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Estimating the counterfactual outcome of treatment is essential for decision-making in public health and clinical science, among others. Often, treatments are administered in a sequential, time-varying manner, leading to an exponentially…

Machine Learning · Statistics 2024-07-16 Shenghao Wu , Wenbin Zhou , Minshuo Chen , Shixiang Zhu

Machine learning models are widely used in real-world applications. However, their complexity makes it often challenging to interpret the rationale behind their decisions. Counterfactual explanations (CEs) have emerged as a viable solution…

Machine Learning · Computer Science 2024-03-04 Muhammad Suffian , Jose M. Alonso-Moral , Alessandro Bogliolo

Machine learning models perform well on several healthcare tasks and can help reduce the burden on the healthcare system. However, the lack of explainability is a major roadblock to their adoption in hospitals. \textit{How can the decision…

Machine Learning · Computer Science 2023-06-13 Supriya Nagesh , Nina Mishra , Yonatan Naamad , James M. Rehg , Mehul A. Shah , Alexei Wagner

The heart's electrical activity, recorded through Electrocardiography (ECG), is essential for diagnosing various cardiovascular conditions. However, many existing ECG segmentation models rely on complex, multi-layered architectures such as…

Machine Learning · Computer Science 2025-08-25 Muhammad Fathur Rohman Sidiq , Abdurrouf , Didik Rahadi Santoso

Most of state of the art methods applied on time series consist of deep learning methods that are too complex to be interpreted. This lack of interpretability is a major drawback, as several applications in the real world are critical…

Machine Learning · Computer Science 2021-04-05 Thomas Rojat , Raphaël Puget , David Filliat , Javier Del Ser , Rodolphe Gelin , Natalia Díaz-Rodríguez

Counterfactual explanations suggest what should be different in the input instance to change the outcome of an AI system. When dealing with counterfactual explanations in the field of Predictive Process Monitoring, however, control flow…

Artificial Intelligence · Computer Science 2025-08-26 Andrei Buliga , Chiara Di Francescomarino , Chiara Ghidini , Ivan Donadello , Fabrizio Maria Maggi

Counterfactual explanations have emerged as a popular solution for the eXplainable AI (XAI) problem of elucidating the predictions of black-box deep-learning systems due to their psychological validity, flexibility across problem domains…

Machine Learning · Computer Science 2022-12-20 Eoin Delaney , Arjun Pakrashi , Derek Greene , Mark T. Keane

Explainable AI (XAI) is an increasingly important area of machine learning research, which aims to make black-box models transparent and interpretable. In this paper, we propose a novel approach to XAI that uses the so-called counterfactual…

Artificial Intelligence · Computer Science 2023-08-02 Bastian Pfeifer , Mateusz Krzyzinski , Hubert Baniecki , Anna Saranti , Andreas Holzinger , Przemyslaw Biecek

Machine and deep learning survival models demonstrate similar or even improved time-to-event prediction capabilities compared to classical statistical learning methods yet are too complex to be interpreted by humans. Several model-agnostic…

Machine Learning · Computer Science 2023-04-17 Mateusz Krzyziński , Mikołaj Spytek , Hubert Baniecki , Przemysław Biecek

Explainable Artificial Intelligence (XAI) is essential for the transparency and clinical adoption of Clinical Decision Support Systems (CDSS). However, the real-world effectiveness of existing XAI methods remains limited and is…

Machine Learning · Computer Science 2026-01-26 Alessandro Gambetti , Qiwei Han , Hong Shen , Claudia Soares

The imminent need to interpret the output of a Machine Learning model with counterfactual (CF) explanations - via small perturbations to the input - has been notable in the research community. Although the variety of CF examples is…

Machine Learning · Computer Science 2024-04-23 Kleopatra Markou , Dimitrios Tomaras , Vana Kalogeraki , Dimitrios Gunopulos

The ability to accurately perform counterfactual inference on time series is crucial for decision-making in fields like finance, healthcare, and marketing, as it allows us to understand the impact of events or treatments on outcomes over…

Machine Learning · Computer Science 2026-02-18 Tomàs Garriga , Gerard Sanz , Eduard Serrahima de Cambra , Axel Brando

Counterfactual explanations are increasingly used as an Explainable Artificial Intelligence (XAI) technique to provide stakeholders of complex machine learning algorithms with explanations for data-driven decisions. The popularity of…

Artificial Intelligence · Computer Science 2023-04-26 Dieter Brughmans , Lissa Melis , David Martens

Discovering shapelets -- i.e., discriminative temporal patterns within time series -- has been widely studied to address the inherent complexity of time-series classification (TSC) and to make model decision-making processes more…

Machine Learning · Computer Science 2026-05-20 Seongjun Lee , Seokhyun Lee , Changhee Lee

Counterfactual explanations (CEs) provide recourse recommendations for individuals affected by algorithmic decisions. A key challenge is generating CEs that are robust against various perturbation types (e.g. input and model perturbations)…

Machine Learning · Computer Science 2026-03-02 Junqi Jiang , Francesco Leofante , Antonio Rago , Francesca Toni

Counterfactual inference enables clinicians to ask "what if" questions about patient outcomes, but standard methods assume feature independence and simultaneous modifiability -- assumptions violated by longitudinal clinical data. We…

Machine Learning · Computer Science 2026-02-25 Jingya Cheng , Alaleh Azhir , Jiazi Tian , Hossein Estiri

Medical time series data, such as EEG and ECG, are vital for diagnosing neurological and cardiovascular diseases. However, their precise interpretation faces significant challenges due to high annotation costs, leading to data scarcity, and…

Machine Learning · Computer Science 2026-01-13 Kaito Tanaka , Aya Nakayama , Masato Ito , Yuji Nishimura , Keisuke Matsuda

With the wide use of deep neural networks (DNN), model interpretability has become a critical concern, since explainable decisions are preferred in high-stake scenarios. Current interpretation techniques mainly focus on the feature…

Machine Learning · Computer Science 2021-01-19 Fan Yang , Ninghao Liu , Mengnan Du , Xia Hu

Counterfactual Explanations (CEs) are an important tool in Algorithmic Recourse for addressing two questions: 1. What are the crucial factors that led to an automated prediction/decision? 2. How can these factors be changed to achieve a…

Machine Learning · Computer Science 2023-11-23 Xuan Zhao , Klaus Broelemann , Gjergji Kasneci

Large language models (LLMs) enable waveform-to-text ECG interpretation and interactive clinical questioning, yet most ECG-LLM systems still rely on weak signal-text alignment and retrieval without explicit physiological or causal…

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