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The field of drug discovery hinges on the accurate prediction of binding affinity between prospective drug molecules and target proteins, especially when such proteins directly influence disease progression. However, estimating binding…

We present significant extensions to diffusion-based sequence generation models, blurring the line with autoregressive language models. We introduce hyperschedules, which assign distinct noise schedules to individual token positions,…

Machine Learning · Computer Science 2025-10-08 Nima Fathi , Torsten Scholak , Pierre-André Noël

Breast cancer diagnosis through thermographic image analysis remains a critical challenge in medical AI, with classical deep learning approaches facing limitations in complex thermal pattern classification tasks. This paper presents a novel…

We develop two new estimators for a general class of stationary GARCH models with possibly heavy tailed asymmetrically distributed errors, covering processes with symmetric and asymmetric feedback like GARCH, Asymmetric GARCH, VGARCH and…

Statistics Theory · Mathematics 2015-07-29 Jonathan B. Hill

This work investigates how shallow, NISQ-compatible quantum layers can improve temporal representation learning in real-world sequential data. We develop a QLSTM Seq2Seq autoencoder in which a depth-1 variational quantum circuit is embedded…

Computational Engineering, Finance, and Science · Computer Science 2026-02-13 Tien-Ching Hsieh , Yun-Cheng Tsai , Samuel Yen-Chi Chen

We introduce Equilibrium Matching (EqM), a generative modeling framework built from an equilibrium dynamics perspective. EqM discards the non-equilibrium, time-conditional dynamics in traditional diffusion and flow-based generative models…

Machine Learning · Computer Science 2025-10-14 Runqian Wang , Yilun Du

Reinforcement learning (RL) provides a principled framework for decision-making in partially observable environments, which can be modeled as Markov decision processes and compactly represented through dynamic decision Bayesian networks.…

Quantum Physics · Physics 2025-07-25 Gilberto Cunha , Alexandra Ramôa , André Sequeira , Michael de Oliveira , Luís Barbosa

Continual learning in computer vision faces the critical challenge of catastrophic forgetting, where models struggle to retain prior knowledge while adapting to new tasks. Although recent studies have attempted to leverage the…

Computer Vision and Pattern Recognition · Computer Science 2025-03-25 Xusheng Cao , Haori Lu , Linlan Huang , Fei Yang , Xialei Liu , Ming-Ming Cheng

Several proposals have been recently introduced to implement Quantum Machine Learning (QML) algorithms for the analysis of classical data sets employing variational learning means. There has been, however, a limited amount of work on the…

Quantum Physics · Physics 2022-10-04 Francesco Scala , Stefano Mangini , Chiara Macchiavello , Daniele Bajoni , Dario Gerace

Hybrid variational quantum algorithms are promising for solving practical problems, such as combinatorial optimization, quantum chemistry simulation, quantum machine learning, and quantum error correction on noisy quantum computers.…

We develop a framework for simulating measure-preserving, ergodic dynamical systems on a quantum computer. Our approach provides a new operator-theoretic representation of classical dynamics by combining ergodic theory with quantum…

Accurate prediction of cancer type and primary tumor site is critical for effective diagnosis, personalized treatment, and improved outcomes. Traditional models struggle with the complexity of genomic and clinical data, but quantum…

Quantitative Methods · Quantitative Biology 2025-06-30 Don Roosan , Rubayat Khan , Md Rahatul Ashakin , Tiffany Khou , Saif Nirzhor , Mohammad Rifat Haider

Producing probabilistic forecasts for large collections of similar and/or dependent time series is a practically relevant and challenging task. Classical time series models fail to capture complex patterns in the data, and multivariate…

Machine Learning · Statistics 2019-05-30 Yuyang Wang , Alex Smola , Danielle C. Maddix , Jan Gasthaus , Dean Foster , Tim Januschowski

In the case of Type-2 AGNs, estimating the mass of the black hole is challenging. Understanding how galaxies form and evolve requires considerable insight into the mass of black holes. This work compared different classical and quantum…

Instrumentation and Methods for Astrophysics · Physics 2025-02-25 Sathwik Narkedimilli , Venkata Sriram Amballa , N V Saran Kumar , R Arun Kumar , R Praneeth Reddy , Satvik Raghav , Manish M , Aswath Babu H

Hybrid quantum-classical machine learning offers a promising direction for advancing automated quality control in industrial settings. In this study, we investigate two hybrid quantum-classical approaches for classifying defects in…

Computer Vision and Pattern Recognition · Computer Science 2026-04-01 Akshaya Srinivasan , Xiaoyin Cheng , Jianming Yi , Alexander Geng , Desislava Ivanova , Andreas Weinmann , Ali Moghiseh

Understanding the theoretical capabilities and limitations of quantum machine learning (QML) models to solve machine learning tasks is crucial to advancing both quantum software and hardware developments. Similarly to the classical setting,…

Quantum Physics · Physics 2026-03-31 Qiuhao Chen , Yuling Jiao , Yinan Li , Xiliang Lu , Jerry Zhijian Yang

Electroencephalography (EEG) is widely used in neuroscience and clinical research for analyzing brain activity. While deep learning models such as EEGNet have shown success in decoding EEG signals, they often struggle with data complexity,…

Quantum Physics · Physics 2025-03-05 Chi-Sheng Chen , Samuel Yen-Chi Chen , Huan-Hsin Tseng

Classification using variational quantum circuits is a promising frontier in quantum machine learning. Quantum supervised learning (QSL) applied to classical data using variational quantum circuits involves embedding the data into a quantum…

Quantum Physics · Physics 2026-03-16 Yujin Kim , Changjae Im , Taehyun Kim , Tak Hur , Daniel K. Park

Due to the linearity of quantum mechanics, it remains a challenge to design quantum generative machine learning models that embed non-linear activations into the evolution of the statevector. However, some of the most successful classical…

Quantum Physics · Physics 2023-01-18 Kaitlin Gili , Mykolas Sveistrys , Chris Ballance

We propose a novel QTGNN framework for detecting fraudulent transactions in large-scale financial networks. By integrating quantum embedding, variational graph convolutions, and topological data analysis, QTGNN captures complex transaction…

Machine Learning · Computer Science 2025-12-04 Mohammad Doost , Mohammad Manthouri