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The problem of reliability of the dynamics in biological regulatory networks is studied in the framework of a generalized Boolean network model with continuous timing and noise. Using well-known artificial genetic networks such as the…

Molecular Networks · Quantitative Biology 2008-05-28 Stefan Braunewell , Stefan Bornholdt

This paper is concerned with robust instability analysis of linear feedback systems subject to a dynamic uncertainty. The work is motivated by, and provides a basic foundation for, a more challenging problem of analyzing persistence of…

Systems and Control · Electrical Eng. & Systems 2021-01-28 Shinji Hara , Tetsuya Iwasaki , Yutaka Hori

Control of the living cell functions with remarkable reliability despite the stochastic nature of the underlying molecular networks -- a property presumably optimized by biological evolution. We here ask to what extent the property of a…

Molecular Networks · Quantitative Biology 2009-11-13 Stefan Braunewell , Stefan Bornholdt

This article introduces the problem of robust event disturbance rejection. Inspired by the design principle of linear output regulation, a control structure based on excitable systems is proposed. Unlike the linear case, contraction of the…

Systems and Control · Electrical Eng. & Systems 2025-11-26 Alessandro Cecconi , Michelangelo Bin , Rodolphe Sepulchre , Lorenzo Marconi

This chapter revisits the concept of excitability, a basic system property of neurons. The focus is on excitable systems regarded as behaviors rather than dynamical systems. By this we mean open systems modulated by specific interconnection…

Neurons and Cognition · Quantitative Biology 2017-04-18 Rodolphe Sepulchre , Guillaume Drion , Alessio Franci

Being an example for a relaxation oscillator, the FitzHugh-Nagumo model has been widely employed for describing the generation of action potentials. In this paper, we begin with a biological interpretation of what the subsequent…

Numerical Analysis · Mathematics 2025-01-31 Burcu Gürbüz , Aytül Gökçe , Mahmut Modanlı

Network controllability robustness reflects how well a networked system can maintain its controllability against destructive attacks. Its measure is quantified by a sequence of values that record the remaining controllability of the network…

Physics and Society · Physics 2022-10-14 Yang Lou , Yaodong He , Lin Wang , Kim Fung Tsang , Guanrong Chen

An electronic circuit device, inspired on the FitzHugh-Nagumo model of neuronal excitability, was constructed and shown to operate with characteristics compatible with those of biological sensory neurons. The nonlinear dynamical model of…

The stability of complex networks, from power grids to biological systems, is crucial for their proper functioning. It is thus important to control such systems to maintain or restore their stability. Traditional approaches rely on…

Optimization and Control · Mathematics 2025-09-23 Yuzhen Qin , Fabio Pasqualetti , Danielle S. Bassett , Marcel van Gerven

Various functions of a network of excitable units can be enhanced if the network is in the `critical regime', where excitations are, on average, neither damped nor amplified. An important question is how can such networks self-organize to…

Disordered Systems and Neural Networks · Physics 2020-02-19 Yogesh S. Virkar , Juan G. Restrepo , Woodrow L. Shew , Edward Ott

Neural networks have become increasingly popular in controller design due to their versatility and efficiency. However, their integration into feedback systems can pose stability challenges, particularly in the presence of uncertainties.…

Optimization and Control · Mathematics 2025-03-04 Yuhao Zhang , Xiangru Xu

Feedback-based online optimization algorithms have gained traction in recent years because of their simple implementation, their ability to reject disturbances in real time, and their increased robustness to model mismatch. While the…

Optimization and Control · Mathematics 2019-05-20 Marcello Colombino , John W. Simpson-Porco , Andrey Bernstein

Stability of recurrent models is closely linked with trainability, generalizability and in some applications, safety. Methods that train stable recurrent neural networks, however, do so at a significant cost to expressibility. We propose an…

Machine Learning · Computer Science 2019-12-24 Max Revay , Ian R. Manchester

Network controllability measures how well a networked system can be controlled to a target state, and its robustness reflects how well the system can maintain the controllability against malicious attacks by means of node-removals or…

Systems and Control · Electrical Eng. & Systems 2022-06-02 Yang Lou , Yaodong He , Lin Wang , Guanrong Chen

The stability--robustness--resilience--adaptiveness continuum in neuronal processing follows a hierarchical structure that explains interactions and information processing among the different time scales. Interestingly, using "canonical"…

Neurons and Cognition · Quantitative Biology 2024-04-24 Cristian Axenie

This letter concerns the reliability of coupled oscillator networks in response to fluctuating inputs. Reliability means that (following a transient) an input elicits identical responses upon repeated presentations, regardless of the…

Chaotic Dynamics · Physics 2007-05-23 Kevin K. Lin , Eric Shea-Brown , Lai-Sang Young

Robustness is a basic property of any control system. In the context of linear output regulation, it was proved that embedding an internal model of the exogenous signals is necessary and sufficient to achieve tracking of the desired…

Systems and Control · Electrical Eng. & Systems 2021-04-23 Michelangelo Bin , Daniele Astolfi , Lorenzo Marconi

Networks of excitable nodes have recently attracted much attention particularly in regards to neuronal dynamics, where criticality has been argued to be a fundamental property. Refractory behavior, which limits the excitability of neurons…

Disordered Systems and Neural Networks · Physics 2018-10-22 S. Amin Moosavi , Afshin Montakhab , Alireza Valizadeh

We study the reliability of large networks of coupled neural oscillators in response to fluctuating stimuli. Reliability means that a stimulus elicits essentially identical responses upon repeated presentations. We view the problem on two…

Neurons and Cognition · Quantitative Biology 2008-05-23 Kevin K. Lin , Eric Shea-Brown , Lai-Sang Young

In recent years, Neural Networks (NNs) have been employed to control nonlinear systems due to their potential capability in dealing with situations that might be difficult for conventional nonlinear control schemes. However, to the best of…

Optimization and Control · Mathematics 2025-02-04 Anran Li , John P. Swensen , Mehdi Hosseinzadeh
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