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Large language models (LLMs) have made significant progress in various domains, including healthcare. However, the specialized nature of clinical language understanding tasks presents unique challenges and limitations that warrant further…

Computation and Language · Computer Science 2023-08-01 Yuqing Wang , Yun Zhao , Linda Petzold

The vast amount of biomedical information available today presents a significant challenge for investigators seeking to digest, process, and understand these findings effectively. Large Language Models (LLMs) have emerged as powerful tools…

Computation and Language · Computer Science 2024-07-19 Alexander R. Pelletier , Joseph Ramirez , Irsyad Adam , Simha Sankar , Yu Yan , Ding Wang , Dylan Steinecke , Wei Wang , Peipei Ping

Large language models (LLMs) are increasingly expected to function as collaborative partners, engaging in back-and-forth dialogue to solve complex, ambiguous problems. However, current LLMs often falter in real-world settings, defaulting to…

Artificial Intelligence · Computer Science 2025-07-30 Tenghao Huang , Sihao Chen , Muhao Chen , Jonathan May , Longqi Yang , Mengting Wan , Pei Zhou

Background: Clinical trials rely on transparent inclusion criteria to ensure generalizability. In contrast, benchmarks validating health-related large language models (LLMs) rarely characterize the "patient" or "query" populations they…

Artificial Intelligence · Computer Science 2026-04-17 Alvin Rajkomar , Pavan Sudarshan , Angela Lai , Lily Peng

In recent years, Large Language Models (LLMs) have become widely used in medical applications, such as clinical decision support, medical education, and medical question answering. Yet, these models are often English-centric, limiting their…

Computation and Language · Computer Science 2026-02-06 Chaimae Abouzahir , Congbo Ma , Nizar Habash , Farah E. Shamout

Large Language Models (LLMs) have recently demonstrated remarkable performance in general tasks across various fields. However, their effectiveness within specific domains such as drug development remains challenges. To solve these…

Artificial Intelligence · Computer Science 2024-10-16 Tengfei Ma , Xuan Lin , Tianle Li , Chaoyi Li , Long Chen , Peng Zhou , Xibao Cai , Xinyu Yang , Daojian Zeng , Dongsheng Cao , Xiangxiang Zeng

The adoption of large language models (LLMs) to assist clinicians has attracted remarkable attention. Existing works mainly adopt the close-ended question-answering (QA) task with answer options for evaluation. However, many clinical…

This study presents a systematic approach to identifying and characterizing student misconceptions in online learning environments through a novel combination of quantitative performance analysis and large language model (LLM) assessment.…

Computation and Language · Computer Science 2026-05-04 Michael J. Parker , Maria G. Zavala-Cerna

Large language models (LLMs) have excelled across domains, also delivering notable performance on the medical evaluation benchmarks, such as MedQA. However, there still exists a significant gap between the reported performance and the…

Computation and Language · Computer Science 2024-06-06 Yuxuan Zhou , Xien Liu , Chen Ning , Ji Wu

We present Clinical Camel, an open large language model (LLM) explicitly tailored for clinical research. Fine-tuned from LLaMA-2 using QLoRA, Clinical Camel achieves state-of-the-art performance across medical benchmarks among openly…

Computation and Language · Computer Science 2023-08-21 Augustin Toma , Patrick R. Lawler , Jimmy Ba , Rahul G. Krishnan , Barry B. Rubin , Bo Wang

Large Language Models (LLMs) are often criticized for lacking true "understanding" and the ability to "reason" with their knowledge, being seen merely as autocomplete systems. We believe that this assessment might be missing a nuanced…

Artificial Intelligence · Computer Science 2024-06-18 Venkat Venkatasubramanian

Healthcare systems around the world are grappling with issues like inefficient diagnostics, rising costs, and limited access to specialists. These problems often lead to delays in treatment and poor health outcomes. Most current AI and deep…

Artificial Intelligence · Computer Science 2025-12-22 Maliha Tabassum , M Shamim Kaiser

Large Language Models (LLMs) demonstrate an impressive capacity to recall a vast range of factual knowledge. However, understanding their underlying reasoning and internal mechanisms in exploiting this knowledge remains a key research area.…

Computation and Language · Computer Science 2024-08-07 Marco Bronzini , Carlo Nicolini , Bruno Lepri , Jacopo Staiano , Andrea Passerini

This article explores the gaps that can manifest when using a large language model (LLM) to obtain simplified interpretations of data practices from a complex privacy policy. We exemplify these gaps to showcase issues in accuracy,…

Computation and Language · Computer Science 2025-09-03 Rinku Dewri

Scientific reasoning, the process through which humans apply logic, evidence, and critical thinking to explore and interpret scientific phenomena, is essential in advancing knowledge reasoning across diverse fields. However, despite…

Computation and Language · Computer Science 2026-04-21 Yibo Yan , Shen Wang , Jiahao Huo , Jingheng Ye , Zhendong Chu , Xuming Hu , Philip S. Yu , Carla Gomes , Bart Selman , Qingsong Wen

Large Language Models (LLM) benchmarks tell us when models fail, but not why they fail. A wrong answer on a reasoning dataset may stem from formatting issues, calculation errors, or dataset noise rather than weak reasoning. Without…

Artificial Intelligence · Computer Science 2026-02-18 Shir Ashury-Tahan , Yifan Mai , Elron Bandel , Michal Shmueli-Scheuer , Leshem Choshen

We analyze knowledge-based visual question answering, for which given a question, the models need to ground it into the visual modality and retrieve the relevant knowledge from a given large knowledge base (KB) to be able to answer. Our…

Artificial Intelligence · Computer Science 2024-04-17 Elham J. Barezi , Parisa Kordjamshidi

Large language models (LLMs) have achieved remarkable performance in natural language understanding and generation tasks. However, they often suffer from limitations such as difficulty in incorporating new knowledge, generating…

Artificial Intelligence · Computer Science 2024-03-05 Yilin Wen , Zifeng Wang , Jimeng Sun

Artificial Intelligence (AI) is rapidly embedded in critical decision-making systems, however their foundational ``black-box'' models require eXplainable AI (XAI) solutions to enhance transparency, which are mostly oriented to experts,…

Machine Learning · Computer Science 2025-06-17 Eva Paraschou , Ioannis Arapakis , Sofia Yfantidou , Sebastian Macaluso , Athena Vakali

Large language models (LLMs), such as ChatGPT, have received substantial attention due to their capabilities for understanding and generating human language. While there has been a burgeoning trend in research focusing on the employment of…