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Ensuring alignment, which refers to making models behave in accordance with human intentions [1,2], has become a critical task before deploying large language models (LLMs) in real-world applications. For instance, OpenAI devoted six months…

Artificial Intelligence · Computer Science 2024-03-22 Yang Liu , Yuanshun Yao , Jean-Francois Ton , Xiaoying Zhang , Ruocheng Guo , Hao Cheng , Yegor Klochkov , Muhammad Faaiz Taufiq , Hang Li

The application of large language models (LLMs) in healthcare holds significant promise for enhancing clinical decision-making, medical research, and patient care. However, their integration into real-world clinical settings raises critical…

Computers and Society · Computer Science 2025-09-18 Manar Aljohani , Jun Hou , Sindhura Kommu , Xuan Wang

While Large Language Models (LLMs) demonstrate significant potential in providing accessible mental health support, their practical deployment raises critical trustworthiness concerns due to the domains high-stakes and safety-sensitive…

Computation and Language · Computer Science 2026-03-04 Zixin Xiong , Ziteng Wang , Haotian Fan , Xinjie Zhang , Wenxuan Wang

The rapid progress in Large Language Models (LLMs) could transform many fields, but their fast development creates significant challenges for oversight, ethical creation, and building user trust. This comprehensive review looks at key trust…

Computers and Society · Computer Science 2024-07-22 Md Meftahul Ferdaus , Mahdi Abdelguerfi , Elias Ioup , Kendall N. Niles , Ken Pathak , Steven Sloan

Large Language Models (LLMs) such as ChatGPT, have gained significant attention due to their impressive natural language processing capabilities. It is crucial to prioritize human-centered principles when utilizing these models.…

Computation and Language · Computer Science 2023-06-21 Yue Huang , Qihui Zhang , Philip S. Y , Lichao Sun

Large language models (LLMs) have demonstrated remarkable capabilities across a range of natural language processing (NLP) tasks, capturing the attention of both practitioners and the broader public. A key question that now preoccupies the…

Computation and Language · Computer Science 2025-06-04 Yahan Li , Yi Wang , Yi Chang , Yuan Wu

Despite the superior capabilities of Multimodal Large Language Models (MLLMs) across diverse tasks, they still face significant trustworthiness challenges. Yet, current literature on the assessment of trustworthy MLLMs remains limited,…

Computation and Language · Computer Science 2024-12-09 Yichi Zhang , Yao Huang , Yitong Sun , Chang Liu , Zhe Zhao , Zhengwei Fang , Yifan Wang , Huanran Chen , Xiao Yang , Xingxing Wei , Hang Su , Yinpeng Dong , Jun Zhu

The widespread adoption of web applications has made their security a critical concern and has increased the need for systematic ways to assess whether they can be considered trustworthy. However, "trust" assessment remains an open problem…

Cryptography and Security · Computer Science 2026-03-26 Oleksandr Yarotskyi , José D'Abruzzo Pereira , João R. Campos

The swift progress and widespread acceptance of artificial intelligence (AI) systems highlight a pressing requirement to comprehend both the capabilities and potential risks associated with AI. Given the linguistic complexity, cultural…

Computation and Language · Computer Science 2024-11-06 Emad A. Alghamdi , Reem I. Masoud , Deema Alnuhait , Afnan Y. Alomairi , Ahmed Ashraf , Mohamed Zaytoon

Large language models (LLMs), such as ChatGPT, have rapidly penetrated into people's work and daily lives over the past few years, due to their extraordinary conversational skills and intelligence. ChatGPT has become the fastest-growing…

Computation and Language · Computer Science 2024-09-04 Wenxuan Wang

Large language models (LLMs) have a transformative impact on a variety of scientific tasks across disciplines including biology, chemistry, medicine, and physics. However, ensuring the safety alignment of these models in scientific research…

The remarkable capabilities of Large Language Models (LLMs) make them increasingly compelling for adoption in real-world healthcare applications. However, the risks associated with using LLMs in medical applications have not been…

Recently, there has been growing interest in using Large Language Models (LLMs) for scientific research. Numerous benchmarks have been proposed to evaluate the ability of LLMs for scientific research. However, current benchmarks are mostly…

Computation and Language · Computer Science 2024-11-08 Liangtai Sun , Yang Han , Zihan Zhao , Da Ma , Zhennan Shen , Baocai Chen , Lu Chen , Kai Yu

The rapid development and widespread adoption of Audio Large Language Models (ALLMs) demand rigorous evaluation of their trustworthiness. However, existing evaluation frameworks are primarily designed for text and fail to capture…

Large Language Models (LLM) have taken the front seat in most of the news since November 2022, when ChatGPT was introduced. After more than one year, one of the major reasons companies are resistant to adopting them is the limited…

Artificial Intelligence · Computer Science 2024-03-13 Carlo Lipizzi

The rapid proliferation of Large Language Models (LLMs) has raised significant trustworthiness and ethical concerns. Despite the widespread adoption of LLMs across domains, there is still no clear consensus on how to define and…

Computation and Language · Computer Science 2025-05-06 José Siqueira de Cerqueira , Kai-Kristian Kemell , Rebekah Rousi , Nannan Xi , Juho Hamari , Pekka Abrahamsson

As Large Language Models (LLMs) continue to revolutionize Natural Language Processing (NLP) applications, critical concerns about their trustworthiness persist, particularly in safety and robustness. To address these challenges, we…

Software Engineering · Computer Science 2025-10-16 Ruoyu Sun , Da Song , Jiayang Song , Yuheng Huang , Lei Ma

The success of large language models (LLMs) in scientific domains has heightened safety concerns, prompting numerous benchmarks to evaluate their scientific safety. Existing benchmarks often suffer from limited risk coverage and a reliance…

In recent years, the rapid advancement of Artificial Intelligence (AI) technologies, particularly Large Language Models (LLMs), has revolutionized the paradigm of scientific discovery, establishing AI-for-Science (AI4Science) as a dynamic…

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