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Quantum computers have demonstrated utility in simulating quantum systems beyond brute-force classical approaches. As the community builds on these demonstrations to explore using quantum computing for applied research, algorithms and…

The ongoing convergence of HPC and cloud computing presents a fundamental challenge: HPC applications, designed for static and homogeneous supercomputers, are ill-suited for the dynamic, heterogeneous, and volatile nature of the cloud.…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-03-17 Aditya Bhosale , Advait Tahilyani , Laxmikant Kale , Sara Kokkila-Schumacher

A new class of Second generation high-performance computing applications with heterogeneous, dynamic and data-intensive properties have an extended set of requirements, which cover application deployment, resource allocation, -control, and…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-02-28 Ole Weidner , Malcolm Atkinson , Adam Barker , Rosa Filgueira

Manipulating quantum computing hardware in the presence of imperfect devices and control systems is a central challenge in realizing useful quantum computers. Susceptibility to noise limits the performance and capabilities of noisy…

While Quantum Machine Learning (QML) holds great potential, its practical realization on Noisy Intermediate-Scale Quantum (NISQ) hardware has been hindered by the limitations of variational quantum circuits (VQCs). Recent evidence suggests…

Incorporating Quantum Computers into High Performance Computing (HPC) environments (commonly referred to as HPC+QC integration) marks a pivotal step in advancing computational capabilities for scientific research. Here we report the…

Quantum computing (QC) introduces a novel mode of computation with the possibility of greater computational power that remains to be exploited - presenting exciting opportunities for high performance computing (HPC) applications. However,…

This paper introduces a vision for Quantum Software Development lifecycle, proposing a hybrid full-stack iterative model that integrates quantum and classical computing. Addressing the current challenges in Quantum Computing (QC) such as…

Software Engineering · Computer Science 2025-04-09 Arif Ali Khan , Davide Taibi , Muhammad Azeem Akbar

We present a blueprint for a quantum middle layer that supports applications across various quantum technologies. Inspired by concepts and abstractions from HPC libraries and middleware, our design is backend-neutral and context-aware. A…

Emerging Technologies · Computer Science 2025-10-09 Stefano Markidis , Gilbert Netzer , Luca Pennati , Ivy Peng

To harness the power of quantum computing (QC) in the near future, tight and efficient integration of QC with high performance computing (HPC) infrastructure (both on the software (SW) and the hardware (HW) level) is crucial. This paper…

Emerging Technologies · Computer Science 2024-07-29 Amr Elsharkawy , Xiaorang Guo , Martin Schulz

High-Performance Computing (HPC) systems are the most powerful tools that we currently have to solve complex scientific simulations. Quantum computing (QC) has the potential to enhance HPC systems by accelerating the execution of specific…

We propose an architecture, called NVQLink, for connecting high-performance computing (HPC) resources to the control system of a quantum processing unit (QPU) to accelerate workloads necessary to the operation of the QPU. We aim to support…

Recent advances in quantum computing have brought us closer to realizing the potential of this transformative technology. While significant strides have been made in quantum error correction, many challenges persist, particularly in the…

Quantum Physics · Physics 2025-12-03 Mateusz Meller , Vendel Szeremi , Oliver Thomson Brown

Programming for today's quantum computers is making significant strides toward modern workflows compatible with high performance computing (HPC), but fundamental challenges still remain in the integration of these vastly different…

Quantum information processing holds great promise for pushing beyond the current frontiers in computing. Specifically, quantum computation promises to accelerate the solving of certain problems, and there are many opportunities for…

Quantum Computing (QC) offers significant potential to enhance scientific discovery in fields such as quantum chemistry, optimization, and artificial intelligence. Yet QC faces challenges due to the noisy intermediate-scale quantum era's…

Achieving high-performance computation on quantum systems presents a formidable challenge that necessitates bridging the capabilities between quantum hardware and classical computing resources. This study introduces an innovative…

Quantum Physics · Physics 2024-03-19 Kuan-Cheng Chen , Xiaoren Li , Xiaotian Xu , Yun-Yuan Wang , Chen-Yu Liu

Heterogeneous high-performance computing (HPC) systems offer novel architectures which accelerate specific workloads through judicious use of specialized coprocessors. A promising architectural approach for future scientific computations is…

The prospects of quantum computing have driven efforts to realize fully functional quantum processing units (QPUs). Recent success in developing proof-of-principle QPUs has prompted the question of how to integrate these emerging processors…

Emerging Technologies · Computer Science 2015-12-10 Keith A. Britt , Travis S. Humble

The design of post-quantum cryptography (PQC) hardware is a complex and hierarchical process with many challenges. A primary bottleneck is the conversion of PQC reference codes from C to high-level synthesis (HLS) specifications, which…

Cryptography and Security · Computer Science 2026-03-10 Buddhi Perera , Zeng Wang , Weihua Xiao , Mohammed Nabeel , Ozgur Sinanoglu , Johann Knechtel , Ramesh Karri