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Engineering simple, artificial models of living cells allows synthetic biologists to study cellular functions under well-controlled conditions. Reconstituting multicellular behaviors with synthetic cell-mimics is still a challenge because…

Biomolecules · Quantitative Biology 2021-04-29 Imre Banlaki , Francois-Xavier Lehr , Henrike Niederholtmeyer

Model biomembrane systems play a crucial role in advancing biomedical research by providing simplified yet effective platforms for exploring complex biological mechanisms. These systems span a wide range of scales, from…

Soft Condensed Matter · Physics 2025-10-01 Ajit Seth , Sajal K. Ghosh , Veerendra K. Sharma

Microfluidic valves play a key role within microfluidic systems by regulating fluid flow through distinct microchannels, enabling many advanced applications in medical diagnostics, lab-on-chips, and laboratory automation. While microfluidic…

Materials Science · Physics 2023-12-19 Tinku Supakar , David Space , Sophy Meija , Rou Yu Tan , Jeffrey R. Alston , Eric A. Josephs

Cell shape changes, essential for processes such as motility or division, are controlled by the actomyosin cortex that actively remodels biological membranes. Their mechanisms can be deciphered in___vitro using biomimetic reconstituted…

Microfluidic channels have emerged as useful tools to control dynamic forcing on transported microscale objects, as encountered in emulsions, biological flows, and other soft matter systems. Tailored channel designs enable precise…

Soft Condensed Matter · Physics 2026-05-29 Matteo Milani , Joshua D. McGraw , Anke Lindner Stefano Aime

High-density microfluidics is becoming an important experimental platform for studying complex biological systems such as synthetic gene regulatory networks, molecular biocomputating of engineered cells, distributing rapid point-of-care…

Biological Physics · Physics 2021-07-21 Sankar Raju Narayanasamy , Ramakrishna Vasireddi , Hoi-Ying Holman

Mathematical models and numerical simulations are widely used in the field of hemodynamics, representing a valuable resource to better understand physiological and pathological processes. The theory behind the phenomenon is closely related…

Fluid Dynamics · Physics 2021-06-15 Giulia Bertaglia , Valerio Caleffi , Alessandro Valiani

Microfluidic multipoles (MFMs) have been realized experimentally and hold promise for "open-space" biological and chemical surface processing. Whereas convective flow can readily be predicted using hydraulic-electrical analogies, the design…

Multiphase systems are ubiquitous in engineering, biology, and materials science, where understanding their complex interactions and rheological behavior is crucial for advancing applications ranging from emulsion stability to cellular…

Fluid Dynamics · Physics 2025-10-27 Andres Santiago Espinosa-Moreno , Nicolas Moreno , Marco Ellero

Microfluidic devices are increasingly used in biological and chemical experiments due to their cost-effectiveness for rheological estimation in fluids. However, these devices often face challenges in terms of accuracy, size, and cost. This…

In the application of underwater creature study, comparing with propeller-powered ROVs and servo motor actuated robotic fish, novel biomimetic fish robot designs with soft actuation structure could interact with aquatic creatures closely…

Robotics · Computer Science 2021-10-15 Ningzhe Hou

This chapter presents an overview of microfluidic devices reported in the literature, used to develop methodologies for nucleation of biomolecules, with crystal size control, and for collecting thermodynamic and kinetic data. Part I is…

Soft Condensed Matter · Physics 2025-12-16 Nadine Candoni , Romain Grossier , Stéphane Veesler

In this paper, a multiscale constitutive framework for one-dimensional blood flow modeling is presented and discussed. By analyzing the asymptotic limits of the proposed model, it is shown that different types of blood propagation phenomena…

Numerical Analysis · Mathematics 2023-12-13 Giulia Bertaglia , Lorenzo Pareschi

A rising wave of technologies and instruments are enabling more labs and clinics to make a variety of measurements related to tissue viscoelastic properties. These instruments include elastography imaging scanners, rheological shear…

Tissues and Organs · Quantitative Biology 2024-08-30 Kevin J. Parker , Thomas Szabo , Sverre Holm

We investigate the nonlinear viscoelastic behavior of a biomimetic scale-covered beam in which shear-dependent complex fluids are trapped between overlapping scales under bending loads. These fluids mimic biological mucus and slime layers…

Soft Condensed Matter · Physics 2025-05-29 Pranta Rahman Sarkar , Outi Tammisola , Ranajay Ghosh

The transport and manipulation of particles and cells in microfluidic devices has become a core methodology in domains ranging from molecular biology to manufacturing and drug design. The rational design and operation of such devices can…

Computational Engineering, Finance, and Science · Computer Science 2020-07-15 Dmitry Alexeev , Lucas Amoudruz , Sergey Litvinov , Petros Koumoutsakos

The human joint is an open-type joint composed of bones, cartilage, ligaments, synovial fluid, and joint capsule, having advantages of flexibility and impact resistance. However, replicating this structure in robots introduces friction…

Giant micelles are elongated, polymer-like objects created by the self-assembly of amphiphilic molecules (such as detergents) in solution. Giant micelles are typically flexible, and can become highly entangled even at modest concentrations.…

Soft Condensed Matter · Physics 2007-05-23 Michael E. Cates , Suzanne M. Fielding

Integrated micro-nanochannel networks in fluidic devices are desirable in a number of applications ranging from self-healing/cooling materials to bioengineering. The conventional micro-manufacturing techniques are capable of either…

Materials Science · Physics 2017-04-10 Prasoon Kumar , Prasanna S Gandhi , Mainak Majumder

Our ability to produce human-scale bio-manufactured organs is critically limited by the need for vascularization and perfusion. For tissues of variable size and shape, including arbitrarily complex geometries, designing and printing…

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