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Despite their successes in vision and language, foundation models have stumbled in pathology, revealing low accuracy, instability, and heavy computational demands. These shortcomings stem not from tuning problems but from deeper conceptual…

Artificial Intelligence · Computer Science 2026-04-21 Hamid R. Tizhoosh

While a broad range of techniques have been proposed to tackle distribution shift, the simple baseline of training on an $\textit{undersampled}$ balanced dataset often achieves close to state-of-the-art-accuracy across several popular…

Machine Learning · Computer Science 2023-06-21 Niladri S. Chatterji , Saminul Haque , Tatsunori Hashimoto

Deep learning methodologies have been employed in several different fields, with an outstanding success in image recognition applications, such as material quality control, medical imaging, autonomous driving, etc. Deep learning models rely…

Computer Vision and Pattern Recognition · Computer Science 2022-03-11 Saul Calderon-Ramirez , Shengxiang Yang , David Elizondo

When we use simulation to evaluate the performance of a stochastic system, the simulation often contains input distributions estimated from real-world data; therefore, there is both simulation and input uncertainty in the performance…

Methodology · Statistics 2020-11-10 Wei Xie , Barry L. Nelson , Russell R. Barton

Despite the recent success of domain generalization in medical image segmentation, voxel-wise annotation for all source domains remains a huge burden. Semi-supervised domain generalization has been proposed very recently to combat this…

Computer Vision and Pattern Recognition · Computer Science 2024-08-02 Muyang Qiu , Jian Zhang , Lei Qi , Qian Yu , Yinghuan Shi , Yang Gao

Semi-supervised learning has attracted much attention due to its less dependence on acquiring abundant annotations from experts compared to fully supervised methods, which is especially important for medical image segmentation which…

Computer Vision and Pattern Recognition · Computer Science 2024-10-24 Yichi Zhang , Jin Yang , Yuchen Liu , Yuan Cheng , Yuan Qi

The prevalence of machine learning in biomedical research is rapidly growing, yet the trustworthiness of such research is often overlooked. While some previous works have investigated the ability of adversarial attacks to degrade model…

Machine Learning · Statistics 2023-08-21 Matthew Rosenblatt , Javid Dadashkarimi , Dustin Scheinost

Language modeling on large-scale datasets leads to impressive performance gains on various downstream language tasks. The validation pre-training loss (or perplexity in autoregressive language modeling) is often used as the evaluation…

Machine Learning · Computer Science 2022-10-26 Hong Liu , Sang Michael Xie , Zhiyuan Li , Tengyu Ma

Recent research has generated hope that inference scaling, such as resampling solutions until they pass verifiers like unit tests, could allow weaker models to match stronger ones. Beyond inference, this approach also enables training…

Machine Learning · Computer Science 2026-03-27 Benedikt Stroebl , Sayash Kapoor , Arvind Narayanan

Recently, with the significant developments in deep learning techniques, solving underdetermined inverse problems has become one of the major concerns in the medical imaging domain. Typical examples include undersampled magnetic resonance…

Image and Video Processing · Electrical Eng. & Systems 2020-06-29 Chang Min Hyun , Seong Hyeon Baek , Mingyu Lee , Sung Min Lee , Jin Keun Seo

Deep learning methods for unsupervised registration often rely on objectives that assume a uniform noise level across the spatial domain (e.g. mean-squared error loss), but noise distributions are often heteroscedastic and input-dependent…

Image and Video Processing · Electrical Eng. & Systems 2024-07-19 Xiaoran Zhang , Daniel H. Pak , Shawn S. Ahn , Xiaoxiao Li , Chenyu You , Lawrence H. Staib , Albert J. Sinusas , Alex Wong , James S. Duncan

Machine Learning (ML) algorithms are vital for supporting clinical decision-making in biomedical informatics. However, their predictive performance can vary across demographic groups, often due to the underrepresentation of historically…

Machine Learning · Computer Science 2025-03-04 Ioannis Bilionis , Ricardo C. Berrios , Luis Fernandez-Luque , Carlos Castillo

Supervised learning has proved effective for medical image analysis. However, it can utilize only the small labeled portion of data; it fails to leverage the large amounts of unlabeled data that is often available in medical image datasets.…

Computer Vision and Pattern Recognition · Computer Science 2020-04-28 Gaurav Fotedar , Nima Tajbakhsh , Shilpa Ananth , Xiaowei Ding

Deep learning techniques have revolutionised medical imaging, improving diagnostic accuracy and enabling both more accurate and earlier disease detection. However, the relationship between pre-training strategies and downstream performance…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Felix Krones

Training datasets for machine learning often have some form of missingness. For example, to learn a model for deciding whom to give a loan, the available training data includes individuals who were given a loan in the past, but not those…

Machine Learning · Computer Science 2020-12-22 Naman Goel , Alfonso Amayuelas , Amit Deshpande , Amit Sharma

Over-parameterized deep models usually over-fit to a given training distribution, which makes them sensitive to small changes and out-of-distribution samples at inference time, leading to low generalization performance. To this end, several…

Computer Vision and Pattern Recognition · Computer Science 2019-12-12 Saeid Asgari Taghanaki , Kumar Abhishek , Ghassan Hamarneh

Existing popular unsupervised embedding learning methods focus on enhancing the instance-level local discrimination of the given unlabeled images by exploring various negative data. However, the existed sample outliers which exhibit large…

Computer Vision and Pattern Recognition · Computer Science 2021-07-20 Jiahuan Zhou , Yansong Tang , Bing Su , Ying Wu

Class imbalance in real-world data poses a common bottleneck for machine learning tasks, since achieving good generalization on under-represented examples is often challenging. Mitigation strategies, such as under or oversampling the data…

Disordered Systems and Neural Networks · Physics 2025-02-03 Emanuele Loffredo , Mauro Pastore , Simona Cocco , Rémi Monasson

Bayesian regression determines model parameters by minimizing the expected loss, an upper bound to the true generalization error. However, the loss ignores misspecification, where models are imperfect. Parameter uncertainties from Bayesian…

Machine Learning · Statistics 2024-11-07 Thomas D Swinburne , Danny Perez
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