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Related papers: MedSAE: Dissecting MedCLIP Representations with Sp…

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We have two main contributions in this work: 1. We explore the usage of a stacked denoising autoencoder, and a paragraph vector model to learn task-independent dense patient representations directly from clinical notes. We evaluate these…

Computation and Language · Computer Science 2017-11-15 Madhumita Sushil , Simon Šuster , Kim Luyckx , Walter Daelemans

Accurate imputation of missing laboratory values in electronic health records (EHRs) is critical to enable robust clinical predictions and reduce biases in AI systems in healthcare. Existing methods, such as XGBoost, softimpute, GAIN,…

Machine Learning · Computer Science 2025-06-27 David Restrepo , Chenwei Wu , Yueran Jia , Jaden K. Sun , Jack Gallifant , Catherine G. Bielick , Yugang Jia , Leo A. Celi

Medical image classification is a critical problem for healthcare, with the potential to alleviate the workload of doctors and facilitate diagnoses of patients. However, two challenges arise when deploying deep learning models to real-world…

Computer Vision and Pattern Recognition · Computer Science 2023-10-06 An Yan , Yu Wang , Yiwu Zhong , Zexue He , Petros Karypis , Zihan Wang , Chengyu Dong , Amilcare Gentili , Chun-Nan Hsu , Jingbo Shang , Julian McAuley

Reliable and interpretable decision-making is essential in medical imaging, where diagnostic outcomes directly influence patient care. Despite advances in deep learning, most medical AI systems operate as opaque black boxes, providing…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Pirzada Suhail , Aditya Anand , Amit Sethi

Sparse autoencoders (SAEs) interpret neural network representations by decomposing activations into sparse combinations of dictionary atoms. However, SAEs assume features combine additively through linear reconstruction, an assumption that…

Machine Learning · Computer Science 2026-05-26 Panagiotis Koromilas , Andreas D. Demou , James Oldfield , Yannis Panagakis , Mihalis Nicolaou

The development of deep learning models in medical image analysis is majorly limited by the lack of large-sized and well-annotated datasets. Unsupervised learning does not require labels and is more suitable for solving medical image…

Computer Vision and Pattern Recognition · Computer Science 2023-01-06 Zi'an Xu , Yin Dai , Fayu Liu , Weibing Chen , Yue Liu , Lifu Shi , Sheng Liu , Yuhang Zhou

Sparse autoencoders (SAEs) are widely used to extract interpretable features from neural network representations, often under the implicit assumption that concepts correspond to independent linear directions. However, a growing body of…

Vision-language pre-training (VLP) models have been demonstrated to be effective in many computer vision applications. In this paper, we consider developing a VLP model in the medical domain for making computer-aided diagnoses (CAD) based…

Computer Vision and Pattern Recognition · Computer Science 2023-05-19 Qiuhui Chen , Xinyue Hu , Zirui Wang , Yi Hong

While sparse autoencoders (SAEs) have generated significant excitement, a series of negative results have added to skepticism about their usefulness. Here, we establish a conceptual distinction that reconciles competing narratives…

Machine Learning · Computer Science 2025-07-01 Kenny Peng , Rajiv Movva , Jon Kleinberg , Emma Pierson , Nikhil Garg

Vision-language models encode images and text in a joint space, minimizing the distance between corresponding image and text pairs. How are language and images organized in this joint space, and how do the models encode meaning and…

Computer Vision and Pattern Recognition · Computer Science 2025-08-25 Isabel Papadimitriou , Huangyuan Su , Thomas Fel , Sham Kakade , Stephanie Gil

Missing input sequences are common in medical imaging data, posing a challenge for deep learning models reliant on complete input data. In this work, inspired by MultiMAE [2], we develop a masked autoencoder (MAE) paradigm for multi-modal,…

Computer Vision and Pattern Recognition · Computer Science 2026-02-04 Ayhan Can Erdur , Christian Beischl , Daniel Scholz , Jiazhen Pan , Benedikt Wiestler , Daniel Rueckert , Jan C Peeken

Sparse autoencoders (SAEs) have emerged as a promising approach for learning interpretable features from neural network activations. However, the optimization landscape for SAE training can be challenging due to correlations in the input…

Machine Learning · Computer Science 2025-11-19 Ashwin Saraswatula , David Klindt

RFdiffusion is a popular and well-established model for generation of protein structures. However, this generative process offers limited insight into its internal representations and how they contribute to the final protein structure.…

Quantitative Methods · Quantitative Biology 2025-12-01 Wojciech Zarzecki , Paulina Szymczak , Ewa Szczurek , Kamil Deja

Interpretability is essential in medical imaging to ensure that clinicians can comprehend and trust artificial intelligence models. In this paper, we propose a novel interpretable approach that combines attribute regularization of the…

Image and Video Processing · Electrical Eng. & Systems 2023-12-15 Maxime Di Folco , Cosmin I. Bercea , Julia A. Schnabel

Recently, automated medical image segmentation methods based on deep learning have achieved great success. However, they heavily rely on large annotated datasets, which are costly and time-consuming to acquire. Few-shot learning aims to…

Artificial Intelligence · Computer Science 2024-08-20 Jiayu Huo , Ruiqiang Xiao , Haotian Zheng , Yang Liu , Sebastien Ourselin , Rachel Sparks

A common goal of mechanistic interpretability is to decompose the activations of neural networks into features: interpretable properties of the input computed by the model. Sparse autoencoders (SAEs) are a popular method for finding these…

Machine Learning · Computer Science 2025-02-10 Patrick Leask , Bart Bussmann , Michael Pearce , Joseph Bloom , Curt Tigges , Noura Al Moubayed , Lee Sharkey , Neel Nanda

Sparse Autoencoders (SAEs) have emerged as a powerful unsupervised method for extracting sparse representations from language models, yet scalable training remains a significant challenge. We introduce a suite of 256 SAEs, trained on each…

Vision-language models and their adaptations to image segmentation tasks present enormous potential for producing highly accurate and interpretable results. However, implementations based on CLIP and BiomedCLIP are still lagging behind more…

Image and Video Processing · Electrical Eng. & Systems 2025-09-08 Julia Dietlmeier , Oluwabukola Grace Adegboro , Vayangi Ganepola , Claudia Mazo , Noel E. O'Connor

Masked Autoencoder (MAE) has recently been shown to be effective in pre-training Vision Transformers (ViT) for natural image analysis. By reconstructing full images from partially masked inputs, a ViT encoder aggregates contextual…

Image and Video Processing · Electrical Eng. & Systems 2023-04-24 Lei Zhou , Huidong Liu , Joseph Bae , Junjun He , Dimitris Samaras , Prateek Prasanna

Sparse autoencoders (SAEs) are increasingly used for safety-relevant applications including alignment detection and model steering. These use cases require SAE latents to be as atomic as possible. Each latent should represent a single…

Machine Learning · Computer Science 2026-04-07 Matthew Levinson