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This paper tackles a critical bottleneck in Super-Structure-based divide-and-conquer causal discovery: the high computational cost of constructing accurate Super-Structures--particularly when conditional independence (CI) tests are…

Machine Learning · Computer Science 2026-02-05 Wenyu Wang , Yaping Wan

Learning causality from observational data has received increasing interest across various scientific fields. However, most existing methods assume the absence of latent confounders and restrict the underlying causal graph to be acyclic,…

Methodology · Statistics 2025-11-18 Wei Jin , Lang Lang , Amanda B. Spence , Leah H. Rubin , Yanxun Xu

Causal structure discovery from observational data is fundamental to the causal understanding of autonomous systems such as medical decision support systems, advertising campaigns and self-driving cars. This is essential to solve well-known…

Causal opacity denotes the difficulty in understanding the "hidden" causal structure underlying the decisions of deep neural network (DNN) models. This leads to the inability to rely on and verify state-of-the-art DNN-based systems,…

In biomedical Subgroup Discovery, practitioners are interested in discovering interpretable and homogeneous subgroups within a group of patients. In this paper, assuming that healthy subjects (i.e., controls) share common but irrelevant…

Machine Learning · Computer Science 2026-05-21 Robin Louiset , Edouard Duchesnay , Benoit Dufumier , Antoine Grigis , Pietro Gori

Causal disentanglement aims to learn about latent causal factors behind data, holding the promise to augment existing representation learning methods in terms of interpretability and extrapolation. Recent advances establish identifiability…

Machine Learning · Computer Science 2024-12-25 Ryan Welch , Jiaqi Zhang , Caroline Uhler

The data drawn from biological, economic, and social systems are often confounded due to the presence of unmeasured variables. Prior work in causal discovery has focused on discrete search procedures for selecting acyclic directed mixed…

Machine Learning · Computer Science 2021-02-26 Rohit Bhattacharya , Tushar Nagarajan , Daniel Malinsky , Ilya Shpitser

Accurate trajectory prediction has long been a major challenge for autonomous driving (AD). Traditional data-driven models predominantly rely on statistical correlations, often overlooking the causal relationships that govern traffic…

Artificial Intelligence · Computer Science 2025-05-13 Bonan Wang , Haicheng Liao , Chengyue Wang , Bin Rao , Yanchen Guan , Guyang Yu , Jiaxun Zhang , Songning Lai , Chengzhong Xu , Zhenning Li

Modern cyber-physical systems (CPS) integrate physics, computation, and learning, demanding modeling frameworks that are simultaneously composable, learnable, and verifiable. Yet existing approaches treat these goals in isolation: causal…

Systems and Control · Electrical Eng. & Systems 2026-02-10 Thomas Beckers , Ján Drgoňa , Truong X. Nghiem

Deep learning vulnerability detection has shown promising results in recent years. However, an important challenge that still blocks it from being very useful in practice is that the model is not robust under perturbation and it cannot…

Software Engineering · Computer Science 2024-01-17 Md Mahbubur Rahman , Ira Ceka , Chengzhi Mao , Saikat Chakraborty , Baishakhi Ray , Wei Le

Currently, the field of structure-based drug design is dominated by three main types of algorithms: search-based algorithms, deep generative models, and reinforcement learning. While existing works have typically focused on comparing models…

Machine Learning · Computer Science 2026-01-22 Kangyu Zheng , Kai Zhang , Jiale Tan , Xuehan Chen , Yingzhou Lu , Zaixi Zhang , Lichao Sun , Marinka Zitnik , Tianfan Fu , Zhiding Liang

Drug combinations are essential in cancer therapy, leveraging synergistic drug-drug interactions (DDI) to enhance efficacy and combat resistance. However, the vast combinatorial space makes experimental screening impractical, and existing…

Machine Learning · Computer Science 2026-03-26 Yuxuan Nie , Yutong Song , Jinjie Yang , Yupeng Song , Yujue Zhou , Hong Peng

Causal inference permits us to discover covert relationships of various variables in time series. However, in most existing works, the variables mentioned above are the dimensions. The causality between dimensions could be cursory, which…

Machine Learning · Computer Science 2023-09-14 Yuanhao Liu , Dehui Du , Zihan Jiang , Anyan Huang , Yiyang Li

Medication recommendation is an essential task of AI for healthcare. Existing works focused on recommending drug combinations for patients with complex health conditions solely based on their electronic health records. Thus, they have the…

Machine Learning · Computer Science 2022-07-20 Chaoqi Yang , Cao Xiao , Fenglong Ma , Lucas Glass , Jimeng Sun

With the growing complexity of cyberattacks targeting critical infrastructures such as water treatment networks, there is a pressing need for robust anomaly detection strategies that account for both system vulnerabilities and evolving…

Machine Learning · Computer Science 2025-08-14 Arun Vignesh Malarkkan , Haoyue Bai , Dongjie Wang , Yanjie Fu

Counterfactual medical image generation effectively addresses data scarcity and enhances the interpretability of medical images. However, due to the complex and diverse pathological features of medical images and the imbalanced class…

Computer Vision and Pattern Recognition · Computer Science 2025-04-25 Weizhi Nie , Zichun Zhang , Weijie Wang , Bruno Lepri , Anan Liu , Nicu Sebe

Causal reasoning is a crucial part of science and human intelligence. In order to discover causal relationships from data, we need structure discovery methods. We provide a review of background theory and a survey of methods for structure…

Machine Learning · Computer Science 2021-03-05 Matthew J. Vowels , Necati Cihan Camgoz , Richard Bowden

Unsupervised semantic segmentation aims to achieve high-quality semantic grouping without human-labeled annotations. With the advent of self-supervised pre-training, various frameworks utilize the pre-trained features to train prediction…

Computer Vision and Pattern Recognition · Computer Science 2026-05-11 Junho Kim , Byung-Kwan Lee , Yong Man Ro

Causal inference is a fundamental research topic for discovering the cause-effect relationships in many disciplines. However, not all algorithms are equally well-suited for a given dataset. For instance, some approaches may only be able to…

Machine Learning · Computer Science 2024-03-11 Zhipeng Ma , Marco Kemmerling , Daniel Buschmann , Chrismarie Enslin , Daniel Lütticke , Robert H. Schmitt

Deep neural networks can obtain impressive performance on various tasks under the assumption that their training domain is identical to their target domain. Performance can drop dramatically when this assumption does not hold. One…

Machine Learning · Computer Science 2024-10-10 Gaël Gendron , Michael Witbrock , Gillian Dobbie