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Structural and appearance changes in brain imaging over time are crucial indicators of neurodevelopment and neurodegeneration. The rapid advancement of large-scale generative models provides a promising backbone for modeling these complex…

Graphics · Computer Science 2025-03-14 Gexin Huang , Zhangsihao Yang , Yalin Wang , Guido Gerig , Mengwei Ren , Xiaoxiao Li

Diffusion models (DMs) have recently emerged as SoTA tools for generative modeling in various domains. Standard DMs can be viewed as an instantiation of hierarchical variational autoencoders (VAEs) where the latent variables are inferred…

Computer Vision and Pattern Recognition · Computer Science 2022-10-12 Jiatao Gu , Shuangfei Zhai , Yizhe Zhang , Miguel Angel Bautista , Josh Susskind

The rapid evolution of the fashion industry increasingly intersects with technological advancements, particularly through the integration of generative AI. This study introduces a novel generative pipeline designed to transform the fashion…

Computer Vision and Pattern Recognition · Computer Science 2024-04-30 Abhishek Kumar Singh , Ioannis Patras

Diffusion generative models transform noise into data by inverting a process that progressively adds noise to data samples. Inspired by concepts from the renormalization group in physics, which analyzes systems across different scales, we…

Machine Learning · Computer Science 2024-10-04 Mathis Gerdes , Max Welling , Miranda C. N. Cheng

This paper examines three major generative modelling frameworks: Variational Autoencoders (VAEs), Generative Adversarial Networks (GANs), and Stable Diffusion models. VAEs are effective at learning latent representations but frequently…

Computer Vision and Pattern Recognition · Computer Science 2024-08-19 Sanchayan Vivekananthan

Recent advances in high-resolution sequencing have paved the way for population-scale analysis in single-cell RNA-sequencing (scRNA-seq) data. scRNA-seq data, in particular, have proven to be extremely powerful in profiling a variety of…

Methodology · Statistics 2025-10-30 Hanxuan Ye , Zachary Qian , Hongzhe Li

Latent Diffusion Models (LDM), a subclass of diffusion models, mitigate the computational complexity of pixel-space diffusion by operating within a compressed latent space constructed by Variational Autoencoders (VAEs), demonstrating…

Computer Vision and Pattern Recognition · Computer Science 2025-10-02 Arpan Mahara , Md Rezaul Karim Khan , Naphtali Rishe , Wenjia Wang , Seyed Masoud Sadjadi

Normalizing flows are a powerful class of generative models for continuous random variables, showing both strong model flexibility and the potential for non-autoregressive generation. These benefits are also desired when modeling discrete…

Machine Learning · Statistics 2019-06-06 Zachary M. Ziegler , Alexander M. Rush

Generative modeling seeks to approximate the statistical properties of real data, enabling synthesis of new data that closely resembles the original distribution. Generative Adversarial Networks (GANs) and Denoising Diffusion Probabilistic…

Computer Vision and Pattern Recognition · Computer Science 2024-07-04 Marawan Elbatel , Konstantinos Kamnitsas , Xiaomeng Li

Diffusion models have shown remarkable performance on many generative tasks. Despite recent success, most diffusion models are restricted in that they only allow linear transformation of the data distribution. In contrast, broader family of…

Machine Learning · Computer Science 2024-06-04 Grigory Bartosh , Dmitry Vetrov , Christian A. Naesseth

Controllable generation is one of the key requirements for successful adoption of deep generative models in real-world applications, but it still remains as a great challenge. In particular, the compositional ability to generate novel…

Computer Vision and Pattern Recognition · Computer Science 2021-12-07 Weili Nie , Arash Vahdat , Anima Anandkumar

The efficiency of multi-agent systems driven by large language models (LLMs) largely hinges on their communication topology. However, designing an optimal topology is a non-trivial challenge, as it requires balancing competing objectives…

Computation and Language · Computer Science 2026-05-19 Eric Hanchen Jiang , Mengting Li , Guancheng Wan , Sophia Yin , Yuchen Wu , Xiao Liang , Xinfeng Li , Yizhou Sun , Wei Wang , Kai-Wei Chang , Ying Nian Wu

Modeling the dynamics of cellular differentiation is fundamental to advancing the understanding and treatment of diseases associated with this process, such as cancer. With the rapid growth of single-cell datasets, this has also become a…

By decomposing the image formation process into a sequential application of denoising autoencoders, diffusion models (DMs) achieve state-of-the-art synthesis results on image data and beyond. Additionally, their formulation allows for a…

Computer Vision and Pattern Recognition · Computer Science 2022-04-14 Robin Rombach , Andreas Blattmann , Dominik Lorenz , Patrick Esser , Björn Ommer

In this article, we present a Latent Diffusion Model (LDM) for the generation of brain Magnetic Resonance Imaging (MRI), conditioning its generation based on pathology (Healthy, Glioblastoma, Sclerosis, Dementia) and acquisition modality…

The generation of discontinuous distributions is a difficult task for most known frameworks such as generative autoencoders and generative adversarial networks. Generative non-invertible models are unable to accurately generate such…

Machine Learning · Computer Science 2021-12-20 Mariia Drozdova , Vitaliy Kinakh , Guillaume Quétant , Tobias Golling , Slava Voloshynovskiy

In the era of generative AI, deep generative models (DGMs) with latent representations have gained tremendous popularity. Despite their impressive empirical performance, the statistical properties of these models remain underexplored. DGMs…

Machine Learning · Statistics 2025-08-07 Seunghyun Lee , Yuqi Gu

Diffusion-based representation learning has achieved substantial attention due to its promising capabilities in latent representation and sample generation. Recent studies have employed an auxiliary encoder to identify a corresponding…

Machine Learning · Computer Science 2025-03-11 Yeongmin Kim , Kwanghyeon Lee , Minsang Park , Byeonghu Na , Il-Chul Moon

Diffusion models show promise for 3D molecular generation, but face a fundamental trade-off between sampling efficiency and conformational accuracy. While flow-based models are fast, they often produce geometrically inaccurate structures,…

Chemical Physics · Physics 2025-12-05 Peining Zhang , Jinbo Bi , Minghu Song

Generative modeling and self-supervised learning have in recent years made great strides towards learning from data in a completely unsupervised way. There is still however an open area of investigation into guiding a neural network to…

Machine Learning · Computer Science 2023-05-17 Vaishnavi Patil , Matthew Evanusa , Joseph JaJa