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Hyperspectral images taken from aircraft or satellites contain information from hundreds of spectral bands, within which lie latent lower-dimensional structures that can be exploited for classifying vegetation and other materials. A…

Computer Vision and Pattern Recognition · Computer Science 2023-02-21 Sam L. Polk , Kangning Cui , Aland H. Y. Chan , David A. Coomes , Robert J. Plemmons , James M. Murphy

We propose a graph-based clustering method based on Cluster Catch Digraphs (CCDs) that extends their applicability to moderate-dimensional data settings. Existing CCD variants, such as RK-CCDs, rely on spatial randomness tests based on…

Machine Learning · Computer Science 2026-04-15 Rui Shi , Elvan Ceyhan , Nedret Billor

Graph clustering discovers groups or communities within networks. Deep learning methods such as autoencoders (AE) extract effective clustering and downstream representations but cannot incorporate rich structural information. While Graph…

Machine Learning · Computer Science 2022-04-28 Gayan K. Kulatilleke , Marius Portmann , Shekhar S. Chandra

The single-cell RNA sequencing (scRNA-seq) technology enables researchers to study complex biological systems and diseases with high resolution. The central challenge is synthesizing enough scRNA-seq samples; insufficient samples can impede…

Genomics · Quantitative Biology 2023-12-25 Yixuan Wang , Shuangyin Li , Shimin DI , Lei Chen

Chromatin is a polymer complex of DNA and proteins that regulates gene expression. The three-dimensional structure and organization of chromatin controls DNA transcription and replication. High-throughput chromatin conformation capture…

In this paper, we propose a unified framework for sampling, clustering and embedding data points in semi-metric spaces. For a set of data points $\Omega=\{x_1, x_2, \ldots, x_n\}$ in a semi-metric space, we consider a complete graph with…

Social and Information Networks · Computer Science 2017-08-02 Chia-Tai Chang , Cheng-Shang Chang

We present an unsupervised data processing workflow that is specifically designed to obtain a fast conformational clustering of long molecular dynamics simulation trajectories. In this approach we combine two dimensionality reduction…

Chemical Physics · Physics 2023-08-09 Simon Hunkler , Kay Diederichs , Oleksandra Kukharenko , Christine Peter

Deep clustering (DC) has become the state-of-the-art for unsupervised clustering. In principle, DC represents a variety of unsupervised methods that jointly learn the underlying clusters and the latent representation directly from…

Machine Learning · Computer Science 2020-05-22 Lele Cao , Sahar Asadi , Wenfei Zhu , Christian Schmidli , Michael Sjöberg

Subspace clustering (SC) refers to the problem of clustering high-dimensional data into a union of low-dimensional subspaces. Based on spectral clustering, state-of-the-art approaches solve SC problem within a two-stage framework. In the…

Machine Learning · Computer Science 2019-05-06 Shuai Yang , Wenqi Zhu , Yuesheng Zhu

We introduce a novel self-supervised deep clustering approach tailored for unstructured data without requiring prior knowledge of the number of clusters, termed Adaptive Self-supervised Robust Clustering (ASRC). In particular, ASRC…

Machine Learning · Computer Science 2024-07-31 Chen-Lu Ding , Jiancan Wu , Wei Lin , Shiyang Shen , Xiang Wang , Yancheng Yuan

Clustering, as an unsupervised technique, plays a pivotal role in various data analysis applications. Among clustering algorithms, Spectral Clustering on Euclidean Spaces has been extensively studied. However, with the rapid evolution of…

Machine Learning · Computer Science 2024-12-09 Sagar Ghosh , Swagatam Das

Clustering has long been a popular unsupervised learning approach to identify groups of similar objects and discover patterns from unlabeled data in many applications. Yet, coming up with meaningful interpretations of the estimated clusters…

Methodology · Statistics 2020-05-26 Minjie Wang , Tianyi Yao , Genevera I. Allen

Four-dimensional scanning transmission electron microscopy (4D-STEM) enables mapping of diffraction information with nanometer-scale spatial resolution, offering detailed insight into local structure, orientation, and strain. However, as…

Diffusion models, widely recognized for their success in generative tasks, have not yet been applied to clustering. We introduce Clustering via Diffusion (CLUDI), a self-supervised framework that combines the generative power of diffusion…

Artificial Intelligence · Computer Science 2025-07-31 Roy Uziel , Irit Chelly , Oren Freifeld , Ari Pakman

Semi-supervised clustering is an very important topic in machine learning and computer vision. The key challenge of this problem is how to learn a metric, such that the instances sharing the same label are more likely close to each other on…

Machine Learning · Computer Science 2015-01-27 Gang Chen

Most publicly available datasets for image classification are with single labels, while images are inherently multi-labeled in our daily life. Such an annotation gap makes many pre-trained single-label classification models fail in…

Computer Vision and Pattern Recognition · Computer Science 2022-06-15 Tianze Yu , Jianzhe Lin , Lichao Mou , Yuansheng Hua , Xiaoxiang Zhu , Z. Jane Wang

Estimating single-cell responses across various perturbations facilitates the identification of key genes and enhances drug screening, significantly boosting experimental efficiency. However, single-cell sequencing is a destructive process,…

Machine Learning · Computer Science 2026-04-28 Changxi Chi , Jun Xia , Yufei Huang , Zhuoli Ouyang , Cheng Tan , Yunfan Liu , Jingbo Zhou , Chang Yu , Liangyu Yuan , Siyuan Li , Zelin Zang , Stan Z. Li

Deep clustering methods typically rely on a single, well-defined representation for clustering. In contrast, pretrained diffusion models provide abundant and diverse multi-scale representations across network layers and noise timesteps.…

Machine Learning · Computer Science 2026-01-22 Haidong Hu , Xiaoyu Zheng , Jin Zhou , Yingxu Wang , Rui Wang , Pei Dong , Shiyuan Han , Lin Wang , C. L. Philip Chen , Tong Zhang , Yuehui Chen

Accurate cell type annotation is a crucial step in analyzing single-cell RNA sequencing (scRNA-seq) data, which provides valuable insights into cellular heterogeneity. However, due to the high dimensionality and prevalence of zero elements…

Machine Learning · Computer Science 2025-08-14 Huifa Li , Jie Fu , Xinlin Zhuang , Haolin Yang , Xinpeng Ling , Tong Cheng , Haochen xue , Imran Razzak , Zhili Chen

The scarcity of labeled data often impedes the application of deep learning to the segmentation of medical images. Semi-supervised learning seeks to overcome this limitation by exploiting unlabeled examples in the learning process. In this…

Computer Vision and Pattern Recognition · Computer Science 2021-06-25 Jizong Peng , Marco Pedersoli , Christian Desrosiers