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Various adaptive randomization procedures (adaptive designs) have been proposed to clinical trials. This paper discusses several broad families of procedures, such as the play-the-winner rule and Markov chain model, randomized…

Statistics Theory · Mathematics 2009-08-30 Li-Xin Zhang

One approach to understand people's efforts to reduce disease transmission, is to consider the effect of behaviour on case rates. In this paper we present a spatial infection-reducing game model of public behaviour, formally equivalent to a…

Physics and Society · Physics 2022-01-05 James Burridge , Michal Gnacik

Human behaviour strongly influences the spread of infectious diseases: understanding the interplay between epidemic dynamics and adaptive behaviours is essential to improve response strategies to epidemics, with the goal of containing the…

Physics and Society · Physics 2024-08-21 Marco Mancastroppa , Alessandro Vezzani , Vittoria Colizza , Raffaella Burioni

We consider a stochastic Susceptible-Exposed-Infected-Recovered (SEIR) epidemiological model. Through the use of a normal form coordinate transform, we are able to analytically derive the stochastic center manifold along with the…

Adaptation and Self-Organizing Systems · Physics 2015-05-13 Eric Forgoston , Lora Billings , Ira B. Schwartz

The duration, type and structure of connections between individuals in real-world populations play a crucial role in how diseases invade and spread. Here, we incorporate the aforementioned heterogeneities into a model by considering a…

Physics and Society · Physics 2018-04-05 Rosanna C Barnard , Istvan Z Kiss , Luc Berthouze , Joel C Miller

The spread of an infectious disease is known to change people's behavior, which in turn affects the spread of disease. Adaptive network models that account for both epidemic and behavior change have found oscillations, but in an extremely…

Quantitative Methods · Quantitative Biology 2018-04-16 N. Sherborne , K. B. Blyuss , I. Z. Kiss

Strategic test allocation plays a major role in the control of both emerging and existing pandemics (e.g., COVID-19, HIV). Widespread testing supports effective epidemic control by (1) reducing transmission via identifying cases, and (2)…

Methodology · Statistics 2022-12-06 Ivana Malenica , Jeremy R. Coyle , Mark J. van der Laan , Maya L. Petersen

In this study, we present an integro-differential model to simulate the local spread of infections. The model incorporates a standard susceptible-infected-recovered (\textit{SIR}-) model enhanced by an integral kernel, allowing for…

Dynamical Systems · Mathematics 2023-07-20 Moritz Schäfer , Karol Niedzielewski , Thomas Götz , Tyll Krüger

Adaptive response to a varying environment is a common feature of biological organisms. Reproducing such features in electronic systems and circuits is of great importance for a variety of applications. Here, we consider memory models…

Cell Behavior · Quantitative Biology 2013-10-29 Fabio Lorenzo Traversa , Yuriy V. Pershin , Massimiliano Di Ventra

Here we propose and implement a generalized mathematical model to find the time evolution of population in infectious diseases and apply the model to study the recent COVID-19 pandemic. Our model at the core is a non-local generalization of…

Populations and Evolution · Quantitative Biology 2020-05-01 Saumyak Mukherjee , Sayantan Mondal , Biman Bagchi

We propose a generative model and an inference scheme for epidemic processes on dynamic, adaptive contact networks. Network evolution is formulated as a link-Markovian process, which is then coupled to an individual-level stochastic SIR…

Methodology · Statistics 2020-04-07 Fan Bu , Allison E. Aiello , Jason Xu , Alexander Volfovsky

Contacts' temporal ordering and dynamics are crucial for understanding the transmission of infectious diseases. We introduce an interaction-driven model of an airborne disease over contact networks. We demonstrate our interaction-driven…

Social and Information Networks · Computer Science 2022-08-11 Alex Abbey , Yanir Marmor , Yuval Shahar , Osnat Mokryn

Effective modeling of human interactions is of utmost importance when forecasting behaviors such as future trajectories. Each individual, with its motion, influences surrounding agents since everyone obeys to social non-written rules such…

Computer Vision and Pattern Recognition · Computer Science 2024-02-20 Francesco Marchetti , Federico Becattini , Lorenzo Seidenari , Alberto Del Bimbo

Adaptive experiments improve efficiency by adjusting treatment assignments based on past outcomes, but this adaptivity breaks the i.i.d.\ assumptions that underpin classical asymptotics. At the same time, many questions of interest are…

Machine Learning · Statistics 2026-05-05 Houssam Zenati , Bariscan Bozkurt , Arthur Gretton

The brain rapidly adapts to new contexts and learns from limited data, a coveted characteristic that artificial intelligence (AI) algorithms struggle to mimic. Inspired by the mechanical oscillatory rhythms of neural cells, we developed a…

Machine Learning · Computer Science 2026-03-17 Hoony Kang , Wolfgang Losert

Causal effect estimation in networked systems is central to data-driven decision making. In such settings, interventions on one unit can spill over to others, and in complex physical or social systems, the interaction pathways driving these…

Machine Learning · Statistics 2025-11-27 Sadegh Shirani , Mohsen Bayati

The time-dependent transmission coefficient for the Kramers problem exhibits different behaviors in different parameter regimes. In the high friction regime it decays monotonically ("non-adiabatic"), and in the low friction regime it decays…

Statistical Mechanics · Physics 2009-10-31 Ramon Reigada , Aldo H. Romero , Katja Lindenberg , Jose M. Sancho

We study the stochastic susceptible-infected-recovered (SIR) model with time-dependent forcing using analytic techniques which allow us to disentangle the interaction of stochasticity and external forcing. The model is formulated as a…

Populations and Evolution · Quantitative Biology 2010-11-23 Andrew J Black , Alan J McKane

Personalized predictive medicine necessitates the modeling of patient illness and care processes, which inherently have long-term temporal dependencies. Healthcare observations, recorded in electronic medical records, are episodic and…

Machine Learning · Statistics 2017-04-12 Trang Pham , Truyen Tran , Dinh Phung , Svetha Venkatesh

We study the dynamics of a spatially structured model of worldwide epidemics and formulate predictions for arrival times of the disease at any city in the network. The model is comprised of a system of ordinary differential equations…

Pattern Formation and Solitons · Physics 2018-02-14 Lawrence M. Chen , Matt Holzer , Anne Shapiro