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Purpose: Microscopic fractional anisotropy ({\mu}FA) can disentangle microstructural information from orientation dispersion. While double diffusion encoding (DDE) MRI methods are widely used to extract accurate {\mu}FA, it has only…

Medical Physics · Physics 2019-03-21 Rafael Neto Henriques , Sune N Jespersen , Noam Shemesh

Positron Emission Tomography and Magnetic Resonance Imaging (PET-MRI) systems can obtain functional and anatomical scans. PET suffers from a low signal-to-noise ratio. Meanwhile, the k-space data acquisition process in MRI is…

Image and Video Processing · Electrical Eng. & Systems 2024-07-12 Taofeng Xie , Zhuo-Xu Cui , Chen Luo , Huayu Wang , Congcong Liu , Yuanzhi Zhang , Xuemei Wang , Yanjie Zhu , Guoqing Chen , Dong Liang , Qiyu Jin , Yihang Zhou , Haifeng Wang

Whether it be in a man-made machine or a biological system, form and function are often directly related. In the latter, however, this particular relationship is often unclear due to the intricate nature of biology. Here we developed a…

Neurons and Cognition · Quantitative Biology 2020-05-27 Fernanda L. Ribeiro , Steffen Bollmann , Alexander M. Puckett

Background: Being born very or extreme preterm is a major source of cerebral anomalies and neurodevelopmental disorders, whose occurrence depends on many perinatal factors. A better understanding of these factors could be provided by…

Magnetic resonance imaging (MRI) is a cornerstone of clinical neuroimaging, yet conventional MRIs provide qualitative information heavily dependent on scanner hardware and acquisition settings. While quantitative MRI (qMRI) offers intrinsic…

Knowledge of the noise distribution in magnitude diffusion MRI images is the centerpiece to quantify uncertainties arising from the acquisition process. The use of parallel imaging methods, the number of receiver coils and imaging filters…

Computer Vision and Pattern Recognition · Computer Science 2018-10-03 Samuel St-Jean , Alberto De Luca , Max A. Viergever , Alexander Leemans

The purpose of this study is to present and compare three denoising diffusion probabilistic models (DDPMs) that generate 3D $T_1$-weighted MRI human brain images. Three DDPMs were trained using 80,675 image volumes from 42,406 subjects…

Image and Video Processing · Electrical Eng. & Systems 2025-11-03 Samuel W. Remedios , Aaron Carass , Jerry L. Prince , Blake E. Dewey

Deep learning has emerged as a promising approach for learning the nonlinear mapping between diffusion-weighted MR images and tissue parameters, which enables automatic and deep understanding of the brain microstructures. However, the…

Computer Vision and Pattern Recognition · Computer Science 2025-05-21 Wenxin Fan , Jian Cheng , Qiyuan Tian , Ruoyou Wu , Juan Zou , Zan Chen , Shanshan Wang

Diffusion magnetic resonance imaging datasets suffer from low Signal-to-Noise Ratio, especially at high b-values. Acquiring data at high b-values contains relevant information and is now of great interest for microstructural and…

Computer Vision and Pattern Recognition · Computer Science 2016-06-27 Samuel St-Jean , Pierrick Coupé , Maxime Descoteaux

Deep learning algorithms for predicting neuroimaging data have shown considerable promise in various applications. Prior work has demonstrated that deep learning models that take advantage of the data's 3D structure can outperform standard…

Image and Video Processing · Electrical Eng. & Systems 2023-03-07 Yuda Bi , Anees Abrol , Zening Fu , Jiayu Chen , Jingyu Liu , Vince Calhoun

The biological brain has inspired multiple advances in machine learning. However, most state-of-the-art models in computer vision do not operate like the human brain, simply because they are not capable of changing or improving their…

Computer Vision and Pattern Recognition · Computer Science 2024-12-23 David Calhas , João Marques , Arlindo L. Oliveira

We study the theoretical behavior of denoising score matching--the learning task associated to diffusion models--when the data distribution is supported on a low-dimensional manifold and the score is parameterized using a random feature…

Machine Learning · Computer Science 2026-04-14 Anand Jerry George , Nicolas Macris

Diffusion MRI (dMRI) provides contrast that reflect diffusing spins' interactions with microstructural features of biological systems, but its specificity remains limited due to the ambiguity of its relation to the underlying…

Medical Physics · Physics 2022-03-29 Jonas L. Olesen , Leif Østergaard , Noam Shemesh , Sune N. Jespersen

The wide variety of brain imaging technologies allows us to exploit information inherent to different data modalities. The richness of multimodal datasets may increase predictive power and reveal latent variables that otherwise would have…

Computer Vision and Pattern Recognition · Computer Science 2018-04-13 Alvaro Ulloa , Sergey Plis , Vince Calhoun

We propose ReMiDi, a novel method for inferring neuronal microstructure as arbitrary 3D meshes using a differentiable diffusion Magnetic Resonance Imaging (dMRI) simulator. We first implemented in PyTorch a differentiable dMRI simulator…

Image and Video Processing · Electrical Eng. & Systems 2025-03-03 Prathamesh Pradeep Khole , Zahra Kais Petiwala , Shri Prathaa Magesh , Ehsan Mirafzali , Utkarsh Gupta , Jing-Rebecca Li , Andrada Ianus , Razvan Marinescu

Brains construct not only "first-order" representations of the environment but also "higher-order" representations about those representations -- including higher-order uncertainty estimates that guide learning and adaptive behavior.…

Machine Learning · Computer Science 2026-04-15 Hojjat Azimi Asrari , Megan A. K. Peters

Tissue microstructure has significance as a biomarker, however its accurate inference with diffusion magnetic resonance (MR) is still an open problem. With few exceptions, diffusion weighted (DW) MR models either process diffusion MR data…

Medical Physics · Physics 2019-08-20 Alpay Özcan

In cryo-electron microscopy, the 3D electric potentials of an ensemble of molecules are projected along arbitrary viewing directions to yield noisy 2D images. The volume maps representing these potentials typically exhibit a great deal of…

Applications · Statistics 2018-02-08 Joakim Andén , Amit Singer

Functional variability in both gray matter (GM) and white matter (WM) is closely associated with human brain cognitive and developmental processes, and is commonly assessed using functional connectivity (FC). However, as a correlation-based…

Neurons and Cognition · Quantitative Biology 2025-10-09 Xinle Chang , Yang Yang , Yueran Li , Zhengcen Li , Haijin Zeng , Jingyong Su

Studying learning-related plasticity is central to understanding the acquisition of complex skills, for example learning to master a musical instrument. Over the past three decades, conventional group-based functional magnetic resonance…

Neurons and Cognition · Quantitative Biology 2026-04-09 Simon Leipold , Ryssa Moffat
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