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Active Brownian particles (ABPs) with pure repulsion is an ideal model to understand the effect of nonequilibrium on collective behaviors. It has long been established that activity can create effective attractions leading to…

Soft Condensed Matter · Physics 2022-04-01 Jie Su , Mengkai Feng , Huijun Jiang , Zhonghuai Hou

Dense active systems are widespread in nature, examples range from bacterial colonies to biological tissues. Dense clusters of active particles can be obtained by increasing the packing fraction of the system or taking advantage of a…

Soft Condensed Matter · Physics 2022-04-13 Matteo Paoluzzi , Demian Levis , Ignacio Pagonabarraga

Active systems, or active matter, are self-driven systems which live, or function, far from equilibrium - a paradigmatic example which we focus on here is provided by a suspension of self-motile particles. Active systems are far from…

Soft Condensed Matter · Physics 2015-05-19 Giuseppe Gonnella , Davide Marenduzzo , Antonio Suma , Adriano Tiribocchi

Chemically active droplets provide simple models for cell-like systems that can grow and divide. Such active droplet systems are driven away from thermodynamic equilibrium and turn over chemically, which corresponds to a simple metabolism.…

Biological Physics · Physics 2022-09-28 Jonathan Bauermann , Christoph A. Weber , Frank Jülicher

The formation of (bio)molecular condensates via liquid-liquid phase separation in cells has received increasing attention, as these coacervates play important functional and regulatory roles within biological systems. However, the majority…

Soft Condensed Matter · Physics 2022-11-24 Arash Nikoubashman , Miho Yanagisawa

Biomolecular condensates play a crucial role in the spatial organization of living matter. These membrane-less organelles, resulting from liquid-liquid phase separation, operate far from thermodynamic equilibrium, with their size and…

Soft Condensed Matter · Physics 2025-05-12 Jacques Fries , Roxanne Berthin , Marie Jardat , Pierre Illien , Vincent Dahirel

Liquid-liquid phase separation (LLPS) is important to control a wide range of reactions from gene expression to protein degradation in a cell-sized space. To bring a better understanding of the compatibility of such phase-separated…

Soft Condensed Matter · Physics 2021-10-01 Shuzo Kato , David Garenne , Vincent Noireaux , Yusuke T. Maeda

Living and engineered systems rely on the stable coexistence of two interspersed liquid phases. Yet surface tension drives their complete separation. Here we show that stable droplets of uniform and tuneable size can be produced through…

Liquid-liquid phase separation (LLPS) is currently of great interest in cell biology. LLPS is an example of what is called an emergent phenomenon -- an idea that comes from condensed-matter physics. Emergent phenomena have the…

Cell Behavior · Quantitative Biology 2021-03-16 Richard P Sear

In contrast to equilibrium systems, inertia can profoundly impact the phase behavior of active systems. This has been made particularly evident in recent years, with motility-induced phase separation (MIPS) exhibiting several intriguing…

Soft Condensed Matter · Physics 2025-04-21 Jiechao Feng , Ahmad K. Omar

Phase separating systems that are maintained away from thermodynamic equilibrium via molecular processes represent a class of active systems, which we call active emulsions. These systems are driven by external energy input for example…

Soft Condensed Matter · Physics 2019-06-07 Christoph A. Weber , David Zwicker , Frank Jülicher , Chiu Fan Lee

In the last decade, the study of pressure in active matter has attracted growing attention due to its fundamental relevance to nonequilibrium statistical physics. Active matter systems are composed of particles that consume energy to…

Soft Condensed Matter · Physics 2025-08-14 Guo Yu , Ruiyao Li , Fukang Li , Jiayu Zhang , Xiyue Li , Zequ Chen , Joscha Mecke , Yongxiang Gao

In this paper, we bring together our efforts in identifying and understanding nonequilibrium phase segregation driven by active processes in the living cell, with special focus on the segregation of cell membrane components driven by active…

Soft Condensed Matter · Physics 2022-05-04 Ajay Bansal , Amit Das , Madan Rao

Liquid liquid phase separation (LLPS) of proteins is an intracellular process that is widely used by cells for many purposes. In living cells (in vivo), LLPS occurs in complex and crowded environments. Amino acids (AAs) are vital components…

We theoretically study mixtures of chemically-interacting particles, which produce or consume a chemical to which they are attracted or repelled, in the most general case of many coexisting species. We find a new class of active phase…

Soft Condensed Matter · Physics 2019-07-15 Jaime Agudo-Canalejo , Ramin Golestanian

Phase separation of a liquid mixture embedded within an elastic network is relevant to a wide range of natural and industrial systems, including biomolecular condensates interacting with the cytoskeleton, structural colouring in bird…

Soft Condensed Matter · Physics 2025-08-14 Oliver W. Paulin , Yicheng Qiang , David Zwicker

Active matter systems are inherently out of equilibrium and break the detailed balance (DB) at the microscopic scale, exhibiting vital collective phenomena such as motility-induced phase separation (MIPS). Here, we introduce a…

Soft Condensed Matter · Physics 2022-11-30 Jie Su , Zhiyu Cao , Jin Wang , Huijun Jiang , Zhonghuai Hou

Phase separation, the spontaneous segregation of density, is a ubiquitous phenomenon observed across diverse physical and biological systems. Within a crowd of motile elements, active phase separation emerges from the interplay of activity…

Soft Condensed Matter · Physics 2026-01-26 Kyosuke Adachi

Microphase separation is common in active biological systems as exemplified by the separation of RNA and DNA-rich phases in the cell nucleus driven by the transcriptional activity of polymerase enzymes acting similarly to amphiphiles in a…

Soft Condensed Matter · Physics 2025-07-22 Rakesh Chatterjee , Hui-Shun Kuan , Frank Julicher , Vasily Zaburdaev

Dry active matter systems are well-known to exhibit Motility-Induced Phase Separation (MIPS). However, in wet active systems, attractive hydrodynamic interactions mediated by active particles stalled at a boundary can introduce…

Soft Condensed Matter · Physics 2026-01-01 Kingshuk Panja , Rajesh Singh