Related papers: RiboPO: Preference Optimization for Structure- and…

Direct Preference Optimization (DPO) has emerged as a more computationally efficient alternative to Reinforcement Learning from Human Feedback (RLHF) with Proximal Policy Optimization (PPO), eliminating the need for reward models and online…

Reinforcement Learning from Human Feedback (RLHF) has become central to aligning large language models with human values, typically by first learning a reward model from preference data which is then used to update the model with…

Reinforcement Learning from Human Feedback (RLHF) has become central to aligning large language models with human values, typically by first learning a reward model from preference data which is then used to update the model with…

Structure-based drug design (SBDD) aims to efficiently discover high-affinity ligands within vast chemical spaces. However, current generative models struggle with objective misalignment and rigid sampling budgets. We present MolFORM, a…

Efficiently aligning large-scale video diffusion models with human intent requires a scalable and trajectory-aware pathway that bridges the inherent discrepancy between training noise distributions and practical inference trajectories.…

Text-to-image diffusion models deliver high-quality images, yet aligning them with human preferences remains challenging. We revisit diffusion-based Direct Preference Optimization (DPO) for these models and identify a critical pathology:…

Direct Preference Optimisation (DPO) has emerged as a powerful method for aligning Large Language Models (LLMs) with human preferences, offering a stable and efficient alternative to approaches that use Reinforcement learning via Human…

Iterative data generation and model retraining are widely used to align large language models (LLMs). It typically involves a policy model to generate on-policy responses and a reward model to guide training data selection. Direct…

This paper studies the alignment process of generative models with Reinforcement Learning from Human Feedback (RLHF). We first identify the primary challenges of existing popular methods like offline PPO and offline DPO as lacking in…

Reinforcement Learning with Verifiable Rewards (RLVR) demonstrates significant potential in enhancing the reasoning capabilities of Large Language Models (LLMs). However, existing RLVR methods are often constrained by issues such as…

Preference optimization methods typically begin training with a well-trained SFT model as a reference model. In RLHF and DPO, a regularization term is used during the preference optimization process to prevent the policy model from…

Without using explicit reward, direct preference optimization (DPO) employs paired human preference data to fine-tune generative models, a method that has garnered considerable attention in large language models (LLMs). However, exploration…

Lead optimization in drug discovery requires efficiently navigating vast chemical space through iterative cycles to enhance molecular properties while preserving structural similarity to the original lead compound. Despite recent advances,…

Direct Preference Optimization (DPO) has emerged as a de-facto approach for aligning language models with human preferences. Recent work has shown DPO's effectiveness relies on training data quality. In particular, clear quality differences…

We present a multi-objective binder design paradigm based on instruction fine-tuning and direct preference optimization (DPO) of autoregressive protein language models (pLMs). Multiple design objectives are encoded in the language model…

The task adaptation and alignment of Large Multimodal Models (LMMs) have been significantly advanced by instruction tuning and further strengthened by recent preference optimization. Yet, most LMMs still suffer from severe modality…

Aligning large language models (LLMs) with human preferences has gained significant attention, with Proximal Policy Optimization (PPO) as a standard yet computationally expensive method and Direct Preference Optimization (DPO) as a more…

Direct Preference Optimization (DPO) and its variants have become standard for aligning Large Language Models due to their simplicity and offline stability. However, we identify two fundamental limitations. First, the optimal policy depends…

In recent years, text-to-speech (TTS) has seen impressive advancements through large-scale language models, achieving human-level speech quality. Integrating human feedback has proven effective for enhancing robustness in these systems.…

Software engineering presents complex, multi-step challenges for Large Language Models (LLMs), requiring reasoning over large codebases and coordinated tool use. The difficulty of these tasks is exemplified by benchmarks like SWE-bench,…