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Deep-learning-based local feature extraction algorithms that combine detection and description have made significant progress in visible image matching. However, the end-to-end training of such frameworks is notoriously unstable due to the…

Computer Vision and Pattern Recognition · Computer Science 2023-01-18 Yuxin Deng , Jiayi Ma

The accurate prediction of protein-ligand binding affinity is important for drug discovery yet remains challenging for multi-domain proteins, where inter-domain dynamics and flexible linkers govern molecular recognition. Current geometric…

Quantitative Methods · Quantitative Biology 2026-01-27 Shuo Zhang , Jian K. Liu

Many healthcare applications are inherently multimodal, involving several physiological signals. As sensors for these signals become more common, improving machine learning methods for multimodal healthcare data is crucial. Pretraining…

Machine Learning · Computer Science 2024-10-23 Ching Fang , Christopher Sandino , Behrooz Mahasseni , Juri Minxha , Hadi Pouransari , Erdrin Azemi , Ali Moin , Ellen Zippi

Identifying novel functional protein structures is at the heart of molecular engineering and molecular biology, requiring an often computationally exhaustive search. We introduce the use of a Deep Convolutional Generative Adversarial…

Biomolecules · Quantitative Biology 2021-04-20 Ethan Moyer , Jeff Winchell , Isamu Isozaki , Yigit Alparslan , Mali Halac , Edward Kim

In the realm of recommendation systems, users exhibit a diverse array of behaviors when interacting with items. This phenomenon has spurred research into learning the implicit semantic relationships between these behaviors to enhance…

Information Retrieval · Computer Science 2024-08-22 Hao Wang , Yongqiang Han , Kefan Wang , Kai Cheng , Zhen Wang , Wei Guo , Yong Liu , Defu Lian , Enhong Chen

Pre-trained multimodal models have achieved significant success in retrieval-based question answering. However, current multimodal retrieval question-answering models face two main challenges. Firstly, utilizing compressed evidence features…

Artificial Intelligence · Computer Science 2023-10-17 Shuwen Yang , Anran Wu , Xingjiao Wu , Luwei Xiao , Tianlong Ma , Cheng Jin , Liang He

Articulated human pose estimation is a fundamental yet challenging task in computer vision. The difficulty is particularly pronounced in scale variations of human body parts when camera view changes or severe foreshortening happens.…

Computer Vision and Pattern Recognition · Computer Science 2017-08-04 Wei Yang , Shuang Li , Wanli Ouyang , Hongsheng Li , Xiaogang Wang

After AlphaFold won the Nobel Prize, protein prediction with deep learning once again became a hot topic. We comprehensively explore advanced deep learning methods applied to protein structure prediction and design. It begins by examining…

Proteins perform critical processes in all living systems: converting solar energy into chemical energy, replicating DNA, as the basis of highly performant materials, sensing and much more. While an incredible range of functionality has…

Biomolecules · Quantitative Biology 2021-09-29 Leonardo V. Castorina , Rokas Petrenas , Kartic Subr , Christopher W. Wood

Multimodal knowledge graph link prediction aims to improve the accuracy and efficiency of link prediction tasks for multimodal data. However, for complex multimodal information and sparse training data, it is usually difficult to achieve…

Artificial Intelligence · Computer Science 2023-01-12 Yilin Wen , Biao Luo , Yuqian Zhao

Modern Review Helpfulness Prediction systems are dependent upon multiple modalities, typically texts and images. Unfortunately, those contemporary approaches pay scarce attention to polish representations of cross-modal relations and tend…

Computation and Language · Computer Science 2026-05-13 Thong Nguyen , Xiaobao Wu , Anh-Tuan Luu , Cong-Duy Nguyen , Zhen Hai , Lidong Bing

Despite significant progress in static protein structure collection and prediction, the dynamic behavior of proteins, one of their most vital characteristics, has been largely overlooked in prior research. This oversight can be attributed…

Biomolecules · Quantitative Biology 2024-09-19 Ce Liu , Jun Wang , Zhiqiang Cai , Yingxu Wang , Huizhen Kuang , Kaihui Cheng , Liwei Zhang , Qingkun Su , Yining Tang , Fenglei Cao , Limei Han , Siyu Zhu , Yuan Qi

Deep neural network is an effective choice to automatically recognize human actions utilizing data from various wearable sensors. These networks automate the process of feature extraction relying completely on data. However, various noises…

Signal Processing · Electrical Eng. & Systems 2021-01-05 Tanvir Mahmud , A. Q. M. Sazzad Sayyed , Shaikh Anowarul Fattah , Sun-Yuan Kung

The recent success of large foundation models in artificial intelligence has prompted the emergence of chemical pre-trained models. Despite the growing interest in large molecular pre-trained models that provide informative representations…

Machine Learning · Computer Science 2025-05-26 Jinho Chang , Jong Chul Ye

The characterization of drug-protein interactions is crucial in the high-throughput screening for drug discovery. The deep learning-based approaches have attracted attention because they can predict drug-protein interactions without…

Machine Learning · Computer Science 2020-12-22 QHwan Kim , Joon-Hyuk Ko , Sunghoon Kim , Nojun Park , Wonho Jhe

Multimodal deep learning (MDL) has emerged as a transformative approach in computational pathology. By integrating complementary information from multiple data sources, MDL models have demonstrated superior predictive performance across…

Quantitative Methods · Quantitative Biology 2025-11-17 Seth Alain Chang , Muhammad Mueez Amjad , Noorul Wahab , Ethar Alzaid , Nasir Rajpoot , Adam Shephard

Proteins are inherently multiscale physical systems whose functional properties emerge from coordinated structural organization across multiple spatial resolutions, ranging from atomic interactions to global fold topology. However, existing…

Machine Learning · Computer Science 2026-05-13 Viet Thanh Duy Nguyen , John K. Johnstone , Truong-Son Hy

Protein-protein interactions are central mediators in many biological processes. Accurately predicting the effects of mutations on interactions is crucial for guiding the modulation of these interactions, thereby playing a significant role…

Machine Learning · Computer Science 2024-05-29 Yuanle Mo , Xin Hong , Bowen Gao , Yinjun Jia , Yanyan Lan

Proteins are fundamental components of biological systems and can be represented through various modalities, including sequences, structures, and textual descriptions. Despite the advances in deep learning and scientific large language…

Machine Learning · Computer Science 2024-07-15 Zhiyuan Chen , Tianhao Chen , Chenggang Xie , Yang Xue , Xiaonan Zhang , Jingbo Zhou , Xiaomin Fang

Deep recommender systems (DRS) often face challenges in balancing computational efficiency and model accuracy, especially when handling high-dimensional input features. Existing methods either focus on improving accuracy while neglecting…

Information Retrieval · Computer Science 2026-05-08 Nghia Bui , Yue Ning , Lijing Wang