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Deep reinforcement learning (DRL) has long been a promising solution for sequential resource management in wireless networks. However, conventional DRL methods are fundamentally limited by their reliance on unimodal policy distributions,…

Developing new drugs is laborious and costly, demanding extensive time investment. In this paper, we introduce a de-novo drug design strategy, which harnesses the capabilities of language models to devise targeted drugs for specific…

Biomolecules · Quantitative Biology 2025-05-20 Salma J. Ahmed , Emad A. Mohammed

Diffusion Models (DMs), as a leading class of generative models, offer key advantages for reinforcement learning (RL), including multi-modal expressiveness, stable training, and trajectory-level planning. This survey delivers a…

Machine Learning · Computer Science 2025-10-15 Changfu Xu , Jianxiong Guo , Yuzhu Liang , Haiyang Huang , Haodong Zou , Xi Zheng , Shui Yu , Xiaowen Chu , Jiannong Cao , Tian Wang

Reinforcement learning (RL) has emerged as a powerful tool for aligning diffusion models with human preferences, typically by optimizing a single reward function under a KL regularization constraint. In practice, however, human preferences…

Machine Learning · Computer Science 2026-04-17 Qi Zhang , Dawei Wang , Shaofeng Zou

Diffusion models have achieved remarkable success in text-to-image generation. However, their practical applications are hindered by the misalignment between generated images and corresponding text prompts. To tackle this issue,…

Computer Vision and Pattern Recognition · Computer Science 2025-03-28 Zijing Hu , Fengda Zhang , Long Chen , Kun Kuang , Jiahui Li , Kaifeng Gao , Jun Xiao , Xin Wang , Wenwu Zhu

A major obstacle to the realization of novel inorganic materials with desirable properties is the inability to perform efficient optimization across both materials properties and synthesis of those materials. In this work, we propose a…

Materials Science · Physics 2022-10-24 Elton Pan , Christopher Karpovich , Elsa Olivetti

Real-time multi-view 3D reconstruction is a mission-critical application for key edge-native use cases, such as fire rescue, where timely and accurate 3D scene modeling enables situational awareness and informed decision-making. However,…

Machine Learning · Computer Science 2025-10-13 Motahare Mounesan , Sourya Saha , Houchao Gan , Md. Nurul Absur , Saptarshi Debroy

Discovering functional crystalline materials entails navigating an immense combinatorial design space. While recent advances in generative artificial intelligence have enabled the sampling of chemically plausible compositions and…

Machine Learning · Computer Science 2025-11-11 Hyunsoo Park , Aron Walsh

Distribution Matching Distillation (DMD) facilitates efficient inference by distilling multi-step diffusion models into few-step variants. Concurrently, Reinforcement Learning (RL) has emerged as a vital tool for aligning generative models…

Computer Vision and Pattern Recognition · Computer Science 2026-03-26 Dengyang Jiang , Dongyang Liu , Zanyi Wang , Qilong Wu , Liuzhuozheng Li , Hengzhuang Li , Xin Jin , David Liu , Changsheng Lu , Zhen Li , Bo Zhang , Mengmeng Wang , Steven Hoi , Peng Gao , Harry Yang

We address the problem of fine-tuning diffusion models for reward-guided generation in biomolecular design. While diffusion models have proven highly effective in modeling complex, high-dimensional data distributions, real-world…

Diffusion models are powerful generative models that allow for precise control over the characteristics of the generated samples. While these diffusion models trained on large datasets have achieved success, there is often a need to…

RNA inverse folding, designing sequences to form specific 3D structures, is critical for therapeutics, gene regulation, and synthetic biology. Current methods, focused on sequence recovery, struggle to address structural objectives like…

Machine Learning · Computer Science 2026-01-28 Qi Si , Xuyang Liu , Penglei Wang , Xin Guo , Yuan Qi , Yuan Cheng

Diffusion models surpass previous generative models in sample quality and training stability. Recent works have shown the advantages of diffusion models in improving reinforcement learning (RL) solutions. This survey aims to provide an…

Machine Learning · Computer Science 2024-02-26 Zhengbang Zhu , Hanye Zhao , Haoran He , Yichao Zhong , Shenyu Zhang , Haoquan Guo , Tingting Chen , Weinan Zhang

Denoising-based generative models, particularly diffusion and flow matching algorithms, have achieved remarkable success. However, aligning their output distributions with complex downstream objectives, such as human preferences,…

Machine Learning · Computer Science 2025-08-29 Luozhijie Jin , Zijie Qiu , Jie Liu , Zijie Diao , Lifeng Qiao , Ning Ding , Alex Lamb , Xipeng Qiu

Reinforcement learning (RL) has been effective for post-training autoregressive (AR) language models, but extending these methods to diffusion language models (DLMs) is challenging due to intractable sequence-level likelihoods. Existing…

Autonomous Underwater Vehicles (AUVs) are essential for marine exploration, yet their control remains highly challenging due to nonlinear dynamics and uncertain environmental disturbances. This paper presents a diffusion-augmented…

Robotics · Computer Science 2025-10-01 Jingzehua Xu , Guanwen Xie , Weiyi Liu , Jiwei Tang , Ziteng Yang , Tianxiang Xing , Yiyuan Yang , Shuai Zhang , Xiaofan Li

Model-based Deep Reinforcement Learning (RL) assumes the availability of a model of an environment's underlying transition dynamics. This model can be used to predict future effects of an agent's possible actions. When no such model is…

Machine Learning · Computer Science 2021-12-15 Andreas Sedlmeier , Michael Kölle , Robert Müller , Leo Baudrexel , Claudia Linnhoff-Popien

Reinforcement Learning (RL) has recently received significant attention from the process systems engineering and control communities. Recent works have investigated the application of RL to identify optimal scheduling decision in the…

Systems and Control · Electrical Eng. & Systems 2022-03-11 Max Mowbray , Dongda Zhang , Ehecatl Antonio Del Rio Chanona

Goal-directed molecular generation requires satisfying heterogeneous constraints such as protein--ligand compatibility and multi-objective drug-like properties, yet existing methods often optimize these constraints in isolation, failing to…

Machine Learning · Computer Science 2026-04-14 Yanting Li , Zhuoyang Jiang , Enyan Dai , Lei Wang , Wen-Cai Ye , Li Liu

Diffusion generative models have emerged as a powerful framework for addressing problems in structural biology and structure-based drug design. These models operate directly on 3D molecular structures. Due to the unfavorable scaling of…

Biomolecules · Quantitative Biology 2024-05-10 Ian Dunn , David Ryan Koes