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Large Language Models (LLMs) have demonstrated unprecedented generative capabilities, yet their alignment with human values remains critical for ensuring helpful and harmless deployments. While Reinforcement Learning from Human Feedback…

Recent alignment methods based on Direct Preference Optimization (DPO) reformulate preference learning as supervised optimization over pairwise comparisons, offering improved efficiency and stability over reinforcement learning from human…

Machine Learning · Computer Science 2026-01-22 Yuhui Sun , Xiyao Wang , Zixi Li , YiTian Ding , Tianyang Ling , Jialuo Chen , Tianyi Yu , Zhenlong Yuan , Jinman Zhao

Direct Preference Optimization (DPO) has emerged as a simple and effective approach for aligning large language models (LLMs) with human preferences, bypassing the need for a learned reward model. Despite its growing adoption, a fundamental…

Machine Learning · Computer Science 2025-11-10 Yu Pan , Zhongze Cai , Guanting Chen , Huaiyang Zhong , Chonghuan Wang

Direct Preference Optimization (DPO), a standard method for aligning language models with human preferences, is traditionally applied to offline preferences. Recent studies show that DPO benefits from iterative training with online…

Computation and Language · Computer Science 2024-06-18 Jie Liu , Zhanhui Zhou , Jiaheng Liu , Xingyuan Bu , Chao Yang , Han-Sen Zhong , Wanli Ouyang

Generative AI can now synthesize strikingly realistic images from text, yet output quality remains highly sensitive to how prompts are phrased. Direct Preference Optimization (DPO) offers a lightweight, off-policy alternative to RL for…

Computation and Language · Computer Science 2025-07-30 Anas Mohamed , Azal Ahmad Khan , Xinran Wang , Ahmad Faraz Khan , Shuwen Ge , Saman Bahzad Khan , Ayaan Ahmad , Ali Anwar

Efficient preference optimization algorithms such as Direct Preference Optimization (DPO) have become a popular approach in aligning large language models (LLMs) with human preferences. These algorithms implicitly treat the LLM as a reward…

Computation and Language · Computer Science 2025-07-29 Tong Liu , Xiao Yu , Wenxuan Zhou , Jindong Gu , Volker Tresp

Direct Preference Optimization (DPO) and its variants have become the de facto standards for aligning large language models (LLMs) with human preferences or specific goals. However, DPO requires high-quality preference data and suffers from…

Machine Learning · Computer Science 2024-11-12 Zhuotong Chen , Fang Liu , Jennifer Zhu , Wanyu Du , Yanjun Qi

We present a multi-objective binder design paradigm based on instruction fine-tuning and direct preference optimization (DPO) of autoregressive protein language models (pLMs). Multiple design objectives are encoded in the language model…

Biological Physics · Physics 2024-03-08 Pouria Mistani , Venkatesh Mysore

Effective training of language models (LMs) for mathematical reasoning tasks demands high-quality supervised fine-tuning data. Besides obtaining annotations from human experts, a common alternative is sampling from larger and more powerful…

Computation and Language · Computer Science 2024-07-26 Tianduo Wang , Shichen Li , Wei Lu

Direct preference optimization (DPO) is a successful fine-tuning strategy for aligning large language models with human preferences without the need to train a reward model or employ reinforcement learning. DPO, as originally formulated,…

Computation and Language · Computer Science 2024-06-07 Afra Amini , Tim Vieira , Ryan Cotterell

Direct Preference Optimization (DPO) has become a popular approach for aligning language models using pairwise preferences. However, in practical post-training pipelines, on-policy generation typically yields multiple candidate responses…

Machine Learning · Computer Science 2025-06-23 Taneesh Gupta , Rahul Madhavan , Xuchao Zhang , Nagarajan Natarajan , Chetan Bansal , Saravan Rajmohan

Direct Preference Optimization (DPO) and its variants have become increasingly popular for aligning language models with human preferences. These methods aim to teach models to better distinguish between chosen (or preferred) and rejected…

Computation and Language · Computer Science 2025-06-09 Xiliang Yang , Feng Jiang , Qianen Zhang , Lei Zhao , Xiao Li

Preference optimization has made significant progress recently, with numerous methods developed to align language models with human preferences. This paper introduces $f$-divergence Preference Optimization ($f$-PO), a novel framework that…

Computation and Language · Computer Science 2025-02-18 Jiaqi Han , Mingjian Jiang , Yuxuan Song , Stefano Ermon , Minkai Xu

Aligning the output of Large Language Models (LLMs) with human preferences (e.g., by means of reinforcement learning with human feedback, or RLHF) is essential for ensuring their effectiveness in real-world scenarios. Despite significant…

Artificial Intelligence · Computer Science 2024-10-23 Pietro Bernardelle , Gianluca Demartini

Direct Preference Optimization (DPO) is a widely used RL-free method for aligning language models from pairwise preferences, but it models preferences over full sequences even though generation is driven by per-token decisions. Existing…

Computation and Language · Computer Science 2026-05-15 Truong Nguyen , Tien-Phat Nguyen , Linh Ngo Van , Duy Minh Ho Nguyen , Khoa D. Doan , Trung Le

Despite the efficacy of Direct Preference Optimization (DPO) in aligning Large Language Models (LLMs), reward hacking remains a pivotal challenge. This issue emerges when LLMs excessively reduce the probability of rejected completions to…

Computation and Language · Computer Science 2025-08-26 Chenxu Yang , Ruipeng Jia , Mingyu Zheng , Naibin Gu , Zheng Lin , Siyuan Chen , Weichong Yin , Hua Wu , Weiping Wang

The rapid rise of large language models (LLMs) has unlocked many applications but also underscores the challenge of aligning them with diverse values and preferences. Direct Preference Optimization (DPO) is central to alignment but…

Recent advancements in Direct Preference Optimization (DPO) have significantly enhanced the alignment of Large Language Models (LLMs) with human preferences, owing to its simplicity and effectiveness. However, existing methods typically…

Computation and Language · Computer Science 2024-10-28 Shilong Li , Yancheng He , Hui Huang , Xingyuan Bu , Jiaheng Liu , Hangyu Guo , Weixun Wang , Jihao Gu , Wenbo Su , Bo Zheng

Protein sequence design methods have demonstrated strong performance in sequence generation for de novo protein design. However, as the training objective was sequence recovery, it does not guarantee designability--the likelihood that a…

Machine Learning · Computer Science 2025-06-03 Fanglei Xue , Andrew Kubaney , Zhichun Guo , Joseph K. Min , Ge Liu , Yi Yang , David Baker

Direct Preference Optimization (DPO) has emerged as an effective approach for aligning large language models (LLMs) with human preferences. However, its performance is highly dependent on the quality of the underlying human preference data.…

Machine Learning · Computer Science 2026-03-10 Zixuan Huang , Yikun Ban , Lean Fu , Xiaojie Li , Zhongxiang Dai , Jianxin Li , Deqing Wang