Related papers: Microfluidic platform for biomimetic tissue design…
Fluidic devices are crucial components in many industrial applications involving fluid mechanics. Computational design of a high-performance fluidic system faces multifaceted challenges regarding its geometric representation and physical…
This study introduces an open-source computational framework for the generation and permeability evaluation of synthetic porous media. The proposed methodology integrates crystallographic and meshing tools to construct controlled…
This work presents a novel unfitted finite element framework to simulate coupled surface-bulk problems in time-dependent domains, focusing on fluid-fluid interactions in animal cells between the actomyosin cortex and the cytoplasm. The…
We present a framework for modeling liver regrowth on the organ scale that is based on three components: (1) a multiscale perfusion model that combines synthetic vascular tree generation with a multi-compartment homogenized flow model,…
Microcapsules with liquid cores encapsulated by thin membranes have many applications in science, medicine and industry. In this paper, we design a suspension of microcapsules which flow and deform like red blood cells (RBCs), as a valuable…
Unlike human intestines, which are long, hollow tubes, the intestines of sharks and rays contain interior helical structures surrounding a cylindrical hole. One function of these structures may be to create asymmetric flow, favoring passage…
We present a methodology for simulating three-dimensional flow of incompressible viscoplastic fluids modelled by generalised Newtonian rheological equations. It is implemented in a highly efficient framework for massively parallelisable…
The internal and external mechanical environment plays an important role in tumorogenesis. As a proxy of an avascular early state tumor, we use multicellular spheroids, a composite material made of cells, extracellular matrix and permeating…
In Part I of this article we have developed a novel mechanobiological model of a Tissue Engineering process that accounts for the mechanisms through which an isotropic or anisotropic adherence condition regulates the active functions of the…
This paper delineates the formulation and verification of an innovative robotic forearm and elbow design, mirroring the intricate biomechanics of human skeletal and ligament systems. Conventional robotic models often undervalue the…
Soft lubricated contacts exhibit complex interfacial behaviours governed by the coupled effects of multiscale surface roughness and non-linear fluid-solid interactions. Accurately capturing this interplay across thin-film flows is…
We have designed and fabricated a microfluidic-based platform for sensing mechanical forces generated by cardiac microtissues in a highly-controlled microenvironment. Our fabrication approach combines Direct Laser Writing (DLW) lithography…
Performing cell-free expression (CFE) in tailored microfluidic environments is a powerful tool to investigate the organisation of biosystems from molecular to multicellular scales. While cell-free transcription-translation systems simplify…
A fully coupled implicit finite-volume algorithm for incompressible viscoelastic interfacial flows is proposed, whereby the viscoelasticity of the flow is described by an upper-convected Maxwell constitutive model, including limited…
We study the particle-scale dynamics that give rise to bulk flow behaviours of highly concentrated particle-fluid mixtures using discrete element method (DEM) simulations. We utilize boundary conditions of a stress-controlled shear cell and…
The dynamics of active viscoelastic surfaces plays an important role in biological systems. One prominent example is the actin cortex, a thin bio-polymer sheet underneath the outer membrane of biological cells which combines active…
We have designed optical metasurfaces hosting high-quality factor quasi-bound state in the continuum (q-BIC) resonances for optical biosensing in flow. The unit cell of the metasurface contains two rectangular bars. An asymmetry factor is…
This paper critically analyzes conventional and biomimetic robotic arms, underscoring the trade-offs between size, motion range, and load capacity in current biomimetic models. By delving into the human shoulder's mechanical intelligence,…
Coupling between flows and material properties imbues rheological matter with its wide-ranging applicability, hence the excitement for harnessing the rheology of active fluids for which internal structure and continuous energy injection…
Ferrohydrodynamic microfluidics relies on magnetic field gradients to manipulate diamagnetic particles in ferrofluid-filled microenvironments. It has emerged as a promising tool for label-free manipulation of bioparticles, including their…