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Numerous benchmarks aim to evaluate the capabilities of Large Language Models (LLMs) for causal inference and reasoning. However, many of them can likely be solved through the retrieval of domain knowledge, questioning whether they achieve…

Machine Learning · Computer Science 2024-07-12 Linying Yang , Vik Shirvaikar , Oscar Clivio , Fabian Falck

Entity Resolution (ER) is the problem of semi-automatically determining when two entities refer to the same underlying entity, with applications ranging from healthcare to e-commerce. Traditional ER solutions required considerable manual…

Artificial Intelligence · Computer Science 2024-04-09 Navapat Nananukul , Khanin Sisaengsuwanchai , Mayank Kejriwal

This study investigates whether large language models (LLMs) mirror human neurocognition during abstract reasoning. We compared the performance and neural representations of human participants with those of eight open-source LLMs on an…

Neurons and Cognition · Quantitative Biology 2025-08-15 Christopher Pinier , Sonia Acuña Vargas , Mariia Steeghs-Turchina , Dora Matzke , Claire E. Stevenson , Michael D. Nunez

Phenotype-driven gene prioritization is a critical process in the diagnosis of rare genetic disorders for identifying and ranking potential disease-causing genes based on observed physical traits or phenotypes. While traditional approaches…

Quantitative Methods · Quantitative Biology 2024-04-04 Junyoung Kim , Jingye Yang , Kai Wang , Chunhua Weng , Cong Liu

This research paper investigates the application of Large Language Models (LLMs) in healthcare, specifically focusing on enhancing medical decision support through Retrieval-Augmented Generation (RAG) integrated with hospital-specific data…

Computation and Language · Computer Science 2025-05-07 Mohammad Shoaib Ansari , Mohd Sohail Ali Khan , Shubham Revankar , Aditya Varma , Anil S. Mokhade

Prevalent solution for BioNER involves using representation learning techniques coupled with sequence labeling. However, such methods are inherently task-specific, demonstrate poor generalizability, and often require dedicated model for…

Computation and Language · Computer Science 2024-04-30 Junyi Biana , Weiqi Zhai , Xiaodi Huang , Jiaxuan Zheng , Shanfeng Zhu

Large language models (LLM) have demonstrated remarkable capabilities in various biomedical natural language processing (NLP) tasks, leveraging the demonstration within the input context to adapt to new tasks. However, LLM is sensitive to…

Computation and Language · Computer Science 2025-11-17 Mingchen Li , Zaifu Zhan , Han Yang , Yongkang Xiao , Jiatan Huang , Rui Zhang

Language representation models such as BERT could effectively capture contextual semantic information from plain text, and have been proved to achieve promising results in lots of downstream NLP tasks with appropriate fine-tuning. However,…

Computation and Language · Computer Science 2020-10-07 Deming Ye , Yankai Lin , Jiaju Du , Zhenghao Liu , Peng Li , Maosong Sun , Zhiyuan Liu

Large Language Models (LLMs) and LLM-based agents show great promise in accelerating scientific research. Existing benchmarks for measuring this potential and guiding future development continue to evolve from pure recall and rote knowledge…

This paper reports on the use of prompt engineering and GPT-3.5 for biomedical query-focused multi-document summarisation. Using GPT-3.5 and appropriate prompts, our system achieves top ROUGE-F1 results in the task of obtaining…

Computation and Language · Computer Science 2023-11-10 Diego Mollá

Systematic reviews are comprehensive literature reviews that address highly focused research questions and represent the highest form of evidence in medicine. A critical step in this process is the development of complex Boolean queries to…

Information Retrieval · Computer Science 2025-06-03 Shuai Wang , Harrisen Scells , Bevan Koopman , Guido Zuccon

Large language models (LLMs) have achieved strong performance on medical exam-style tasks, motivating growing interest in their deployment in real-world clinical settings. However, clinical decision-making is inherently safety-critical,…

Computation and Language · Computer Science 2026-04-13 Xiaohan Ren , Chenxiao Fan , Wenyin Ma , Hongliang He , Chongming Gao , Xiaoyan Zhao , Fuli Feng

Large language models (LLMs) such as ChatGPT have gained considerable interest across diverse research communities. Their notable ability for text completion and generation has inaugurated a novel paradigm for language-interfaced problem…

Quantitative Methods · Quantitative Biology 2024-02-22 Hengchuang Yin , Zhonghui Gu , Fanhao Wang , Yiparemu Abuduhaibaier , Yanqiao Zhu , Xinming Tu , Xian-Sheng Hua , Xiao Luo , Yizhou Sun

Large Language Models (LLMs) excel in data synthesis but can be inaccurate in domain-specific tasks, which retrieval-augmented generation (RAG) systems address by leveraging user-provided data. However, RAGs require optimization in both…

Computation and Language · Computer Science 2024-11-05 Kazi Ahmed Asif Fuad , Lizhong Chen

Large Language Models (LLMs) have revolutionized both general natural language processing and domain-specific applications such as code synthesis, legal reasoning, and finance. However, while prior studies have explored individual model…

Software Engineering · Computer Science 2025-12-05 Gunjan Das , Paheli Bhattacharya , Rishabh Gupta

Pretrained language models (PLMs) have motivated research on what kinds of knowledge these models learn. Fill-in-the-blanks problem (e.g., cloze tests) is a natural approach for gauging such knowledge. BioLAMA generates prompts for…

Computation and Language · Computer Science 2023-01-26 Zonghai Yao , Yi Cao , Zhichao Yang , Hong Yu

The increasing complexity of clinical decision-making, alongside the rapid expansion of electronic health records (EHR), presents both opportunities and challenges for delivering data-informed care. This paper proposes a clinical decision…

Artificial Intelligence · Computer Science 2025-10-03 Leon Garza , Anantaa Kotal , Michael A. Grasso , Emre Umucu

Background: Biomedical entity normalization is critical to biomedical research because the richness of free-text clinical data, such as progress notes, can often be fully leveraged only after translating words and phrases into structured…

Computation and Language · Computer Science 2024-05-27 Nicholas J Dobbins

Engineering LLMs to accelerate life sciences research requires a robust alignment with biomedical knowledge. We observe that biomedical text exhibits a fundamentally different uncertainty structure from general text: dense low-confidence…

Radiology reports are critical for clinical decision-making but often lack a standardized format, limiting both human interpretability and machine learning (ML) applications. While large language models (LLMs) have shown strong capabilities…

Computation and Language · Computer Science 2025-07-15 Johannes Moll , Louisa Fay , Asfandyar Azhar , Sophie Ostmeier , Tim Lueth , Sergios Gatidis , Curtis Langlotz , Jean-Benoit Delbrouck