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Molecular generative models often assume meaningful latent geometry, but apparent property predictability can reflect sequence-level shortcuts rather than chemical organization. We study this issue in an unsupervised autoregressive…

Machine Learning · Computer Science 2026-05-08 Zakaria Elabid , Jan Andrzejewski , Bartosz Brzoza , Attila Cangi

Deep generative models are increasingly becoming integral parts of the in silico molecule design pipeline and have dual goals of learning the chemical and structural features that render candidate molecules viable while also being flexible…

Biomolecules · Quantitative Biology 2021-06-08 Yair Schiff , Vijil Chenthamarakshan , Karthikeyan Natesan Ramamurthy , Payel Das

We investigate large-scale latent variable models (LVMs) for neural story generation -- an under-explored application for open-domain long text -- with objectives in two threads: generation effectiveness and controllability. LVMs,…

Computation and Language · Computer Science 2021-07-09 Le Fang , Tao Zeng , Chaochun Liu , Liefeng Bo , Wen Dong , Changyou Chen

Density estimation, compression and data generation are crucial tasks in artificial intelligence. Variational Auto-Encoders (VAEs) constitute a single framework to achieve these goals. Here, we present a novel class of generative models,…

Machine Learning · Statistics 2021-07-07 Ioannis Gatopoulos , Jakub M. Tomczak

The ability to accurately model random fields plays a critical role in science and engineering for problems involving uncertain, spatially-varying quantities such as heterogeneous material properties and turbulent flows. Deep generative…

One of the major shortcomings of variational autoencoders is the inability to produce generations from the individual modalities of data originating from mixture distributions. This is primarily due to the use of a simple isotropic Gaussian…

Machine Learning · Computer Science 2019-12-02 Frantzeska Lavda , Magda Gregorová , Alexandros Kalousis

Probabilistic generative models are attractive for scientific modeling because their inferred parameters can be used to generate hypotheses and design experiments. This requires that the learned model provide an accurate representation of…

Machine Learning · Statistics 2023-01-18 Liyun Tu , Austin Talbot , Neil Gallagher , David Carlson

We present two deep generative models based on Variational Autoencoders to improve the accuracy of drug response prediction. Our models, Perturbation Variational Autoencoder and its semi-supervised extension, Drug Response Variational…

Machine Learning · Statistics 2017-07-07 Ladislav Rampasek , Daniel Hidru , Petr Smirnov , Benjamin Haibe-Kains , Anna Goldenberg

Deep learning has significantly advanced and accelerated de novo molecular generation. Generative networks, namely Variational Autoencoders (VAEs) can not only randomly generate new molecules, but also alter molecular structures to optimize…

Biomolecules · Quantitative Biology 2022-05-04 Ryan J Richards , Austen M Groener

Recently, molecule generation using deep learning has been actively investigated in drug discovery. In this field, Transformer and VAE are widely used as powerful models, but they are rarely used in combination due to structural and…

Biomolecules · Quantitative Biology 2024-04-08 Yasuhiro Yoshikai , Tadahaya Mizuno , Shumpei Nemoto , Hiroyuki Kusuhara

Video Variational Autoencoder (VAE) enables latent video generative modeling by mapping the visual world into compact spatiotemporal latent spaces, improving training efficiency and stability. While existing video VAEs achieve commendable…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Yian Zhao , Feng Wang , Qiushan Guo , Chang Liu , Xiangyang Ji , Jian Zhang , Jie Chen

Imitation learning is an intuitive approach for teaching motion to robotic systems. Although previous studies have proposed various methods to model demonstrated movement primitives, one of the limitations of existing methods is that the…

Robotics · Computer Science 2020-09-24 Takayuki Osa , Shuhei Ikemoto

Recent work in synthetic data generation in the time-series domain has focused on the use of Generative Adversarial Networks. We propose a novel architecture for synthetically generating time-series data with the use of Variational…

Machine Learning · Computer Science 2021-12-08 Abhyuday Desai , Cynthia Freeman , Zuhui Wang , Ian Beaver

Purpose: Handling heterogeneous and mixed data types has become increasingly critical with the exponential growth in real-world databases. While deep generative models attempt to merge diverse data views into a common latent space, they…

Machine Learning · Computer Science 2024-10-23 Alejandro Guerrero-López , Carlos Sevilla-Salcedo , Vanessa Gómez-Verdejo , Pablo M. Olmos

Variational Auto-Encoder (VAE) has been widely applied as a fundamental generative model in machine learning. For complex samples like imagery objects or scenes, however, VAE suffers from the dimensional dilemma between reconstruction…

Machine Learning · Computer Science 2020-02-18 Deli Zhao , Jiapeng Zhu , Bo Zhang

Deep generative models have been praised for their ability to learn smooth latent representation of images, text, and audio, which can then be used to generate new, plausible data. However, current generative models are unable to work with…

Machine Learning · Computer Science 2019-09-09 Bidisha Samanta , Abir De , Gourhari Jana , Pratim Kumar Chattaraj , Niloy Ganguly , Manuel Gomez-Rodriguez

Latent variable models such as the Variational Auto-Encoder (VAE) have become a go-to tool for analyzing biological data, especially in the field of single-cell genomics. One remaining challenge is the interpretability of latent variables…

Genomics · Quantitative Biology 2023-02-20 Romain Lopez , Nataša Tagasovska , Stephen Ra , Kyunghyn Cho , Jonathan K. Pritchard , Aviv Regev

In this paper, we investigate the problem of string-based molecular generation via variational autoencoders (VAEs) that have served a popular generative approach for various tasks in artificial intelligence. We propose a simple, yet…

Machine Learning · Computer Science 2022-08-24 Kisoo Kwon , Kuhwan Jung , Junghyun Park , Hwidong Na , Jinwoo Shin

The key idea of variational auto-encoders (VAEs) resembles that of traditional auto-encoder models in which spatial information is supposed to be explicitly encoded in the latent space. However, the latent variables in VAEs are vectors,…

Machine Learning · Computer Science 2019-01-23 Zhengyang Wang , Hao Yuan , Shuiwang Ji

We develop a machine learning model based on a structured variational autoencoder (VAE) framework to reconstruct and generate neutron star (NS) equations of state (EOS). The VAE consists of an encoder network that maps high-dimensional EOS…

High Energy Astrophysical Phenomena · Physics 2026-01-30 Alex Ross , Tianqi Zhao , Sanjay Reddy
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