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Multi-regional clinical trials (MRCTs) are central to global drug development, enabling evaluation of treatment effects across diverse populations. A key challenge is valid and efficient inference for a region-specific estimand when the…

Methodology · Statistics 2026-02-04 Chenxi Li , Ke Zhu , Shu Yang , Xiaofei Wang

In real-world scenarios, multi-view multi-label learning often encounters the challenge of incomplete training data due to limitations in data collection and unreliable annotation processes. The absence of multi-view features impairs the…

Computer Vision and Pattern Recognition · Computer Science 2025-03-25 Lian Zhao , Jie Wen , Xiaohuan Lu , Wai Keung Wong , Jiang Long , Wulin Xie

Few-shot text classification has recently been promoted by the meta-learning paradigm which aims to identify target classes with knowledge transferred from source classes with sets of small tasks named episodes. Despite their success,…

Computation and Language · Computer Science 2023-05-17 Junfan Chen , Richong Zhang , Yongyi Mao , Jie Xu

Explainable ML for molecular toxicity prediction is a promising approach for efficient drug development and chemical safety. A predictive ML model of toxicity can reduce experimental cost and time while mitigating ethical concerns by…

Quantitative Methods · Quantitative Biology 2022-04-15 Bhanushee Sharma , Vijil Chenthamarakshan , Amit Dhurandhar , Shiranee Pereira , James A. Hendler , Jonathan S. Dordick , Payel Das

Randomized clinical trials typically aim to estimate a marginal treatment effect. While covariate adjustment can improve precision, it may change the estimand in nonlinear models due to noncollapsibility, leading to conditional rather than…

Methodology · Statistics 2026-05-25 Leticia Wuethrich , Torsten Hothorn

Class imbalance has emerged as one of the major challenges for medical image segmentation. The model cascade (MC) strategy significantly alleviates the class imbalance issue via running a set of individual deep models for coarse-to-fine…

Computer Vision and Pattern Recognition · Computer Science 2020-04-22 Chenhong Zhou , Changxing Ding , Xinchao Wang , Zhentai Lu , Dacheng Tao

We consider the problem of estimating the effects of a binary treatment on a continuous outcome of interest from observational data in the absence of confounding by unmeasured factors. We provide a new estimator of the population average…

Methodology · Statistics 2020-08-04 James Robins , Mariela Sued , Quanhong Lei-Gomez , Andrea Rotnitzky

Cross-modality recognition has many important applications in science, law enforcement and entertainment. Popular methods to bridge the modality gap include reducing the distributional differences of representations of different modalities,…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Xin Niu , Enyi Li , Jinchao Liu , Yan Wang , Margarita Osadchy , Yongchun Fang

A central goal of modern causal inference is estimating heterogeneous treatment effects to answer questions like "how does an intervention affect each unit," rather than only on average. We study this problem with panel-data where we…

Machine Learning · Statistics 2026-05-29 Anay Mehrotra , Phuc Tran , Van H. Vu , Manolis Zampetakis

Explainability in time series forecasting is essential for improving model transparency and supporting informed decision-making. In this work, we present CrossScaleNet, an innovative architecture that combines a patch-based cross-attention…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Ibrahim Delibasoglu , Fredrik Heintz

Estimating the individuals' potential response to varying treatment doses is crucial for decision-making in areas such as precision medicine and management science. Most recent studies predict counterfactual outcomes by learning a covariate…

Machine Learning · Computer Science 2024-03-22 Minqin Zhu , Anpeng Wu , Haoxuan Li , Ruoxuan Xiong , Bo Li , Xiaoqing Yang , Xuan Qin , Peng Zhen , Jiecheng Guo , Fei Wu , Kun Kuang

Convergent Cross Mapping (CCM) is a powerful method for detecting causality in coupled nonlinear dynamical systems, providing a model-free approach to capture dynamic causal interactions. Partial Cross Mapping (PCM) was introduced as an…

Machine Learning · Computer Science 2025-02-07 Elise Zhang , François Mirallès , Raphaël Rousseau-Rizzi , Arnaud Zinflou , Di Wu , Benoit Boulet

This paper develops new methods for causal inference in observational studies on a single large network of interconnected units, addressing two key challenges: long-range dependence among units and the presence of general interference. We…

Methodology · Statistics 2025-11-24 Jizhou Liu , Dake Zhang , Eric J. Tchetgen Tchetgen

Extreme multi-label text classification (XMTC) addresses the problem of tagging each text with the most relevant labels from an extreme-scale label set. Traditional methods use bag-of-words (BOW) representations without context information…

Information Retrieval · Computer Science 2019-04-30 Ronghui You , Zihan Zhang , Suyang Dai , Shanfeng Zhu

Understanding how large-scale functional brain networks reorganize during cognitive decline remains a central challenge in neuroimaging. While recent self-supervised models have shown promise for learning representations from resting-state…

Machine Learning · Computer Science 2026-03-03 Karanpartap Singh , Adam Turnbull , Mohammad Abbasi , Kilian Pohl , Feng Vankee Lin , Ehsan Adeli

Estimating heterogeneous treatment effects with machine learning has attracted substantial attention in both academic research and industrial practice. However, the two communities often evaluate models under markedly different conditions.…

Machine Learning · Computer Science 2026-05-26 George Panagopoulos

In this paper, we introduce a unified estimator to analyze various treatment effects in causal inference, including but not limited to the average treatment effect (ATE) and the quantile treatment effect (QTE). The proposed estimator is…

Methodology · Statistics 2025-03-31 Kuan-Hsun Wu , Li-Pang Chen

Multi-Regional Clinical Trials (MRCTs) play a central role in the development of new therapies by enabling the simultaneous evaluation of drug efficacy and safety across diverse global populations. Assessing the consistency of treatment…

Applications · Statistics 2026-02-10 Kunhai Qing , Xinru Ren , Jin Xu , Menggang Yu

Traditional causal inference approaches leverage observational study data to estimate the difference in observed and unobserved outcomes for a potential treatment, known as the Conditional Average Treatment Effect (CATE). However, CATE…

Machine Learning · Statistics 2022-09-22 Tianhui Zhou , William E Carson , David Carlson

Accurate breast lesion risk estimation can significantly reduce unnecessary biopsies and help doctors decide optimal treatment plans. Most existing computer-aided systems rely solely on mammogram features to classify breast lesions. While…

Image and Video Processing · Electrical Eng. & Systems 2021-08-24 Hung Q. Vo , Pengyu Yuan , Tiancheng He , Stephen T. C. Wong , Hien V. Nguyen