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Minimizing adverse reactions caused by drug-drug interactions has always been a momentous research topic in clinical pharmacology. Detecting all possible interactions through clinical studies before a drug is released to the market is a…

Artificial Intelligence · Computer Science 2018-03-13 Meng Wang

Knowledge graph (KG) enhanced recommendation has demonstrated improved performance in the recommendation system (RecSys) and attracted considerable research interest. Recently the literature has adopted neural graph networks (GNNs) on the…

Information Retrieval · Computer Science 2022-11-15 Liangwei Yang , Shen Wang , Jibing Gong , Shaojie Zheng , Shuying Du , Zhiwei Liu , Philip S. Yu

Knowledge graph (KG) is used to represent data in terms of entities and structural relations between the entities. This representation can be used to solve complex problems such as recommendation systems and question answering. In this…

Artificial Intelligence · Computer Science 2022-12-09 Ajay Kumar Gogineni

Electronic medical records contain multi-format electronic medical data that consist of an abundance of medical knowledge. Facing with patient's symptoms, experienced caregivers make right medical decisions based on their professional…

Databases · Computer Science 2017-07-25 Meng Wang , Jiaheng Zhang , Jun Liu , Wei Hu , Sen Wang , Xue Li , Wenqiang Liu

CDR (Cross-Domain Recommendation), i.e., leveraging information from multiple domains, is a critical solution to data sparsity problem in recommendation system. The majority of previous research either focused on single-target CDR (STCDR)…

Information Retrieval · Computer Science 2024-11-27 Xiaopeng Liu , Juan Zhang , Chongqi Ren , Shenghui Xu , Zhaoming Pan , Zhimin Zhang

It is a long-standing challenge in modern recommender systems to effectively make recommendations for new users, namely the cold-start problem. Cross-Domain Recommendation (CDR) has been proposed to address this challenge, but current ways…

Information Retrieval · Computer Science 2023-10-18 Xin Su , Yao Zhou , Zifei Shan , Qian Chen

Recommender systems (RS) have become crucial tools for information filtering in various real world scenarios. And cross domain recommendation (CDR) has been widely explored in recent years in order to provide better recommendation results…

Information Retrieval · Computer Science 2025-03-19 Hao Zhang , Mingyue Cheng , Qi Liu , Junzhe Jiang , Xianquan Wang , Rujiao Zhang , Chenyi Lei , Enhong Chen

Recent years have witnessed the fast development of the emerging topic of Graph Learning based Recommender Systems (GLRS). GLRS employ advanced graph learning approaches to model users' preferences and intentions as well as items'…

Information Retrieval · Computer Science 2021-05-14 Shoujin Wang , Liang Hu , Yan Wang , Xiangnan He , Quan Z. Sheng , Mehmet A. Orgun , Longbing Cao , Francesco Ricci , Philip S. Yu

Digital libraries provide different access paths, allowing users to explore their collections. For instance, paper recommendation suggests literature similar to some selected paper. Their implementation is often cost-intensive, especially…

Information Retrieval · Computer Science 2024-12-23 Hermann Kroll , Christin K. Kreutz , Bill Matthias Thang , Philipp Schaer , Wolf-Tilo Balke

Adverse drug reactions (ADRs) are a major barrier to safe and effective pharmacotherapy and increasingly reflect higher order interactions between drugs, genetic background, and clinical phenotypes. Existing graph based approaches usually…

Quantitative Methods · Quantitative Biology 2025-12-02 Ze Cai , Haotian Tang , Shuai Gao , Binbin Zhou , Junhan Zhao , Jun Wen

Medication recommendation is a crucial task for intelligent healthcare systems. Previous studies mainly recommend medications with electronic health records (EHRs). However, some details of interactions between doctors and patients may be…

Computation and Language · Computer Science 2022-09-16 Zhenfeng He , Yuqiang Han , Zhenqiu Ouyang , Wei Gao , Hongxu Chen , Guandong Xu , Jian Wu

Interference between pharmacological substances can cause serious medical injuries. Correctly predicting so-called drug-drug interactions (DDI) does not only reduce these cases but can also result in a reduction of drug development cost.…

Machine Learning · Computer Science 2019-08-06 Md. Rezaul Karim , Michael Cochez , Joao Bosco Jares , Mamtaz Uddin , Oya Beyan , Stefan Decker

Accurate and robust drug response prediction is of utmost importance in precision medicine. Although many models have been developed to utilize the representations of drugs and cancer cell lines for predicting cancer drug responses (CDR),…

Quantitative Methods · Quantitative Biology 2023-11-22 Xiaoqiong Xia , Chaoyu Zhu , Yuqi Shan , Fan Zhong , Lei Liu

We present an end-to-end, interpretable, deep-learning architecture to learn a graph kernel that predicts the outcome of chronic disease drug prescription. This is achieved through a deep metric learning collaborative with a Support Vector…

Machine Learning · Computer Science 2020-08-06 Hao-Ren Yao , Der-Chen Chang , Ophir Frieder , Wendy Huang , I-Chia Liang , Chi-Feng Hung

Drug repurposing is more relevant than ever due to drug development's rising costs and the need to respond to emerging diseases quickly. Knowledge graph embedding enables drug repurposing using heterogeneous data sources combined with…

With the advancement in the technology sector spanning over every field, a huge influx of information is inevitable. Among all the opportunities that the advancements in the technology have brought, one of them is to propose efficient…

Information Retrieval · Computer Science 2021-12-14 Sudhanshu , Narinder Singh Punn , Sanjay Kumar Sonbhadra , Sonali Agarwal

Adverse Drug Reaction (ADR) is a significant public health concern world-wide. Numerous graph-based methods have been applied to biomedical graphs for predicting ADRs in pre-marketing phases. ADR detection in post-market surveillance is no…

Machine Learning · Computer Science 2020-04-02 Heeyoung Kwak , Minwoo Lee , Seunghyun Yoon , Jooyoung Chang , Sangmin Park , Kyomin Jung

In the last years, deep learning has shown to be a game-changing technology in artificial intelligence thanks to the numerous successes it reached in diverse application fields. Among others, the use of deep learning for the recommendation…

Information Retrieval · Computer Science 2018-07-16 Vito Bellini , Angelo Schiavone , Tommaso Di Noia , Azzurra Ragone , Eugenio Di Sciascio

Automated medical report generation has demonstrated the potential to significantly reduce the workload associated with time-consuming medical reporting. Recent generative representation learning methods have shown promise in integrating…

Computer Vision and Pattern Recognition · Computer Science 2025-10-31 Shuchang Ye , Mingyuan Meng , Mingjian Li , Dagan Feng , Usman Naseem , Jinman Kim

Drug discovery is a critical task in biomedical natural language processing (NLP), yet explainable drug discovery remains underexplored. Meanwhile, large language models (LLMs) have shown remarkable abilities in natural language…

Computation and Language · Computer Science 2025-02-28 Kai Zhang , Rui Zhu , Shutian Ma , Jingwei Xiong , Yejin Kim , Fabricio Murai , Xiaozhong Liu