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The microservices architectural style has become the de facto standard for large-scale cloud applications, offering numerous benefits in scalability, maintainability, and deployment flexibility. Many organizations are pursuing the migration…

Software Engineering · Computer Science 2025-03-28 Matthéo Lecrivain , Hanifa Barry , Dalila Tamzalit , Houari Sahraoui

Mathematical models are increasingly used in both academia and the pharmaceutical industry to understand how phenotypes emerge from systems of molecular interactions. However, their current construction as monolithic sets of equations…

Molecular Networks · Quantitative Biology 2007-10-19 Aneil Mallavarapu , Matthew Thomson , Benjamin Ullian , Jeremy Gunawardena

Continuous Architecture (CA) is an approach that supports companies in decreasing the time between deliveries. Migration to microservices is one of the most common situations when companies adopt continuous architecting processes [4].…

Software Engineering · Computer Science 2018-10-26 Valentina Lenarduzzi , Davide Taibi

Although species longevity is subject to a diverse range of selective forces, the mortality curves of a wide variety of organisms are rather similar. We argue that aging and its universal characteristics may have evolved by means of a…

Populations and Evolution · Quantitative Biology 2013-02-01 Dervis Can Vural , Greg Morrison , L. Mahadevan

In Method Engineering (ME) science, the key issue is the consideration of information system development methods as fragments. Numerous ME approaches have produced several definitions of method parts. Different in nature, these fragments…

Software Engineering · Computer Science 2009-11-04 Rebecca Deneckere , Adrian Iacovelli , Elena Kornyshova , Carine Souveyet

In the last few years, the cloudification of applications requires new concepts and techniques to fully reap the benefits of the new computing paradigm. Among them, the microservices architectural style, which is inspired by…

Software Engineering · Computer Science 2022-03-16 Hai Dinh-Tuan , Katerina Katsarou , Patrick Herbke

Context: Microservices Architecture (MSA) has received significant attention in the software industry. However, little empirical evidence exists on design, monitoring, and testing of microservices systems. Objective: This research aims to…

Software Engineering · Computer Science 2021-08-24 Muhammad Waseem , Peng Liang , Mojtaba Shahin , Amleto Di Salle , Gastón Márquez

Aging remains a fundamental open problem in modern biology. Although there exist a number of theories on aging on the cellular scale, nearly nothing is known about how microscopic failures cascade to macroscopic failures of tissues, organs…

Tissues and Organs · Quantitative Biology 2017-07-10 Aylin Acun , Dervis Can Vural , Pinar Zorlutuna

Network meta-analysis is an evidence synthesis method for comparing the effectiveness of multiple available treatments. To justify evidence synthesis, consistency is an important assumption; however, existing methods founded on statistical…

Methodology · Statistics 2025-04-29 Kotaro Sasaki , Hisashi Noma

This paper presents a formal approach to modelling and analysis of data and control flow dependencies between services within remotely deployed distributed systems of services. Our work aims at elaborating for a concrete system, which parts…

Software Engineering · Computer Science 2014-12-12 Maria Spichkova , Heinrich Schmidt

Microservices architectures are a departure from traditional Service Oriented Architecture (SOA). Influenced by Domain Driven Design (DDD), microservices architectures aim to help business analysts and enterprise architects develop scalable…

Software Engineering · Computer Science 2017-09-21 Dharmendra Shadija , Mo Rezai , Richard Hill

Recognising that real-world optimisation problems have multiple interdependent components can be quite easy. However, providing a generic and formal model for dependencies between components can be a tricky task. In fact, a PMIC can be…

Artificial Intelligence · Computer Science 2019-03-19 Mohamed El Yafrani

Many complex mechatronic systems consist of multiple interconnected dynamical subsystems, which are designed, developed, analyzed, and manufactured by multiple independent teams. To support such a design approach, a modular model framework…

Systems and Control · Electrical Eng. & Systems 2024-02-13 Robert A. Egelmeers , Lars A. L. Janssen , Rob H. B. Fey , Jasper Gerritsen , Nathan van de Wouw

The rapid technological advances in the Internet of Things (IoT) allows the blueprint of Smart Cities to become feasible by integrating heterogeneous cloud/fog/edge computing paradigms to collaboratively provide variant smart services in…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-04-07 Qian Qu , Ronghua Xu , Seyed Yahya Nikouei , Yu Chen

Microservice Architecture (MSA) denotes an emerging architectural style for distributed and service-based systems whereby each microservice is highly cohesive and implements a single business capability. A microservice system consists of…

Software Engineering · Computer Science 2018-05-04 Jonas Sorgalla , Florian Rademacher , Sabine Sachweh , Albert Zündorf

Cloud applications are moving away from monolithic model towards loosely-coupled microservices designs. Service meshes are widely used for implementing microservices applications mainly because they provide a modular architecture for modern…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-10-19 Prateek Sahu , Lucy Zheng , Marco Bueso , Shijia Wei , Neeraja J. Yadwadkar , Mohit Tiwari

This paper proposes an intelligent service optimization method based on a multi-agent collaborative evolution mechanism to address governance challenges in large-scale microservice architectures. These challenges include complex service…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-08-29 Yilin Li , Song Han , Sibo Wang , Ming Wang , Renzi Meng

Context: Several companies are migrating their information systems into the Cloud. Microservices and DevOps are two of the most common adopted technologies. However, there is still a lack of understanding how to adopt a microservice-based…

Software Engineering · Computer Science 2019-08-28 Davide Taibi , Valentina Lenarduzzi , Claus Pahl

Machine learning is now a central part of how modern systems are built and used, powering everything from personalized recommendations to large-scale business analytics. As its role grows, organizations are facing new challenges in…

Software Engineering · Computer Science 2026-03-17 Sowjanya Karanam , Jayanth Bhargav

The cloud is a new paradigm that is paving the way for new approaches and standards. The architectural styles are evolving in response to the cloud's requirements. In recent years, microservices have emerged as the preferred architectural…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-10-11 A. N. M. Sajedul Alam , Junaid Bin Kibria , Al Hasib Mahamud , Arnob Kumar Dey , Hasan Muhammed Zahidul Amin , Md Sabbir Hossain , Annajiat Alim Rasel
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