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A central goal of neuroscience is to understand how activity in the nervous system is related to features of the external world, or to features of the nervous system itself. A common approach is to model neural responses as a weighted…

Machine Learning · Statistics 2015-05-14 Kristofer E. Bouchard

Background and objective Risk prediction models aim at identifying people at higher risk of developing a target disease. Feature selection is particularly important to improve the prediction model performance avoiding overfitting and to…

Machine Learning · Computer Science 2024-02-09 N. Cueto-López , M. T. García-Ordás , V. Dávila-Batista , V. Moreno , N. Aragonés , R. Alaiz-Rodríguez

Genome-wide association studies (GWAS) have achieved great success in the genetic study of Alzheimer's disease (AD). Collaborative imaging genetics studies across different research institutions show the effectiveness of detecting genetic…

Machine Learning · Computer Science 2017-04-28 Qingyang Li , Dajiang Zhu , Jie Zhang , Derrek Paul Hibar , Neda Jahanshad , Yalin Wang , Jieping Ye , Paul M. Thompson , Jie Wang

This paper proposes a novel method for model selection in linear regression by utilizing the solution path of $\ell_1$ regularized least-squares (LS) approach (i.e., Lasso). This method applies the complex-valued least angle regression and…

Methodology · Statistics 2018-06-20 Muhammad Naveed Tabassum , Esa Ollila

Large language models (LLMs) are increasingly deployed in real-world systems, yet they can produce toxic or biased outputs that undermine safety and trust. Post-hoc model repair provides a practical remedy, but the high cost of parameter…

Machine Learning · Computer Science 2025-10-24 Xuran Li , Jingyi Wang

Modern variable selection procedures make use of penalization methods to execute simultaneous model selection and estimation. A popular method is the LASSO (least absolute shrinkage and selection operator), the use of which requires…

Methodology · Statistics 2023-01-12 Meadhbh O'Neill , Kevin Burke

Feature selection is an important data preprocessing in data mining and machine learning which can be used to reduce the feature dimension without deteriorating model's performance. Since obtaining annotated data is laborious or even…

Machine Learning · Computer Science 2022-04-08 Zhenzhen Sun , Yuanlong Yu

In statistics and machine learning, logistic regression is a widely-used supervised learning technique primarily employed for binary classification tasks. When the number of observations greatly exceeds the number of predictor variables, we…

Machine Learning · Statistics 2024-04-02 Agniva Chowdhury , Pradeep Ramuhalli

The goal of regression and classification methods in supervised learning is to minimize the empirical risk, that is, the expectation of some loss function quantifying the prediction error under the empirical distribution. When facing scarce…

Optimization and Control · Mathematics 2019-07-15 Soroosh Shafieezadeh-Abadeh , Daniel Kuhn , Peyman Mohajerin Esfahani

Consider the problem of estimating average treatment effects when a large number of covariates are used to adjust for possible confounding through outcome regression and propensity score models. The conventional approach of model building…

Statistics Theory · Mathematics 2018-01-31 Zhiqiang Tan

Brain disorders are an umbrella term for a group of neurological and psychiatric conditions that have a major effect on thinking, feeling, and acting. These conditions encompass a wide range of conditions. The illnesses in question pose…

Neurons and Cognition · Quantitative Biology 2025-11-11 Aniruddha Saha , Soujanya Hazra , Sanjay Ghosh

Predicting future interactions or novel links in networks is an indispensable tool across diverse domains, including genetic research, online social networks, and recommendation systems. Among the numerous techniques developed for link…

Social and Information Networks · Computer Science 2025-03-24 Maja Lindström , Christopher Blöcker , Tommy Löfstedt , Martin Rosvall

High resolution microarrays and second-generation sequencing platforms are powerful tools to investigate genome-wide alterations in DNA copy number, methylation and gene expression associated with a disease. An integrated genomic profiling…

Applications · Statistics 2013-04-22 Ronglai Shen , Sijian Wang , Qianxing Mo

Gallstone disease is a complex, multifactorial condition with significant global health burdens. Identifying underlying risk factors and their interactions is crucial for early diagnosis, targeted prevention, and effective clinical…

Applications · Statistics 2025-06-18 Chitradipa Chakraborty , Nayana Mukherjee

Neuroimage analysis usually involves learning thousands or even millions of variables using only a limited number of samples. In this regard, sparse models, e.g. the lasso, are applied to select the optimal features and achieve high…

Machine Learning · Computer Science 2015-03-26 Bo Xin , Lingjing Hu , Yizhou Wang , Wen Gao

In this work a method to regularize Cox frailty models is proposed that accommodates time-varying covariates and time-varying coefficients and is based on the full instead of the partial likelihood. A particular advantage in this framework…

Methodology · Statistics 2020-04-01 Maike Hohberg , Andreas Groll

Shrinkage estimators that possess the ability to produce sparse solutions have become increasingly important to the analysis of today's complex datasets. Examples include the LASSO, the Elastic-Net and their adaptive counterparts.…

Methodology · Statistics 2017-02-09 Hongmei Liu , J. Sunil Rao

Many applied settings in empirical economics involve simultaneous estimation of a large number of parameters. In particular, applied economists are often interested in estimating the effects of many-valued treatments (like teacher effects…

Machine Learning · Statistics 2017-04-03 Alberto Abadie , Maximilian Kasy

In observational studies, researchers must select a method to control for confounding. Options include propensity score methods and regression. It remains unclear how dataset characteristics (size, overlap in propensity scores, exposure…

Methodology · Statistics 2022-10-21 J. Wilkinson , M. A. Mamas , E. Kontopantelis

Data irregularity in cancer genomics studies has been widely observed in the form of outliers and heavy-tailed distributions in the complex traits. In the past decade, robust variable selection methods have emerged as powerful alternatives…

Methodology · Statistics 2024-05-14 Yuwen Liu , Jie Ren , Shuangge Ma , Cen Wu