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Sparse Mixtures of Experts (SMoE) scales model capacity without significant increases in training and inference costs, but exhibits the following two issues: (1) Low expert activation, where only a small subset of experts are activated for…

Computation and Language · Computer Science 2024-04-24 Xun Wu , Shaohan Huang , Wenhui Wang , Furu Wei

Survival analysis is a fundamental tool for modeling time-to-event outcomes in healthcare. Recent advances have introduced flexible neural network approaches for improved predictive performance. However, most of these models do not provide…

Machine Learning · Statistics 2025-09-10 Mert Ketenci , Vincent Jeanselme , Harry Reyes Nieva , Shalmali Joshi , Noémie Elhadad

Mixture-of-experts (MoE) is becoming popular due to its success in improving the model quality, especially in Transformers. By routing tokens with a sparse gate to a few experts (i.e., a small pieces of the full model), MoE can easily…

Machine Learning · Computer Science 2022-10-11 Xiaonan Nie , Xupeng Miao , Shijie Cao , Lingxiao Ma , Qibin Liu , Jilong Xue , Youshan Miao , Yi Liu , Zhi Yang , Bin Cui

The development of molecular signatures for the prediction of time-to-event outcomes is a methodologically challenging task in bioinformatics and biostatistics. Although there are numerous approaches for the derivation of marker…

Applications · Statistics 2014-01-09 Andreas Mayr , Matthias Schmid

Breast ultrasound imaging is an important noninvasive method for early breast cancer diagnosis, but automatic benign/malignant classification remains challenging due to tumor heterogeneity, blurred boundaries, and data imbalance. To improve…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Xinyang Zhai , Chong Yang , Ruizhi Zhang

Accurate and transparent prediction of cancer survival times on the level of individual patients can inform and improve patient care and treatment practices. In this paper, we design a model that concurrently learns to accurately predict…

Machine Learning · Computer Science 2018-01-31 Maruan Al-Shedivat , Avinava Dubey , Eric P. Xing

We study the problem of inferring heterogeneous treatment effects from time-to-event data. While both the related problems of (i) estimating treatment effects for binary or continuous outcomes and (ii) predicting survival outcomes have been…

Machine Learning · Computer Science 2022-01-25 Alicia Curth , Changhee Lee , Mihaela van der Schaar

Large language models are typically deployed as monolithic systems, requiring the full model even when applications need only a narrow subset of capabilities, e.g., code, math, or domain-specific knowledge. Mixture-of-Experts (MoEs)…

Computation and Language · Computer Science 2026-05-12 Ryan Wang , Akshita Bhagia , Sewon Min

Dynamical systems in the life sciences are often composed of complex mixtures of overlapping behavioral regimes. Cellular subpopulations may shift from cycling to equilibrium dynamics or branch towards different developmental fates. The…

Machine Learning · Computer Science 2025-10-13 Nathan Quiblier , Roy Friedman , Matthew Ricci

In recent years, Mixture-of-Experts (MoE) has emerged as an effective approach for enhancing the capacity of deep neural network (DNN) with sub-linear computational costs. However, storing all experts on GPUs incurs significant memory…

Machine Learning · Computer Science 2025-03-11 Suraiya Tairin , Shohaib Mahmud , Haiying Shen , Anand Iyer

This paper presents a comprehensive review of the Mixture-of-Experts (MoE) architecture in large language models, highlighting its ability to significantly enhance model performance while maintaining minimal computational overhead. Through…

Machine Learning · Computer Science 2025-12-24 Danyang Zhang , Junhao Song , Ziqian Bi , Xinyuan Song , Yingfang Yuan , Tianyang Wang , Joe Yeong , Junfeng Hao

Spatio-temporal forecasting is crucial in transportation, logistics, and supply chain management. However, current methods struggle with large, complex datasets. We propose a dynamic, multi-modal approach that integrates the strengths of…

Machine Learning · Computer Science 2024-08-27 Sagar Srinivas Sakhinana , Geethan Sannidhi , Chidaksh Ravuru , Venkataramana Runkana

Mixture-of-Experts (MoE) decouples model capacity from per-token computation, yet their scalability remains limited by the physical dimensions of depth and width. To overcome this, we propose Mixture of Universal Experts (MOUE),a MoE…

Machine Learning · Computer Science 2026-03-06 Yilong Chen , Naibin Gu , Junyuan Shang , Zhenyu Zhang , Yuchen Feng , Jiawei Sheng , Tingwen Liu , Shuohuan Wang , Yu Sun , Hua Wu , Haifeng Wang

Mixture-of-Experts (MoE) has emerged as a promising paradigm for efficiently scaling large language models without a proportional increase in computational cost. However, the standard training strategy of Top-K router prevents MoE models…

Computation and Language · Computer Science 2025-10-01 Yaoxiang Wang , Qingguo Hu , Yucheng Ding , Ruizhe Wang , Yeyun Gong , Jian Jiao , Yelong Shen , Peng Cheng , Jinsong Su

When drawing causal inferences about the effects of multiple treatments on clustered survival outcomes using observational data, we need to address implications of the multilevel data structure, multiple treatments, censoring and unmeasured…

Methodology · Statistics 2022-02-18 Liangyuan Hu , Jiayi Ji , Ronald D. Ennis , Joseph W. Hogan

Prognostic models in survival analysis are aimed at understanding the relationship between patients' covariates and the distribution of survival time. Traditionally, semi-parametric models, such as the Cox model, have been assumed. These…

Machine Learning · Statistics 2020-11-06 Denise Rava , Jelena Bradic

Modern health data science applications leverage abundant molecular and electronic health data, providing opportunities for machine learning to build statistical models to support clinical practice. Time-to-event analysis, also called…

Recent studies show that using diffusion models for time series signal reconstruction holds great promise. However, such approaches remain largely unexplored in the domain of medical time series. The unique characteristics of the…

Machine Learning · Computer Science 2026-01-13 Ci Zhang , Huayu Li , Changdi Yang , Jiangnan Xia , Yanzhi Wang , Xiaolong Ma , Jin Lu , Ao Li , Geng Yuan

Survival analysis stands as a pivotal process in cancer treatment research, crucial for predicting patient survival rates accurately. Recent advancements in data collection techniques have paved the way for enhancing survival predictions by…

Machine Learning · Computer Science 2024-07-26 Linhao Qu , Dan Huang , Shaoting Zhang , Xiaosong Wang

Benefiting from the advancements in deep learning, various genomic analytical techniques, such as survival analysis, classification of tumors and their subtypes, and exploration of specific pathways, have significantly enhanced our…

Machine Learning · Computer Science 2023-12-19 Xiangyu Meng , Xue Li , Qing Yang , Huanhuan Dai , Lian Qiao , Hongzhen Ding , Long Hao , Xun Wang