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Reliable theoretical predictions of noncovalent interaction energies, which are important e.g. in drug-design and hydrogen-storage applications, belong to longstanding challenges of contemporary quantum chemistry. In this respect, the…

Chemical Physics · Physics 2016-06-06 Matúš Dubecký , René Derian , Petr Jurečka , Lubos Mitas , Pavel Hobza , Michal Otyepka

In the realm of real-world devices, centralized servers in Federated Learning (FL) present challenges including communication bottlenecks and susceptibility to a single point of failure. Additionally, contemporary devices inherently exhibit…

Machine Learning · Computer Science 2024-08-15 Yasser H. Khalil , Amir H. Estiri , Mahdi Beitollahi , Nader Asadi , Sobhan Hemati , Xu Li , Guojun Zhang , Xi Chen

Machine learning force fields (MLFFs) are gradually evolving towards enabling molecular dynamics simulations of molecules and materials with ab initio accuracy but at a small fraction of the computational cost. However, several challenges…

Accurate modeling of the solvent environment for biological molecules is crucial for computational biology and drug design. A popular approach to achieve long simulation time scales for large system sizes is to incorporate the effect of the…

Computational Physics · Physics 2021-08-27 Yaoyi Chen , Andreas Krämer , Nicholas E. Charron , Brooke E. Husic , Cecilia Clementi , Frank Noé

We investigate Machine-Learned Force Fields (MLFFs) trained on approximate Density Functional Theory (DFT) and Coupled Cluster (CC) level potential energy surfaces for the carbon diamond and lithium hydride solids. We assess the accuracy…

We present a complete set of chemo-structural descriptors to significantly extend the applicability of machine-learning (ML) in material screening and mapping energy landscape for multicomponent systems. These new descriptors allow…

Materials Science · Physics 2018-08-08 Kamal Choudhary , Brian DeCost , Francesca Tavazza

Machine Learning (ML)-based force fields are attracting ever-increasing interest due to their capacity to span spatiotemporal scales of classical interatomic potentials at quantum-level accuracy. They can be trained based on high-fidelity…

Chemical Physics · Physics 2024-06-03 Sebastien Röcken , Julija Zavadlav

This paper introduces the Chemical Environment Modeling Theory (CEMT), a novel, generalized framework designed to overcome the limitations inherent in traditional atom-centered Machine Learning Force Field (MLFF) models, widely used in…

Chemical Physics · Physics 2023-10-31 Xiangyun Lei , Weike Ye , Joseph Montoya , Tim Mueller , Linda Hung , Jens Hummelshoej

Data-Free Meta-Learning (DFML) aims to derive knowledge from a collection of pre-trained models without accessing their original data, enabling the rapid adaptation to new unseen tasks. Current methods often overlook the heterogeneity among…

Machine Learning · Computer Science 2024-12-10 Yongxian Wei , Zixuan Hu , Li Shen , Zhenyi Wang , Yu Li , Chun Yuan , Dacheng Tao

This article presents a new force model for performing quantitative simulations of dense granular materials. Interactions between multiple contacts (MC) on the same grain are explicitly taken into account. Our readily applicable method…

Soft Condensed Matter · Physics 2018-10-22 Nicolas Brodu , Joshua A. Dijksman , Robert P. Behringer

Two-dimensional transition metal dichalcogenides (TMDs) exhibit remarkable thermal anisotropy due to their strong intralayer covalent bonding and weak interlayer van der Waals (vdW) interactions. However, accurately modeling their thermal…

Computational Physics · Physics 2025-05-02 Wenwu Jiang , Hekai Bu , Ting Liang , Penghua Ying , Zheyong Fan , Jianbin Xu , Wengen Ouyang

Dynamics of flexible molecules are often determined by an interplay between local chemical bond fluctuations and conformational changes driven by long-range electrostatics and van der Waals interactions. This interplay between interactions…

Chemical Physics · Physics 2021-03-05 Valentin Vassilev-Galindo , Gregory Fonseca , Igor Poltavsky , Alexandre Tkatchenko

An Undirected Weighted Network (UWN) is frequently encountered in a big-data-related application concerning the complex interactions among numerous nodes, e.g., a protein interaction network from a bioinformatics application. A Symmetric…

Machine Learning · Computer Science 2023-06-08 Yurong Zhong , Zhe Xie , Weiling Li , Xin Luo

This paper presents a learning-based framework for approximating an exact magnetic-field interaction model, supported by both numerical and experimental validation. High-fidelity magnetic-field interaction modeling is essential for…

Robotics · Computer Science 2026-04-24 Yuta Takahashi , Hayate Tajima , Shin-ichiro Sakai

To accurately study chemical reactions in the condensed phase or within enzymes, both a quantum-mechanical description and sufficient configurational sampling is required to reach converged estimates. Here, quantum mechanics/molecular…

Chemical Physics · Physics 2022-10-05 Albert Hofstetter , Lennard Böselt , Sereina Riniker

Decentralized Multi-agent Learning (DML) enables collaborative model training while preserving data privacy. However, inherent heterogeneity in agents' resources (computation, communication, and task size) may lead to substantial variations…

Machine Learning · Computer Science 2024-10-22 Seyed Mahmoud Sajjadi Mohammadabadi , Lei Yang , Feng Yan , Junshan Zhang

Molecular dynamics (MD) simulation techniques are widely used for various natural science applications. Increasingly, machine learning (ML) force field (FF) models begin to replace ab-initio simulations by predicting forces directly from…

Computational Physics · Physics 2023-08-29 Xiang Fu , Zhenghao Wu , Wujie Wang , Tian Xie , Sinan Keten , Rafael Gomez-Bombarelli , Tommi Jaakkola

Electronic structure methods offer in principle accurate predictions of molecular properties, however, their applicability is limited by computational costs. Empirical methods are cheaper, but come with inherent approximations and are…

Chemical Physics · Physics 2023-11-16 Moritz Thürlemann , Sereina Riniker

Van der Waals (vdW) interactions are essential for describing molecules and materials, from drug design and catalysis to battery applications. These omnipresent interactions must also be accurately included in machine-learned force fields.…

Chemical Physics · Physics 2026-02-26 Evgeny Moerman , Adil Kabylda , Almaz Khabibrakhmanov , Alexandre Tkatchenko

Continuum manipulators (CMs) are widely used in minimally invasive procedures due to their compliant structure and ability to navigate deep and confined anatomical environments. However, their distributed deformation makes force sensing,…

Robotics · Computer Science 2026-03-16 Mobina Tavangarifard , Jonathan S. Kacines , Qiyu Li , Farshid Alambeigi