constrained optimization algorithms are widely utilized and lead to many successes. Yet, such purely data-driven methods may bring about…

Dynamical Systems · Mathematics 2023-05-17 Nan Chen , Yinling Zhang

A typical problem in causal modeling is the instability of model structure learning, i.e., small changes in finite data can result in completely different optimal models. The present work introduces a novel causal modeling algorithm for…

Many real-world systems can be usefully represented as sets of interacting components. Examples include computational systems, such as query processors and compilers, natural systems, such as cells and ecosystems, and social systems, such…

Artificial Intelligence · Computer Science 2025-03-18 Purva Pruthi , David Jensen

Physical and optical factors interacting with sensor characteristics create complex image degradation patterns. Despite advances in deep learning-based super-resolution, existing methods overlook the causal nature of degradation by adopting…

Computer Vision and Pattern Recognition · Computer Science 2025-01-28 Zhengyang Lu , Bingjie Lu , Feng Wang

We describe basic ideas underlying research to build and understand artificially intelligent systems: from symbolic approaches via statistical learning to interventional models relying on concepts of causality. Some of the hard open…

Artificial Intelligence · Computer Science 2022-04-04 Bernhard Schölkopf , Julius von Kügelgen

Deep learning has been the subject of growing interest in recent years. Specifically, a specific type called Multimodal learning has shown great promise for solving a wide range of problems in domains such as language, vision, audio, etc.…

Machine Learning · Computer Science 2022-11-30 Sushil Thapa

A fundamental challenge of recommendation systems (RS) is understanding the causal dynamics underlying users' decision making. Most existing literature addresses this problem by using causal structures inferred from domain knowledge.…

Information Retrieval · Computer Science 2022-10-20 Shuyuan Xu , Da Xu , Evren Korpeoglu , Sushant Kumar , Stephen Guo , Kannan Achan , Yongfeng Zhang

Causal structure learning with data from multiple contexts carries both opportunities and challenges. Opportunities arise from considering shared and context-specific causal graphs enabling to generalize and transfer causal knowledge across…

Machine Learning · Computer Science 2024-10-29 Martin Rabel , Wiebke Günther , Jakob Runge , Andreas Gerhardus

Estimating causal effects is vital for decision making. In standard causal effect estimation, treatments are usually binary- or continuous-valued. However, in many important real-world settings, treatments can be structured,…

Machine Learning · Statistics 2024-12-02 Oriol Corcoll Andreu , Athanasios Vlontzos , Michael O'Riordan , Ciaran M. Gilligan-Lee

Causal inference and model interpretability research are gaining increasing attention, especially in the domains of healthcare and bioinformatics. Despite recent successes in this field, decorrelating features under nonlinear environments…

Machine Learning · Computer Science 2022-09-30 Junda Wang , Weijian Li , Han Wang , Hanjia Lyu , Caroline Thirukumaran , Addisu Mesfin , Jiebo Luo

Research in Cognitive Science suggests that humans understand and represent knowledge of the world through causal relationships. In addition to observations, they can rely on experimenting and counterfactual reasoning -- i.e. referring to…

Artificial Intelligence · Computer Science 2021-05-24 Kanvaly Fadiga , Etienne Houzé , Ada Diaconescu , Jean-Louis Dessalles

Deep learning has become the dominant approach for creating high capacity, scalable models across diverse data modalities. However, because these models rely on a large number of learned parameters, tightly couple feature extraction with…

Artificial Intelligence · Computer Science 2026-05-12 Adam Gould , Francesca Toni

Despite the major advances taken in causal modeling, causality is still an unfamiliar topic for many statisticians. In this paper, it is demonstrated from the beginning to the end how causal effects can be estimated from observational data…

Methodology · Statistics 2014-07-03 Juha Karvanen
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