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Both medical care and observational studies in oncology require a thorough understanding of a patient's disease progression and treatment history, often elaborately documented in clinical notes. Despite their vital role, no current oncology…

Computation and Language · Computer Science 2024-03-18 Madhumita Sushil , Vanessa E. Kennedy , Divneet Mandair , Brenda Y. Miao , Travis Zack , Atul J. Butte

Recent advances in natural language processing (NLP) owe their success to pre-training language models on large amounts of unstructured data. Still, there is an increasing effort to combine the unstructured nature of LMs with structured…

Computation and Language · Computer Science 2023-12-22 Juraj Vladika , Alexander Fichtl , Florian Matthes

Objective: The majority of detailed patient information in real-world data (RWD) is only consistently available in free-text clinical documents. Manual curation is expensive and time-consuming. Developing natural language processing (NLP)…

Knowledge-enhanced pre-trained language models (KEPLMs) leverage relation triples from knowledge graphs (KGs) and integrate these external data sources into language models via self-supervised learning. Previous works treat knowledge…

Computation and Language · Computer Science 2024-06-25 Dongyang Li , Taolin Zhang , Longtao Huang , Chengyu Wang , Xiaofeng He , Hui Xue

The increasing complexity and workload of clinical radiology leads to inevitable oversights and mistakes in their use as diagnostic tools, causing delayed treatments and sometimes life-threatening harm to patients. While large language…

Computation and Language · Computer Science 2025-11-14 Jinge Wu , Zhaolong Wu , Ruizhe Li , Tong Chen , Abul Hasan , Yunsoo Kim , Jason P. Y. Cheung , Teng Zhang , Honghan Wu

Artificial intelligence (AI) is reshaping modern healthcare by advancing disease diagnosis, treatment decision-making, and biomedical research. Among AI technologies, large language models (LLMs) have become especially impactful, enabling…

Artificial Intelligence · Computer Science 2025-11-18 Zhengda Wang , Daqian Shi , Jingyi Zhao , Xiaolei Diao , Xiongfeng Tang , Yanguo Qin

Despite their success at many natural language processing (NLP) tasks, large language models still struggle to effectively leverage knowledge for knowledge-intensive tasks, manifesting limitations such as generating incomplete, non-factual,…

Computation and Language · Computer Science 2024-10-03 Yougang Lyu , Lingyong Yan , Shuaiqiang Wang , Haibo Shi , Dawei Yin , Pengjie Ren , Zhumin Chen , Maarten de Rijke , Zhaochun Ren

Clinical decision-making depends on expert reasoning, which is guided by standardized, evidence-based guidelines. However, translating these guidelines into automated clinical decision support systems risks inaccuracy and importantly, loss…

The extraction of lung lesion information from clinical and medical imaging reports is crucial for research on and clinical care of lung-related diseases. Large language models (LLMs) can be effective at interpreting unstructured text in…

Computation and Language · Computer Science 2024-11-18 Diya Li , Asim Kadav , Aijing Gao , Rui Li , Richard Bourgon

Despite the impressive performance of large language models (LLMs) pretrained on vast knowledge corpora, advancing their knowledge manipulation-the ability to effectively recall, reason, and transfer relevant knowledge-remains challenging.…

Computation and Language · Computer Science 2026-01-13 Qitan Lv , Tianyu Liu , Qiaosheng Zhang , Xingcheng Xu , Chaochao Lu

Large language models (LLMs) are transforming the way information is retrieved with vast amounts of knowledge being summarized and presented via natural language conversations. Yet, LLMs are prone to highlight the most frequently seen…

Computation and Language · Computer Science 2024-02-20 Julien Delile , Srayanta Mukherjee , Anton Van Pamel , Leonid Zhukov

With the rapid advancements in cancer research, the information that is useful for characterizing disease, staging tumors, and creating treatment and survivorship plans has been changing at a pace that creates challenges when physicians try…

Large language models (LLMs) have emerged as transformative tools in medicine, with strong capabilities in language understanding, reasoning, and structured information extraction. Radiation oncology is particularly well suited for LLM…

Large Language Models (LLMs) hold significant promise for improving clinical decision support and reducing physician burnout by synthesizing complex, longitudinal cancer Electronic Health Records (EHRs). However, their implementation in…

Computation and Language · Computer Science 2026-01-12 Dongchen Li , Jitao Liang , Wei Li , Xiaoyu Wang , Longbing Cao , Kun Yu

The integration of Large Language Models (LLMs) into biomedical research offers new opportunities for domainspecific reasoning and knowledge representation. However, their performance depends heavily on the semantic quality of training…

Inductive Knowledge Graph Reasoning (KGR) aims to discover facts in open-domain KGs containing unknown entities and relations, which poses a challenge for KGR models in comprehending uncertain KG components. Existing studies have proposed…

Computation and Language · Computer Science 2026-04-08 Xingrui Zhuo , Jiapu Wang , Gongqing Wu , Zhongyuan Wang , Jichen Zhang , Shirui Pan , Xindong Wu

There is vivid research on adapting Large Language Models (LLMs) to perform a variety of tasks in high-stakes domains such as healthcare. Despite their popularity, there is a lack of understanding of the extent and contributing factors that…

Computation and Language · Computer Science 2024-06-07 Anand Subramanian , Viktor Schlegel , Abhinav Ramesh Kashyap , Thanh-Tung Nguyen , Vijay Prakash Dwivedi , Stefan Winkler

Chemotherapy for cancer treatment is costly and accompanied by severe side effects, highlighting the critical need for early prediction of treatment outcomes to improve patient management and informed decision-making. Predictive models for…

Large Language Models (LLMs) perform well in general QA but often struggle in domain-specific scenarios. Retrieval-Augmented Generation (RAG) introduces external knowledge but suffers from hallucinations and latency due to noisy retrievals.…

Computation and Language · Computer Science 2025-09-19 Bolei He , Xinran He , Run Shao , Shanfu Shu , Xianwei Xue , Mingquan Cheng , Haifeng Li , Zhenhua Ling

Large Language Models (LLMs) have demonstrated remarkable capabilities in many real-world applications. Nonetheless, LLMs are often criticized for their tendency to produce hallucinations, wherein the models fabricate incorrect statements…

Computation and Language · Computer Science 2024-06-05 Qinggang Zhang , Junnan Dong , Hao Chen , Daochen Zha , Zailiang Yu , Xiao Huang