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A core challenge in structural biophysics is generating biomolecular conformations that are both physically plausible and consistent with experimental measurements. While sequence-to-structure diffusion models provide powerful priors,…

Machine Learning · Computer Science 2026-05-15 Minhuan Li , Jiequn Han , Pilar Cossio , Luhuan Wu

Recently, diffusion-based deep generative models (e.g., Stable Diffusion) have shown impressive results in text-to-image synthesis. However, current text-to-image models often require multiple passes of prompt engineering by humans in order…

Computation and Language · Computer Science 2023-11-14 Tingfeng Cao , Chengyu Wang , Bingyan Liu , Ziheng Wu , Jinhui Zhu , Jun Huang

This paper introduces the first gradient-based framework for prompt optimization in text-to-image diffusion models. We formulate prompt engineering as a discrete optimization problem over the language space. Two major challenges arise in…

Machine Learning · Computer Science 2024-07-03 Ruochen Wang , Ting Liu , Cho-Jui Hsieh , Boqing Gong

Time series prediction with deep learning methods, especially long short-term memory neural networks (LSTMs), have scored significant achievements in recent years. Despite the fact that the LSTMs can help to capture long-term dependencies,…

Machine Learning · Computer Science 2018-11-12 Youru Li , Zhenfeng Zhu , Deqiang Kong , Hua Han , Yao Zhao

Diffusion models have shown promising generative capabilities across diverse domains, yet aligning their outputs with desired reward functions remains a challenge, particularly in cases where reward functions are non-differentiable. Some…

Machine Learning · Computer Science 2025-06-04 Xiner Li , Masatoshi Uehara , Xingyu Su , Gabriele Scalia , Tommaso Biancalani , Aviv Regev , Sergey Levine , Shuiwang Ji

Diffusion models are emerging expressive generative models, in which a large number of time steps (inference steps) are required for a single image generation. To accelerate such tedious process, reducing steps uniformly is considered as an…

Computer Vision and Pattern Recognition · Computer Science 2023-09-26 Lijiang Li , Huixia Li , Xiawu Zheng , Jie Wu , Xuefeng Xiao , Rui Wang , Min Zheng , Xin Pan , Fei Chao , Rongrong Ji

Diffusion models have become a powerful backbone for text-to-image generation, producing high-quality visuals from natural language prompts. However, when prompts involve multiple objects alongside global or local style instructions, the…

Computer Vision and Pattern Recognition · Computer Science 2025-08-19 Ankit Sanjyal

Diffusion models, widely used in image generation, rely on iterative refinement to generate images from noise. Understanding this data evolution is important for model development and interpretability, yet challenging due to its…

Computer Vision and Pattern Recognition · Computer Science 2024-12-12 Vidya Prasad , Hans van Gorp , Christina Humer , Ruud J. G. van Sloun , Anna Vilanova , Nicola Pezzotti

Many global optimization algorithms of the memetic variety rely on some form of stochastic search, and yet they often lack a sound probabilistic basis. Without a recourse to the powerful tools of stochastic calculus, treading the fine…

Optimization and Control · Mathematics 2024-12-17 Rajdeep Dutta , T Venkatesh Varma , Saikat Sarkar , Mariya Mamajiwala , Noor Awad , Senthilnath Jayavelu , Debasish Roy

Building on the success of text-to-image diffusion models (DPMs), image editing is an important application to enable human interaction with AI-generated content. Among various editing methods, editing within the prompt space gains more…

Computer Vision and Pattern Recognition · Computer Science 2025-01-28 Aosong Feng , Weikang Qiu , Jinbin Bai , Xiao Zhang , Zhen Dong , Kaicheng Zhou , Rex Ying , Leandros Tassiulas

Diffusion Models represent a significant advancement in generative modeling, employing a dual-phase process that first degrades domain-specific information via Gaussian noise and restores it through a trainable model. This framework enables…

Neural and Evolutionary Computing · Computer Science 2024-11-21 Benedikt Hartl , Yanbo Zhang , Hananel Hazan , Michael Levin

Text-to-image diffusion models have shown great success in generating high-quality text-guided images. Yet, these models may still fail to semantically align generated images with the provided text prompts, leading to problems like…

Computer Vision and Pattern Recognition · Computer Science 2024-10-10 Yasi Zhang , Peiyu Yu , Ying Nian Wu

The remarkable progress in text-to-video diffusion models enables the generation of photorealistic videos, although the content of these generated videos often includes unnatural movement or deformation, reverse playback, and motionless…

Computer Vision and Pattern Recognition · Computer Science 2025-10-08 Yuta Oshima , Masahiro Suzuki , Yutaka Matsuo , Hiroki Furuta

Since the 21st century, artificial intelligence has been leading a new round of industrial revolution. Under the training framework, the optimization algorithm aims to stably converge high-dimensional optimization to local and even global…

Machine Learning · Computer Science 2025-12-02 Meng Zhu , Quan Xiao , Weidong Min

Diffusion models have demonstrated exceptional capabilities in generating high-fidelity images but typically suffer from inefficient sampling. Many solver designs and noise scheduling strategies have been proposed to dramatically improve…

Machine Learning · Statistics 2025-10-01 Tianrong Chen , Huangjie Zheng , David Berthelot , Jiatao Gu , Josh Susskind , Shuangfei Zhai

Large Language Models (LLMs) excel in various tasks, but they rely on carefully crafted prompts that often demand substantial human effort. To automate this process, in this paper, we propose a novel framework for discrete prompt…

Computation and Language · Computer Science 2025-05-02 Qingyan Guo , Rui Wang , Junliang Guo , Bei Li , Kaitao Song , Xu Tan , Guoqing Liu , Jiang Bian , Yujiu Yang

Learning from feedback has been shown to enhance the alignment between text prompts and images in text-to-image diffusion models. However, due to the lack of focus in feedback content, especially regarding the object type and quantity,…

Computer Vision and Pattern Recognition · Computer Science 2024-12-03 Xuexiang Niu , Jinping Tang , Lei Wang , Ge Zhu

Central to the application of many multi-view geometry algorithms is the extraction of matching points between multiple viewpoints, enabling classical tasks such as camera pose estimation and 3D reconstruction. Many approaches that…

Computer Vision and Pattern Recognition · Computer Science 2021-10-15 Alexander Mai , Allen Yang , Dominique E. Meyer

For the last thirty years, several Dynamic Memory Managers (DMMs) have been proposed. Such DMMs include first fit, best fit, segregated fit and buddy systems. Since the performance, memory usage and energy consumption of each DMM differs,…

Neural and Evolutionary Computing · Computer Science 2024-07-16 José L. Risco-Martín , David Atienza , J. Manuel Colmenar , Oscar Garnica

As text-to-image models grow increasingly powerful and complex, their burgeoning size presents a significant obstacle to widespread adoption, especially on resource-constrained devices. This paper presents a pioneering study on…

Computer Vision and Pattern Recognition · Computer Science 2024-11-25 Samarth N Ramesh , Zhixue Zhao