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The task of Multiple Sequence Alignment (MSA) is a constrained combinatorial optimization problem that is generally considered a complex computational problem. In this paper, we first present a binary encoding of MSA and devise a…

Portfolio optimization under strict cardinality constraints is a combinatorial challenge that defies classical convex optimization techniques, particularly in the context of "Direct Indexing" and ESG-constrained mandates. In the Noisy…

Quantum Physics · Physics 2026-02-17 Javier Mancilla , Theodoros D. Bouloumis , Frederic Goguikian

The quantum approximate optimization algorithm (QAOA) is one of the most prominent proposed applications for near-term quantum computing. Here we study the ability of QAOA to solve hard constraint satisfaction problems, as opposed to…

Quantum Physics · Physics 2022-08-16 Sami Boulebnane , Ashley Montanaro

Large language models (LLMs) have revolutionized natural language processing by solving a wide range of tasks simply guided by a prompt. Yet their performance is highly sensitive to prompt formulation. While automatic prompt optimization…

Computation and Language · Computer Science 2025-06-18 Tom Zehle , Moritz Schlager , Timo Heiß , Matthias Feurer

Quantum annealing offers a promising paradigm for solving NP-hard combinatorial optimization problems, but its practical application is severely hindered by two challenges: the complex, manual process of translating problem descriptions…

Machine Learning · Computer Science 2025-09-03 Huixiang Zhang , Mahzabeen Emu , Salimur Choudhury

In this paper, we propose CUDA-L2, a system that combines large language models (LLMs) and reinforcement learning (RL) to automatically optimize Half-precision General Matrix Multiply (HGEMM) CUDA kernels. Using CUDA execution speed as the…

Machine Learning · Computer Science 2025-12-15 Songqiao Su , Xiaofei Sun , Xiaoya Li , Albert Wang , Jiwei Li , Chris Shum

Quantum computing has the potential to speed up some optimization methods. One can use quantum computers to solve linear systems via Quantum Linear System Algorithms (QLSAs). QLSAs can be used as a subroutine for algorithms that require…

Optimization and Control · Mathematics 2024-12-23 Zeguan Wu , Pouya Sampourmahani , Mohammadhossein Mohammadisiahroudi , Tamás Terlaky

Quantum annealing is a heuristic optimization algorithm that exploits quantum evolution to approximately find lowest energy states. Quantum annealers have scaled up in recent years to tackle increasingly larger and more highly connected…

Quantum Physics · Physics 2025-07-04 Humberto Munoz Bauza , Daniel A. Lidar

The demand for classical-quantum hybrid algorithms to solve large-scale combinatorial optimization problems using quantum annealing (QA) has increased. One approach involves obtaining an approximate solution using classical algorithms and…

Quantum Physics · Physics 2024-11-12 Taisei Takabayashi , Masayuki Ohzeki

We show through numerical simulation that the Quantum Approximate Optimization Algorithm (QAOA) for higher-order, random-coefficient, heavy-hex compatible spin glass Ising models has strong parameter concentration across problem sizes from…

Quantum Physics · Physics 2024-11-13 Elijah Pelofske , Andreas Bärtschi , Lukasz Cincio , John Golden , Stephan Eidenbenz

Quantum Approximate Optimization Algorithms (QAOA) promise efficient solutions to classically intractable combinatorial optimization problems by harnessing shallow-depth quantum circuits. Yet, their performance and scalability often hinge…

Quantum Physics · Physics 2025-05-02 Kuan-Cheng Chen , Hiromichi Matsuyama , Wei-Hao Huang

Hybrid Quantum Classical (HQC) algorithms constitute one of the most effective paradigms for exploiting the computational advantages of quantum systems in large-scale numerical tasks. By operating in high-dimensional Hilbert spaces, quantum…

Quantum Physics · Physics 2025-11-12 Amin Ebrahimi , Farzan Haddadi

We present a novel framework for automated interior design that combines large language models (LLMs) with grid-based integer programming to jointly optimize room layout and furniture placement. Given a textual prompt, the LLM-driven agent…

Computer Vision and Pattern Recognition · Computer Science 2026-03-09 Chucheng Xiang , Ruchao Bao , Biyin Feng , Wenzheng Wu , Zhongyuan Liu , Yirui Guan , Ligang Liu

The section-carry based carry lookahead adder (SCBCLA) topology was proposed as an improved high-speed alternative to the conventional carry lookahead adder (CCLA) topology in previous works. Self-timed and FPGA-based implementations of…

Hardware Architecture · Computer Science 2016-03-28 P Balasubramanian , N E Mastorakis

Chain-of-Thought (CoT) reasoning significantly elevates the complex problem-solving capabilities of multimodal large language models (MLLMs). However, adapting CoT to vision typically discretizes signals to fit LLM inputs, causing early…

Computer Vision and Pattern Recognition · Computer Science 2026-04-23 Tao Cheng , Shi-Zhe Chen , Hao Zhang , Yixin Qin , Jinwen Luo , Zheng Wei

In this work, we introduce a novel Quadratic Binary Optimization (QBO) framework for training a quantized neural network. The framework enables the use of arbitrary activation and loss functions through spline interpolation, while Forward…

Machine Learning · Computer Science 2025-12-09 Wenxin Li , Chuan Wang , Hongdong Zhu , Qi Gao , Yin Ma , Hai Wei , Kai Wen

Modern software systems complexity challenges efficient testing, as traditional machine learning (ML) struggles with large test suites. This research presents a hybrid framework integrating Quantum Annealing with ML to optimize test case…

Software Engineering · Computer Science 2025-06-04 Gopichand Bandarupalli

This paper proposes a novel combination of constraint encoding methods for the Quantum Approximate Optimization Ansatz (QAOA). Real-world optimization problems typically consist of multiple types of constraints. To solve these optimization…

The section-carry based carry lookahead adder (SCBCLA) architecture was proposed as an efficient alternative to the conventional carry lookahead adder (CCLA) architecture for the physical implementation of computer arithmetic. In previous…

Hardware Architecture · Computer Science 2017-11-09 P Balasubramanian

Combinatorial optimization is a promising area for achieving quantum speedup. Quantum approximate optimization algorithm (QAOA) is designed to search for low-energy states of the Ising model, which correspond to near-optimal solutions of…

Quantum Physics · Physics 2025-10-14 Tatsuhiko Shirai , Nozomu Togawa