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As large language models (LLMs) develop increasingly sophisticated capabilities and find applications in medical settings, it becomes important to assess their medical safety due to their far-reaching implications for personal and public…

Artificial Intelligence · Computer Science 2024-10-11 Tessa Han , Aounon Kumar , Chirag Agarwal , Himabindu Lakkaraju

The rapid advancement of large language models (LLMs) has accelerated their integration into clinical decision support, particularly in prescription review. To enable systematic and fine-grained evaluation, we developed RxBench, a…

Computation and Language · Computer Science 2025-12-03 Yan Yang , Mouxiao Bian , Peiling Li , Bingjian Wen , Ruiyao Chen , Kangkun Mao , Xiaojun Ye , Tianbin Li , Pengcheng Chen , Bing Han , Jie Xu , Kaifeng Qiu , Junyan Wu

As the performance of large language models (LLMs) continues to advance, their adoption in the medical domain is increasing. However, most existing risk evaluations largely focused on general safety benchmarks. In the medical applications,…

Computation and Language · Computer Science 2026-01-12 Jean-Philippe Corbeil , Minseon Kim , Maxime Griot , Sheela Agarwal , Alessandro Sordoni , Francois Beaulieu , Paul Vozila

Millions of individuals' well-being are challenged by the harms of substance use. Harm reduction as a public health strategy is designed to improve their health outcomes and reduce safety risks. Some large language models (LLMs) have…

Computation and Language · Computer Science 2025-07-30 Kaixuan Wang , Chenxin Diao , Jason T. Jacques , Zhongliang Guo , Shuai Zhao

With the rapid development of large language models (LLMs), assessing their performance on health-related inquiries has become increasingly essential. The use of these models in real-world contexts-where misinformation can lead to serious…

Computation and Language · Computer Science 2025-02-24 Chenlu Guo , Nuo Xu , Yi Chang , Yuan Wu

With the growing prevalence of large language models (LLMs), the safety of LLMs has raised significant concerns. However, there is still a lack of definitive standards for evaluating their safety due to the subjective nature of current…

Computation and Language · Computer Science 2025-06-10 Chuxue Cao , Han Zhu , Jiaming Ji , Qichao Sun , Zhenghao Zhu , Yinyu Wu , Juntao Dai , Yaodong Yang , Sirui Han , Yike Guo

Artificial Intelligence (AI) is revolutionizing scientific research, yet its growing integration into laboratory environments presents critical safety challenges. Large language models (LLMs) and vision language models (VLMs) now assist in…

The advancement and extensive application of large language models (LLMs) have been remarkable, including their use in scientific research assistance. However, these models often generate scientifically incorrect or unsafe responses, and in…

Computation and Language · Computer Science 2024-11-28 Haochen Zhao , Xiangru Tang , Ziran Yang , Xiao Han , Xuanzhi Feng , Yueqing Fan , Senhao Cheng , Di Jin , Yilun Zhao , Arman Cohan , Mark Gerstein

Multimodal Large Language Models (MLLMs) are showing strong safety concerns (e.g., generating harmful outputs for users), which motivates the development of safety evaluation benchmarks. However, we observe that existing safety benchmarks…

Cryptography and Security · Computer Science 2024-10-25 Zonghao Ying , Aishan Liu , Siyuan Liang , Lei Huang , Jinyang Guo , Wenbo Zhou , Xianglong Liu , Dacheng Tao

With the proliferation of Large Language Models (LLMs) in diverse domains, there is a particular need for unified evaluation standards in clinical medical scenarios, where models need to be examined very thoroughly. We present CliMedBench,…

Computation and Language · Computer Science 2024-10-07 Zetian Ouyang , Yishuai Qiu , Linlin Wang , Gerard de Melo , Ya Zhang , Yanfeng Wang , Liang He

Evaluating large language models (LLMs) in medicine is crucial because medical applications require high accuracy with little room for error. Current medical benchmarks have three main types: medical exam-based, comprehensive medical, and…

The security concerns surrounding Large Language Models (LLMs) have been extensively explored, yet the safety of Multimodal Large Language Models (MLLMs) remains understudied. In this paper, we observe that Multimodal Large Language Models…

Computer Vision and Pattern Recognition · Computer Science 2024-06-21 Xin Liu , Yichen Zhu , Jindong Gu , Yunshi Lan , Chao Yang , Yu Qiao

The deployment of Large Language Models (LLMs) in high-stakes clinical settings demands rigorous and reliable evaluation. However, existing medical benchmarks remain static, suffering from two critical limitations: (1) data contamination,…

Artificial Intelligence · Computer Science 2026-02-12 Zhiling Yan , Dingjie Song , Zhe Fang , Yisheng Ji , Xiang Li , Quanzheng Li , Lichao Sun

While Large Language Models (LLMs) excel on standardized medical exams, high scores often fail to translate to high-quality responses for real-world medical queries. Current evaluations rely heavily on multiple-choice questions, failing to…

Large language models (LLMs) show significant potential in healthcare, prompting numerous benchmarks to evaluate their capabilities. However, concerns persist regarding the reliability of these benchmarks, which often lack clinical…

Computation and Language · Computer Science 2026-04-30 Wenting Chen , Guo Yu , Yiu-Fai Cheung , Meidan Ding , Jie Liu , Zizhan Ma , Wenxuan Wang , Linlin Shen

Medical question answering (QA) benchmarks often focus on multiple-choice or fact-based tasks, leaving open-ended answers to real patient questions underexplored. This gap is particularly critical in mental health, where patient questions…

Computation and Language · Computer Science 2026-05-15 Yahan Li , Jifan Yao , John Bosco S. Bunyi , Adam C. Frank , Angel Hsing-Chi Hwang , Ruishan Liu

Large language models (LLMs) often match or exceed clinician-level performance on medical benchmarks, yet very few are evaluated on real clinical data or examined beyond headline metrics. We present, to our knowledge, the first evaluation…

With the rapid development of Large Language Models (LLMs), increasing attention has been paid to their safety concerns. Consequently, evaluating the safety of LLMs has become an essential task for facilitating the broad applications of…

Computation and Language · Computer Science 2024-06-25 Zhexin Zhang , Leqi Lei , Lindong Wu , Rui Sun , Yongkang Huang , Chong Long , Xiao Liu , Xuanyu Lei , Jie Tang , Minlie Huang

Large Language Models (LLMs) have demonstrated impressive capabilities across various specialist domains and have been integrated into high-stakes areas such as medicine. However, as existing medical-related benchmarks rarely stress-test…

Computation and Language · Computer Science 2026-03-26 Lin Yang , Yuancheng Yang , Xu Wang , Changkun Liu , Haihua Yang

The remarkable capabilities of Large Language Models (LLMs) make them increasingly compelling for adoption in real-world healthcare applications. However, the risks associated with using LLMs in medical applications have not been…

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