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Coarse-grained (CG) molecular dynamics simulations extend the length and time scale of atomistic simulations by replacing groups of correlated atoms with CG beads. Machine-learned coarse-graining (MLCG) has recently emerged as a promising…

Chemical Physics · Physics 2025-06-25 Leon Klein , Atharva Kelkar , Aleksander Durumeric , Yaoyi Chen , Frank Noé

Knowledge distillation has made remarkable achievements in model compression. However, most existing methods require the original training data, which is usually unavailable due to privacy and security issues. In this paper, we propose a…

Computer Vision and Pattern Recognition · Computer Science 2022-08-15 Xinyi Yu , Ling Yan , Yang Yang , Libo Zhou , Linlin Ou

In this paper, we introduce a novel knowledge distillation approach for the semantic segmentation task. Unlike previous methods that rely on power-trained teachers or other modalities to provide additional knowledge, our approach does not…

Computer Vision and Pattern Recognition · Computer Science 2024-07-19 Shoumeng Qiu , Jie Chen , Xinrun Li , Ru Wan , Xiangyang Xue , Jian Pu

Coarse-grained (CG) molecular dynamics enables the study of biological processes at temporal and spatial scales that would be intractable at an atomistic resolution. However, accurately learning a CG force field remains a challenge. In this…

Advances in self-distillation have shown that when knowledge is distilled from a teacher to a student using the same deep learning (DL) architecture, the student performance can surpass the teacher particularly when the network is…

Machine Learning · Computer Science 2025-06-25 Muhammad Haseeb Aslam , Clara Martinez , Marco Pedersoli , Alessandro Koerich , Ali Etemad , Eric Granger

Knowledge distillation between machine learning models has opened many new avenues for parameter count reduction, performance improvements, or amortizing training time when changing architectures between the teacher and student network. In…

Machine Learning · Computer Science 2020-11-24 Jonathan Raiman

The ability of learning from noisy labels is very useful in many visual recognition tasks, as a vast amount of data with noisy labels are relatively easy to obtain. Traditionally, the label noises have been treated as statistical outliers,…

Computer Vision and Pattern Recognition · Computer Science 2017-04-11 Yuncheng Li , Jianchao Yang , Yale Song , Liangliang Cao , Jiebo Luo , Li-Jia Li

Atomistic or ab-initio molecular dynamics simulations are widely used to predict thermodynamics and kinetics and relate them to molecular structure. A common approach to go beyond the time- and length-scales accessible with such…

Machine-learned coarse-grained (MLCG) molecular dynamics is a promising option for modeling biomolecules. However, MLCG models currently require large amounts of data from reference atomistic molecular dynamics or substantial computation…

Biological Physics · Physics 2024-07-02 Aleksander E. P. Durumeric , Yaoyi Chen , Frank Noé , Cecilia Clementi

Knowledge distillation is used, in generative language modeling, to train a smaller student model using the help of a larger teacher model, resulting in improved capabilities for the student model. In this paper, we formulate a more general…

Computation and Language · Computer Science 2025-02-26 Guanlin Liu , Anand Ramachandran , Tanmay Gangwani , Yan Fu , Abhinav Sethy

Machine-learned coarse-grained (CG) models often suffer from noisy training data, limiting their accuracy and transferability. We propose a method to generate low-noise training data based on the potential of mean force by constraining CG…

Computational Physics · Physics 2026-03-03 Zheyong Fan , Wenjun Zhang , Zhenhao Zhang , Ke Xu , Xuecheng Shao , Haikuan Dong

Knowledge distillation compresses a larger neural model (teacher) into smaller, faster student models by training them to match teacher outputs. However, the internal computational transformations that occur during this process remain…

Machine Learning · Computer Science 2026-03-10 Reilly Haskins , Benjamin Adams

Neural network potentials (NNPs) offer a powerful alternative to traditional force fields for molecular dynamics (MD) simulations. Accurate and stable MD simulations, crucial for evaluating material properties, require training data…

Machine Learning · Computer Science 2025-06-23 Naoki Matsumura , Yuta Yoshimoto , Yuto Iwasaki , Meguru Yamazaki , Yasufumi Sakai

Gradient-domain machine learning (GDML) is an accurate and efficient approach to learn a molecular potential and associated force field based on the kernel ridge regression algorithm. Here, we demonstrate its application to learn an…

Computational Physics · Physics 2020-06-24 Jiang Wang , Stefan Chmiela , Klaus-Robert Müller , Frank Noè , Cecilia Clementi

In natural language processing (NLP) tasks, slow inference speed and huge footprints in GPU usage remain the bottleneck of applying pre-trained deep models in production. As a popular method for model compression, knowledge distillation…

Computation and Language · Computer Science 2020-12-15 Fei Yuan , Linjun Shou , Jian Pei , Wutao Lin , Ming Gong , Yan Fu , Daxin Jiang

Iterative generative models, such as noise conditional score networks and denoising diffusion probabilistic models, produce high quality samples by gradually denoising an initial noise vector. However, their denoising process has many…

Machine Learning · Computer Science 2021-01-08 Eric Luhman , Troy Luhman

Machine-learned coarse-grained (CG) models have the potential for simulating large molecular complexes beyond what is possible with atomistic molecular dynamics. However, training accurate CG models remains a challenge. A widely used…

Coarse-grained (CG) models provide an effective route to reducing the complexity of molecular simulations (MD), but conventional approaches depend heavily on long all-atom MD trajectories to adequately sample configurational space. This…

Chemical Physics · Physics 2025-10-28 Maximilian Stupp , P. S. Koutsourelakis

Training deep neural network (DNN) with noisy labels is practically challenging since inaccurate labels severely degrade the generalization ability of DNN. Previous efforts tend to handle part or full data in a unified denoising flow via…

Computer Vision and Pattern Recognition · Computer Science 2022-08-24 Boshen Zhang , Yuxi Li , Yuanpeng Tu , Jinlong Peng , Yabiao Wang , Cunlin Wu , Yang Xiao , Cairong Zhao

Learning with noisy labels has become an effective strategy for enhancing the robustness of models, which enables models to better tolerate inaccurate data. Existing methods either focus on optimizing the loss function to mitigate the…

Artificial Intelligence · Computer Science 2024-06-04 Xiaming Che , Junlin Zhang , Zhuang Qi , Xin Qi
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