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Pathology plays an important role in disease diagnosis, treatment decision-making and drug development. Previous works on interpretability for machine learning models on pathology images have revolved around methods such as attention value…

The rapid advancements in transformer-based language models have revolutionized natural language processing, yet understanding the internal mechanisms of these models remains a significant challenge. This paper explores the application of…

Machine Learning · Computer Science 2025-02-14 Edith Natalia Villegas Garcia , Alessio Ansuini

Protein language models have revolutionized structure prediction, but their nonlinear nature obscures how sequence representations inform structure prediction. While sparse autoencoders (SAEs) offer a path to interpretability here by…

Biomolecules · Quantitative Biology 2025-03-13 Nithin Parsan , David J. Yang , John J. Yang

RFdiffusion is a popular and well-established model for generation of protein structures. However, this generative process offers limited insight into its internal representations and how they contribute to the final protein structure.…

Quantitative Methods · Quantitative Biology 2025-12-01 Wojciech Zarzecki , Paulina Szymczak , Ewa Szczurek , Kamil Deja

As large language models (LLMs) grow in scale and capability, understanding their internal mechanisms becomes increasingly critical. Sparse autoencoders (SAEs) have emerged as a key tool in mechanistic interpretability, enabling the…

Computation and Language · Computer Science 2025-06-10 Jiaming Li , Haoran Ye , Yukun Chen , Xinyue Li , Lei Zhang , Hamid Alinejad-Rokny , Jimmy Chih-Hsien Peng , Min Yang

Sparse autoencoders (SAEs) have recently emerged as a powerful tool for interpreting the features learned by large language models (LLMs). By reconstructing features with sparsely activated networks, SAEs aim to recover complex superposed…

Machine Learning · Computer Science 2026-03-05 Jingyi Cui , Qi Zhang , Yifei Wang , Yisen Wang

Determining company similarity is a vital task in finance, underpinning risk management, hedging, and portfolio diversification. Practitioners often rely on sector and industry classifications such as SIC and GICS codes to gauge similarity,…

Recent research suggests that the feed-forward module within Transformers can be viewed as a collection of key-value memories, where the keys learn to capture specific patterns from the input based on the training examples. The values then…

Computation and Language · Computer Science 2023-10-25 Sunit Bhattacharya , Ondrej Bojar

Deep learning, particularly with the advancement of Large Language Models, has transformed biomolecular modeling, with protein language models such as ESM inspiring emerging RNA language models such as RiNALMo. Recent work has begun…

Biomolecules · Quantitative Biology 2026-05-18 Taehan Kim , Sangdae Nam

A recent line of work has shown promise in using sparse autoencoders (SAEs) to uncover interpretable features in neural network representations. However, the simple linear-nonlinear encoding mechanism in SAEs limits their ability to perform…

Machine Learning · Computer Science 2025-01-31 Charles O'Neill , Alim Gumran , David Klindt

Sparse autoencoders (SAEs) have proven useful in disentangling the opaque activations of neural networks, primarily large language models, into sets of interpretable features. However, adapting them to domains beyond language, such as…

Machine Learning · Computer Science 2025-11-13 Ege Erdogan , Ana Lucic

With the integration of image modality, the semantic space of multimodal large language models (MLLMs) is more complex than text-only models, making their interpretability more challenging and their alignment less stable, particularly…

Machine Learning · Computer Science 2025-06-18 Hantao Lou , Changye Li , Jiaming Ji , Yaodong Yang

Sparse autoencoders (SAEs) extract millions of interpretable features from a language model, but flat feature inventories aren't very useful on their own. Domain concepts get mixed with generic and weakly grounded features, while related…

Artificial Intelligence · Computer Science 2026-04-29 John Winnicki , Abeynaya Gnanasekaran , Eric Darve

Sparse autoencoders (SAEs) have emerged as a powerful tool for uncovering interpretable features in large language models (LLMs) through the sparse directions they learn. However, the sheer number of extracted directions makes comprehensive…

Computation and Language · Computer Science 2025-11-11 Xinyuan Yan , Shusen Liu , Kowshik Thopalli , Bei Wang

Sparse autoencoders (SAEs) decompose large language model (LLM) activations into latent features that reveal mechanistic structure. Conventional SAEs train on broad data distributions, forcing a fixed latent budget to capture only…

Machine Learning · Computer Science 2025-08-14 Charles O'Neill , Mudith Jayasekara , Max Kirkby

Recent work by Anthropic on Mechanistic interpretability claims to understand and control Large Language Models by extracting human-interpretable features from their neural activation patterns using sparse autoencoders (SAEs). If…

Machine Learning · Computer Science 2026-01-07 Raphael Ronge , Markus Maier , Frederick Eberhardt

Understanding the internal machinations of deep Transformer-based NLP models is more crucial than ever as these models see widespread use in various domains that affect the public at large, such as industry, academia, finance, health. While…

Computation and Language · Computer Science 2026-05-13 Dan Pluth , Zachary Nicholas Houghton , Yu Zhou , Vijay K. Gurbani

Large language models (LLMs) have been widely deployed across numerous fields. Reinforcement Learning from Human Feedback (RLHF) leverages reward models (RMs) as proxies for human preferences to align LLM behaviors with human values, making…

Machine Learning · Computer Science 2025-11-26 Shuyi Zhang , Wei Shi , Sihang Li , Jiayi Liao , Hengxing Cai , Xiang Wang

Sparse autoencoders (SAEs) \citep{bricken2023monosemanticity,gao2024scalingevaluatingsparseautoencoders} rely on dictionary learning to extract interpretable features from neural networks at scale in an unsupervised manner, with…

Machine Learning · Computer Science 2025-05-02 Hans Peter , Anders Søgaard

A central goal for mechanistic interpretability has been to identify the right units of analysis in large language models (LLMs) that causally explain their outputs. While early work focused on individual neurons, evidence that neurons…

Computation and Language · Computer Science 2026-05-05 Or Shafran , Atticus Geiger , Mor Geva