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Mapper, a topological algorithm, is frequently used as an exploratory tool to build a graphical representation of data. This representation can help to gain a better understanding of the intrinsic shape of high-dimensional genomic data and…

Genomics · Quantitative Biology 2023-07-19 Erik J. Amézquita , Farzana Nasrin , Kathleen M. Storey , Masato Yoshizawa

Advancing artificial intelligence for physical sciences requires representations that are both interpretable and compatible with the underlying laws of nature. We introduce METASTRINGS, a symbolic language for photonics that expresses…

Solving large-scale Generalized Eigenvalue Problems (GEPs) is a fundamental yet computationally prohibitive task in science and engineering. As a promising direction, contour integral (CI) methods, such as the CIRR algorithm, offer an…

Machine Learning · Computer Science 2025-11-05 Yeqiu Chen , Ziyan Liu , Hong Wang

Large language models (LLMs) have shown that generative pretraining can distill vast world knowledge into compact token representations. While LLMs encapsulate extensive world knowledge, they remain limited in modeling the behavioral…

Machine Learning · Computer Science 2026-03-31 Guilin Li , Yun Zhang , Xiuyuan Chen , Chengqi Li , Bo Wang , Linghe Kong , Wenjia Wang , Weiran Huang , Matthias Hwai Yong Tan

The analysis of events in dynamic environments poses a fundamental challenge in the development of intelligent agents and robots capable of interacting with humans. Current approaches predominantly utilize visual models. However, these…

Computer Vision and Pattern Recognition · Computer Science 2025-05-07 Sergey Linok , Vadim Semenov , Anastasia Trunova , Oleg Bulichev , Dmitry Yudin

Code generation aims to automatically generate code snippets that meet given natural language requirements and plays an important role in software development. Although Code LLMs have shown excellent performance in this domain, their long…

Software Engineering · Computer Science 2024-07-30 Lianghong Guo , Yanlin Wang , Ensheng Shi , Wanjun Zhong , Hongyu Zhang , Jiachi Chen , Ruikai Zhang , Yuchi Ma , Zibin Zheng

Token merging can effectively accelerate various vision systems by processing groups of similar tokens only once and sharing the results across them. However, existing token grouping methods are often ad hoc and random, disregarding the…

Computer Vision and Pattern Recognition · Computer Science 2025-04-28 Haoyu Wu , Jingyi Xu , Hieu Le , Dimitris Samaras

Accurate and efficient brain tumor segmentation remains a critical challenge in neuroimaging due to the heterogeneous nature of tumor subregions and the high computational cost of volumetric inference. In this paper, we propose…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Fatemeh Ziaeetabar

Machine learning solutions are very popular in the field of chemoinformatics, where they have numerous applications, such as novel drug discovery or molecular property prediction. Molecular fingerprints are algorithms commonly used for…

Quantitative Methods · Quantitative Biology 2024-04-01 Michał Szafarczyk , Piotr Ludynia , Przemysław Kukla

Medical imaging plays a vital role in modern diagnostics; however, interpreting high-resolution radiological data remains time-consuming and susceptible to variability among clinicians. Traditional image processing techniques often lack the…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Melika Filvantorkaman , Maral Filvan Torkaman

The definition of a concise and effective testbed for Genetic Programming (GP) is a recurrent matter in the research community. This paper takes a new step in this direction, proposing a different approach to measure the quality of the…

Neural and Evolutionary Computing · Computer Science 2018-05-29 Luiz Otavio Vilas Boas Oliveira , Joao Francisco Barreto da Silva Martins , Luis Fernando Miranda , Gisele Lobo Pappa

Identification of functional elements of a genome often requires dividing a sequence of measurements along a genome into segments differing from adjacent segments. In many applications, the mean of the measured values at multiple genomic…

Applications · Statistics 2015-06-30 S. B. Girimurugan , Jonathan Dennis , Jinfeng Zhang

DNA language models have advanced genomics, but their downstream performance varies widely due to differences in tokenization, pretraining data, and architecture. We argue that a major bottleneck lies in tokenizing sparse and unevenly…

Genomics · Quantitative Biology 2025-12-23 Xiaoxiao Zhou , Zihan Wang , Jingbo Shang , Yang E. Li

Recent advancements in large language models(LLMs), such as GPT-4 and GPT-4o, have shown exceptional performance, especially in languages with abundant resources like English, thanks to extensive datasets that ensure robust training.…

Computation and Language · Computer Science 2024-11-15 Jin Yang , Zhiqiang Wang , Yanbin Lin , Zunduo Zhao

Existing curriculum learning approaches to Neural Machine Translation (NMT) require sampling sufficient amounts of "easy" samples from training data at the early training stage. This is not always achievable for low-resource languages where…

Computation and Language · Computer Science 2021-03-23 Chen Liang , Haoming Jiang , Xiaodong Liu , Pengcheng He , Weizhu Chen , Jianfeng Gao , Tuo Zhao

Spatial Transcriptomics (ST) offers spatially resolved gene expression but remains costly. Predicting expression directly from widely available Hematoxylin and Eosin (H&E) stained images presents a cost-effective alternative. However, most…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Jiarui Ouyang , Yihui Wang , Yihang Gao , Yingxue Xu , Shu Yang , Hao Chen

In standard generative deep learning models, such as autoencoders or GANs, the size of the parameter set is proportional to the complexity of the generated data distribution. A significant challenge is to deploy resource-hungry deep…

Machine Learning · Computer Science 2021-10-29 Shreshth Tuli , Shikhar Tuli , Giuliano Casale , Nicholas R. Jennings

The Mapper algorithm is an essential tool for visualizing complex, high dimensional data in topology data analysis (TDA) and has been widely used in biomedical research. It outputs a combinatorial graph whose structure implies the shape of…

Machine Learning · Computer Science 2025-04-24 Yuyang Tao , Shufei Ge

Machine Speech Chain, simulating the human perception-production loop, proves effective in jointly improving ASR and TTS. We propose TokenChain, a fully discrete speech chain coupling semantic-token ASR with a two-stage TTS: an…

Audio and Speech Processing · Electrical Eng. & Systems 2026-05-05 Mingxuan Wang , Satoshi Nakamura

While language models are increasingly utilized in materials science, typical models rely on frequency-centric tokenization methods originally developed for natural language processing. However, these methods frequently produce excessive…

Computation and Language · Computer Science 2025-06-16 Yerim Oh , Jun-Hyung Park , Junho Kim , SungHo Kim , SangKeun Lee
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